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Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags

Author(s):  Breukels Oscar, van der Gronde Toon, Simons-Sanders Kathleen, Crul Mirjam

Issue:  Jul/Aug 2018 - Volume 22, Number 4
View All Articles in Issue

Page(s):  345-349

Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags Page 1
Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags Page 2
Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags Page 3
Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags Page 4
Antineoplastic Drug Contamination on the Outside of Prepared Infusion Bags Page 5

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Abstract:  Eight Dutch hospital pharmacies took wipe samples of prepared infusion bags containing 5 fluorouracil just before distribution to the wards. The samples were tested with high-performance liquid chromatography and triple quadrupole mass spectroscopy. The limit of detection was 10 ng per swipe. None of the 146 samples had a detectable amount of 5-fluorouracil. The outside of infusion bags containing antineoplastic drugs prepared in these eight Dutch hospital pharmacies were not contaminated and, therefore, were not a risk factor with regard to exposure of hospital workers to antineoplastic drugs.

Related Keywords: Oscar Breukels, PharmD, Toon van der Gronde, PharmD, Kathleen Simons-Sanders, PharmD, Mirjam Crul, PharmD, PhD, hospital pharmacy, prepared infusion bags, 5-fluorouracil, compounded cytotoxic agents, occupational exposure, workplace exposure, antineoplastic drugs, hazardous drugs, wipe tests, infusion bag contamination

Related Categories: CANCER AND AIDS, INFUSION, PACKAGING, PEER-REVIEWED, QUALITY CONTROL, HAZARDOUS DRUGS

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