Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags

Breukels, Oscar; van, der Gronde Toon; Simons-Sanders, Kathleen; Crul, Mirjam

A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

LEARN MORE

Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags

Author(s): Breukels Oscar, van der Gronde Toon, Simons-Sanders Kathleen, Crul Mirjam

Issue: Jul/Aug 2018 - Volume 22, Number 4
View All Articles in Issue

Page(s): 345-349

Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags Page 1

Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags Page 2

Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags Page 3

Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags Page 4

Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags Page 5

Download in electronic PDF format for $75

Abstract: Eight Dutch hospital pharmacies took wipe samples of prepared infusion bags containing 5 fluorouracil just before distribution to the wards. The samples were tested with high-performance liquid chromatography and triple quadrupole mass spectroscopy. The limit of detection was 10 ng per swipe. None of the 146 samples had a detectable amount of 5-fluorouracil. The outside of infusion bags containing antineoplastic drugs prepared in these eight Dutch hospital pharmacies were not contaminated and, therefore, were not a risk factor with regard to exposure of hospital workers to antineoplastic drugs.

Related Keywords: Oscar Breukels, PharmD, Toon van der Gronde, PharmD, Kathleen Simons-Sanders, PharmD, Mirjam Crul, PharmD, PhD, hospital pharmacy, prepared infusion bags, 5-fluorouracil, compounded cytotoxic agents, occupational exposure, workplace exposure, antineoplastic drugs, hazardous drugs, wipe tests, infusion bag contamination

Related Categories: CANCER AND AIDS, INFUSION, PACKAGING, PEER-REVIEWED, QUALITY CONTROL, HAZARDOUS DRUGS

Printer-Friendly Version

Title/Author (Click for Abstract / Details / Purchase)	Issue/Page View/Buy
Related Articles from IJPC
Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags Breukels Oscar, van der Gronde Toon, Simons-Sanders Kathleen, Crul Mirjam	Jul/Aug 2018 Pg. 345-349
Incorporating Quality Assurance in Pharmaceutical Compounding-related Courses in the PharmD Curricula Hossain Mohammad Faisal, Levesque Dan, Frye John, Rashid Mamoon	Jul/Aug 2020 Pg. 322-326
Stability of Ampicillin Sodium, Nafcillin Sodium, and Oxacillin Sodium in AutoDose Infusion System Bags Zhang Yanping, Trissel Lawrence A	May/Jun 2002 Pg. 226-229
Stability of Dexmedetomidine in 0.9% Sodium Chloride in Two Types of Intravenous Infusion Bags Marquis Kathleen, Hohlfelder Benjamin, Szumita Paul M	Sep/Oct 2017 Pg. 436-439
Stability of Gentamicin Sulfate and Tobramycin Sulfate in AutoDose Infusion System Bags Xu Quanyun A, Trissel Lawrence A, Saenz Christopher A, Ingram Delshalonda S	Mar/Apr 2002 Pg. 152-154
Stability of Furosemide 5 mg/mL in Polypropylene Syringes van der Schaar JAJ, Grouls R, Franssen EJF, Crul M	Sep/Oct 2019 Pg. 414-417
Compounding for Diabetic Patients:An Interview with Paul Lofholm, PharmD Allen Loyd V Jr	Nov/Dec 1997 Pg. 381-385
In-use Stability of Ceftaroline Fosamil in Elastomeric Home Infusion Systems and MINI-BAG Plus Containers Bhattacharya Sisir, Parekh Satish, Dedhiya Mahendra	Sep/Oct 2015 Pg. 432-436
Physiochemical Stability of Diluted Trastuzumab Infusion Solutions in Polypropylene Infusion Bags Kaiser Jeanette, Kramer Irene	Nov/Dec 2011 Pg. 515-520
Safe Cytotoxic Drug Preparation Using a Closed-system Transfer Device: Technical and Practical Evaluation of a New Device (Vialshield/Texium) Comparatively to a Reference One (Phaseal) Garrigue Philippe, Montana Marc, Ventre Christophe, Savry Amadine, Gauthier-Villano Laurence, Pisano Pascale, Pourroy Bertrand	Mar/Apr 2016 Pg. 148-154
Stability of Extemporaneously Prepared Hydroxycarbamide Oral Suspensions Kabiche Djamila, Balde Issa-Bella, Majoul Elyes, Kabiche Sofiane, Bourguignon Elodie, Fontan Jean-Eudes, Cisternino Salvatore, Schlatter Joel	Mar/Apr 2017 Pg. 160-163
Zinc Content of Commercial Diluents Widely Use in Drug Admixtures Prepared for Intravenous Infusion Desai Narendra R, Shah Syed M, Koczone Julianna, Vencl-Joncic Maja, Sisto Christopher, Ludwig Stephen A	Sep/Oct 2007 Pg. 426-432
Stability of Dexmedetomidine in Polyvinyl Chloride Bags Containing 0.9% Sodium Chloride Intended for Subcutaneous Infusions Wolfe Amanda, Zhang Jeremy, Lapenskie Julie, Downar James, Kanji Salmaan	Jul/Aug 2021 Pg. 330-335
Extending Practical (In Use) Shelf Life of Oncology Drug Vials Using Spikes de Wilde Sofieke, Crul Mirjam, Breukels Oscar	Mar/Apr 2023 Pg. 154-159
Stability Studies of Fludrocortisone Acetate Capsules and Fludrocortisone Acetate Titrated Powders (Powder Triturates) Brandin Thibaut, Wasilewski Maya, Panuccio Camille, Bouguergour Cyrielle, Primas Nicolas, Lamy Edouard, Jean Christophe, Bertault-Peres Pierre, Rathelot Pascal, Curti Christophe, Vanelle Patrice	Mar/Apr 2022 Pg. 150-154
Finding the Right Balance: A Nationwide Study of Student Pharmacist Exposure to and Perceptions of Nonsterile Compounding Fredrickson Mary E, Belcher Faith G, Del Vecchio Kamryn N, Galleher Miranda N, Jugo Leila S, Gothard M David, Pallotta Raneem H, Pallotta Victor A Jr	May/Jun 2022 Pg. 242-247
Long-term Stability of Esomeprazole in 5% Dextrose Infusion Polyolefin Bags at 5°C ± 3°C after Microwave Freeze-thaw Treatment Hecq Jean-Daniel, Rolin Catherine, Godet Marie, Gillet Patricia, Jamart Jacques, Galanti Laurence M	Nov/Dec 2015 Pg. 521-524
Long-term Stability of Vancomycin Hydrochloride in Glucose 5% Polyolefin Bags: The Brand Name Versus a Generic Product Huvelle Sophie, Godet Marie, Hecq Jean-Daniel, Gillet Patricia, Jamart Jacques, Galanti Laurence M	Sep/Oct 2016 Pg. 416-420
Prolonged In-use Stability of Reconstituted Herceptin in Commercial Intravenous Bags Nalenz Heiko, Köpf Ellen, Dietel Elke	Sep/Oct 2018 Pg. 417-423
The Role of Compounding in Closing Therapeutic Gaps--Abstracts from FIP 2013 Lutz Eugene, Pauletti Giovanni, Carvalho Maria, Davidson Gigi, Ashworth Lisa, Subramaniam Vaiyapuri, Llambí Francesc	Jan/Feb 2014 Pg. 6-12
Return to Top