Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Stability of Ampicillin Sodium, Nafcillin Sodium, and Oxacillin Sodium in AutoDose Infusion System Bags

Author(s):  Zhang Yanping, Trissel Lawrence A

Issue:  May/Jun 2002 - Health, Wellness, Geriatrics
View All Articles in Issue

Page(s):  226-229

Stability of Ampicillin Sodium, Nafcillin Sodium, and Oxacillin Sodium in AutoDose Infusion System Bags Page 1
Stability of Ampicillin Sodium, Nafcillin Sodium, and Oxacillin Sodium in AutoDose Infusion System Bags Page 2
Stability of Ampicillin Sodium, Nafcillin Sodium, and Oxacillin Sodium in AutoDose Infusion System Bags Page 3
Stability of Ampicillin Sodium, Nafcillin Sodium, and Oxacillin Sodium in AutoDose Infusion System Bags Page 4

Download in electronic PDF format for $75

Abstract:  The objective of this study was to evaluate the physical and chemical stability of ampicillin sodium 1 g/100 mL, nafcillin sodium 1 g/100 mL, and oxacillin sodium 1 g/100 mL, each of which was admixed in 0.9% sodium chloride injection and packaged in an AutoDose Infusion System bag.

Triplicate test samples were prepared by reconstituting the penicillin antibiotics and bringing the required amount of each drug to a final volume of 100 mL with 0.9% sodium chloride injection. The test solutions were packaged in AutoDose bags, which are ethylene vinyl acetate plastic containers designed for use in the AutoDose Infusion System. Samples were stored protected from light and were evaluated at appropriate intervals for up to 7 days at 23°C and up to 30 days at 4°C.

Physical stability was assessed by means of a multistep evaluation procedure that included both turbidimetric and particulate measurement as well as visual inspection. Chemical stability was assessed with stability-indicating high-performance liquid chromatographic (HPLC) analytical techniques based on the determination of drug concentrations initially and at appropriate intervals over the study periods.

All the penicillin admixtures were initially clear when viewed in normal fluorescent room light. When the admixtures were viewed with a Tyndall beam, a trace haze was observed with the ampicillin sodium and nafcillin sodium mixtures but not with the oxacillin sodium mixture. Measured turbidity and particulate content were low and exhibited little change in the ampicillin sodium and oxacillin sodium samples throughout the study. The nafcillin sodium samples stored at room temperature remained clear, but a microprecipitate developed in the refrigerated samples between 14 and 21 days of storage. All samples were essentially colorless throughout the study.

HPLC analysis indicated some decomposition in the samples. Ampicillin sodium, which was the least stable, exhibited a 10% loss after 24 hours at 23°C. In the samples stored at 4°C, ampicillin losses were 6% and 11% after 3 days and 5 days, respectively. Nafcillin sodium exhibited a 10% loss after 5 days at 23°C. Less than 3% loss occurred after 14 days at 4°C, but the microprecipitation that developed resulted in the termination of that portion of the study. Oxacillin sodium was the most stable; it exhibited less than a 10% loss after 7 days at 23°C and less than a 5% loss after 30 days at 4°C.

Ampicillin sodium, nafcillin sodium, and oxacillin sodium exhibited physical and chemical stability consistent with previous studies on these drugs. The AutoDose Infusion System bags did not adversely affect the physical and chemical stability of those three penicillin antibiotics.

Related Keywords: Ampicillin sodium, stability of, in AutoDose Infusion System Bags

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Stability of Ampicillin Sodium, Nafcillin Sodium, and Oxacillin Sodium in AutoDose Infusion System Bags
Zhang Yanping
, Trissel Lawrence A
May/Jun 2002
Pg. 226-229

Stability of Gentamicin Sulfate and Tobramycin Sulfate in AutoDose Infusion System Bags
Xu Quanyun A
, Trissel Lawrence A, Saenz Christopher A, Ingram Delshalonda S
Mar/Apr 2002
Pg. 152-154

Stability of Amikacin Sulfate in AutoDose Infusion System Bags
Zhang Yanping
, Trissel Lawrence A
May/Jun 2003
Pg. 230-232

Stability of Clindamycin Phosphate in AutoDose Infusion System Bags
Xu Quanyun A
, Trissel Lawrence A
Mar/Apr 2003
Pg. 149-151

In-use Stability of Ceftaroline Fosamil in Elastomeric Home Infusion Systems and MINI-BAG Plus Containers
Bhattacharya Sisir
, Parekh Satish, Dedhiya Mahendra
Sep/Oct 2015
Pg. 432-436

Stability of Dexmedetomidine in Polyvinyl Chloride Bags Containing 0.9% Sodium Chloride Intended for Subcutaneous Infusions
Wolfe Amanda
, Zhang Jeremy, Lapenskie Julie, Downar James, Kanji Salmaan
Jul/Aug 2021
Pg. 330-335

Stability of Dexmedetomidine in 0.9% Sodium Chloride in Two Types of Intravenous Infusion Bags
Marquis Kathleen
, Hohlfelder Benjamin, Szumita Paul M
Sep/Oct 2017
Pg. 436-439

Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration
Ben Michel
, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Nov/Dec 2007
Pg. 520-524

Physiochemical Stability of Diluted Trastuzumab Infusion Solutions in Polypropylene Infusion Bags
Kaiser Jeanette
, Kramer Irene
Nov/Dec 2011
Pg. 515-520

Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags
Breukels Oscar
, van der Gronde Toon, Simons-Sanders Kathleen, Crul Mirjam
Jul/Aug 2018
Pg. 345-349

Prolonged In-use Stability of Reconstituted Herceptin in Commercial Intravenous Bags
Nalenz Heiko
, Köpf Ellen, Dietel Elke
Sep/Oct 2018
Pg. 417-423

Chemical Stability of Cefuroxime Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D
Jul/Aug 2003
Pg. 310-312

Physical and Chemical Stability of Trepostinil Sodium Injection Packaged in Plastic Syringe Pump Reservoirs.
Xu Quanyun A
, Trissel Lawrence A, Pham Lien
May/Jun 2004
Pg. 228-230

Chemical Stability of Phenylephrine HCl After Reconstitution in 0.9% Sodium Chloride Injection for Infusion
Gupta Vishnu D
Mar/Apr 2004
Pg. 153-155

Stability of Ampicillin in Normal Saline and Buffered Normal Saline
Maher Moureddine
, Jensen Kara J, Lee David, Nix David E
Jul/Aug 2016
Pg. 338-342

Physical and Chemical Stability of Urapidil in 0.9% Sodium Chloride in Elastomeric Infusion Pump
Tomasello Cristina
, Leggieri Anna, Rabbia Franco, Veglio Franco, Baietto Lorena, Fulcheri Chiara, De Nicolò Amedeo, De Perri Giovanni, D'Avolio Antonio
Jul/Aug 2016
Pg. 343-346

Sodium Nitroprusside and Sodium Thiosulfate Intravenous Admixture
Allen Loyd V Jr
Jan/Feb 2011
Pg. 71

Chemical Stability of Cefazolin Sodium after Reconstituting in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D
Mar/Apr 2003
Pg. 152-154

Oxacillin Sodium 167-mg/mL Injection
Allen Loyd V Jr
Nov/Dec 2014
Pg. 502

Stability of Diphenhydramine Hydrochloride, Lorazepam, and Dexamethasone Sodium Phosphate in 0.9% Sodium Chloride Stored in Polypropylene Syringes
Anderson Collin R
, Halford Zachery, MacKay Mark
Jul/Aug 2015
Pg. 344-347

Return to Top