Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Effects of Calcium Polystyrene Sulfonate Formulation Change from Dry Syrup to Oral Solution in Patients with Chronic Kidney Disease

Author(s):  Kobayashi Shunsuke, Ogawara Yuka, Imamura Yoshihiko, Kitaoka Akira, Yasu Takeo

Issue:  Sep/Oct 2022 - Volume 26, Number 5
View All Articles in Issue

Abstract:  Calcium polystyrene sulfonate, a cation exchange resin preparation, is used to treat hyperkalaemia. The effects of switching from dry syrup to oral solution forms have been rarely evaluated. We investigated changes in serum potassium levels, incidence of adverse events, and patients’ perception and satisfaction associated with the change in calcium polystyrene sulfonate dosage forms from dry syrup to oral solution in chronic kidney disease patients. The study population was comprised of 24 patients. The chronic kidney disease cause, glomerular filtration rate category, and albuminuria category was G4 in 10 cases (41.7%) and G5 in 8 cases (33.3%). No significant difference was observed between groups before and after the change in dosage form. Contrastingly, the ease of intake (P=0.0047), taste (P=0.0056), and satisfaction (P<0.001) indicated positive significant improvements. Changing the calcium polystyrene sulfonate dosage form from dry syrup to oral solution in patients with chronic kidney disease improved patient satisfaction while maintaining efficacy and safety. For patients in whom weight gain is not a problem, we recommend changing the dosage form from dry syrup to oral solution for calcium polystyrene sulfonate.            

Related Keywords: Shunsuke Kobayashi, MSc, Yuka Ogawara, BS, Yoshihiko Imamura, MD, PhD, Akira Kitaoka, MSc, calcium polystyrene sulfonate, cation exchange resin, hyperkalemia, calcium, potassium, chronic kidney disease, dry syrup, oral solution, patient satisfaction, clinical study


Printer-Friendly Version

Download in electronic PDF format for $65

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Effects of Calcium Polystyrene Sulfonate Formulation Change from Dry Syrup to Oral Solution in Patients with Chronic Kidney Disease Kobayashi Shunsuke, Ogawara Yuka, Imamura Yoshihiko, Kitaoka Akira, Yasu Takeo Sep/Oct 2022 436-439 Buy
Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats Nani Marcel, Leone Andréia, Bom Vinícius Pedro, Buszinski Andrei Felipe, Oliveira de Souza Rebeca, Pinheiro Vanessa Alves, Danapoulos Panagiota, Swikidisa Rosita, Marquele-Oliveira Franciane, Cipriani Frade Marco Andrey, Berretta Andresa Aparecida, Nogueira Rodrigo José Lupatini Mar/Apr 2018 154-163 Buy
Basics of Compounding: Clinical Studies Allen Loyd V Jr Nov/Dec 2002 443-447 Buy
Physical Compatibility of Calcium Acetate and Potassium Phosphates in Parenteral Nutrition Solutions Containing Aminosyn II Zhang Yanping, Xu Quanyun, Trissel Lawrence A, Baker Mary B Sep/Oct 1999 415-420 Buy
Patient Satisfaction with Pharmacist Intervention and Consultation in HRT DiMaggio Jennifer Lyn, Reed-Kane Dana Jul/Aug 2003 258-263 Buy
Basics of Compounding for Raynaud's Disease Glasnapp Andrew Jul/Aug 2003 288-291 Buy
Conservative Management of Chronic Kidney Disease in Cats: Recommendations for Veterinarians and Compounding Pharmacists Meadows Richard L, Muller George Sep/Oct 2010 382-394 Buy
Chemical and Physical Compatibility of an Intravenous Solution of Epinephrine with Calcium Chloride Weeks Phillip A, Teng Yang, Wu Lei, Sun Mary, Yang Zhen, Chow Diana S-L Mar/Apr 2014 152-158 Buy
Long-term Physiochemical Stability of Concentrated Solutions of Salbutamol (Albuterol) in Polypropylene Syringes for Use in the Intensive Care Unit and in Obstetrics Lardinois Benjamin, Baltzis Alexandre, Delcave Charlotte, Soumoy Laura, Jamart Jacques, Bihin Benoît, Hecq Jean-Daniel, Galanti Laurence Sep/Oct 2019 434-437 Buy
A Simplified Extemporaneously Prepared Potassium Chloride Oral Solution Tannous Elias, Tal Yana, Amarny Kamal Sep/Oct 2016 438-439 Buy
Particle Measuring Systems - USP <797> Environmental Monitoring Solutions