Abstract

Case Study: Personalized Oral Low-dose Naltrexone Titration for Pain Management

Author(s): Rodriguez Franklin, Carvalho Maria, Banov Fabiana

Issue: Nov/Dec 2023 - Volume 27, Number 6

Page(s): 468-473

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Abstract

Naltrexone is a competitive opioid receptor antagonist indicated to treat opioid and alcohol dependence. In the U.S., naltrexone is commercially available as 50-mg tablets, and the adult dosage strength typically ranges between 50 mg once daily and 100 mg once daily. However, there is evidence to suggest that naltrexone prescribed in low doses, about 1/10th of the daily standard dosage, may be effective in managing a myriad of chronic conditions, including pain refractory to conventional pharmacological treatments. The U.S. Food and Drug Administration recently granted an orphan drug designation for low-dose naltrexone for the treatment of complex regional pain syndrome. This article provides a case study of a patient who was treated with a low dose of naltrexone for pain associated with the diagnosis of idiopathic hypereosinophilic syndrome.

Related Keywords

  • low-dose naltrexone
  • formulation
  • pain management
  • complex regional pain syndrome
  • case report
  • idiopathic hypereosinophilic syndrome
  • mepolizumab
  • analgesia
  • inflammation
  • analgesic agent
  • anti-inflammatory agent
  • Neuropathic Pain Symptom Inventory
  • NPSI
  • dose titration
  • dose increases
  • patient assessment
  • pain intensity

Related Categories

  • FORMULATIONS
  • PAIN MANAGEMENT
  • CASE REPORTS
  • PATIENT ASSESSMENT

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