Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags

Breukels, Oscar; van, der Gronde Toon; Simons-Sanders, Kathleen; Crul, Mirjam

Abstract

Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags

Author(s): Breukels Oscar, van der Gronde Toon, Simons-Sanders Kathleen, Crul Mirjam

Issue: Jul/Aug 2018 - Volume 22, Number 4

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Page(s): 345-349

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Abstract

Eight Dutch hospital pharmacies took wipe samples of prepared infusion bags containing 5 fluorouracil just before distribution to the wards. The samples were tested with high-performance liquid chromatography and triple quadrupole mass spectroscopy. The limit of detection was 10 ng per swipe. None of the 146 samples had a detectable amount of 5-fluorouracil. The outside of infusion bags containing antineoplastic drugs prepared in these eight Dutch hospital pharmacies were not contaminated and, therefore, were not a risk factor with regard to exposure of hospital workers to antineoplastic drugs.

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