Bacterial Endotoxins and Pyrogens
Download in electronic PDF format for $65
Abstract: The etiologic role of sterile injections in the development of pyrogenic reactions should be of concern to all pharmacists involved in aseptic compounding. In this article, the author discusses bacterial endotoxins, testing for pyrogens, pyrogenic reactions from the use of gentamicin for injection and intrathecal limits for pyrogens. He concludes that the use of pyrogen-free water is the single most important factor in reducing the risk of pyrogenic reactions. End-product testing for bacterial content, potency and endotoxin load ensures the effectiveness and safety of the compounded medication. Clinical concern can be reduced by adhering to quality-control guidelines for policy and procedures in daily practice.
Related Keywords:
Endotoxins, bacterial, Pyrogens, Horseshoe crab, Limulus amebocyte lysate LAL
| Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
Bacterial Endotoxins and Pyrogens
Jones Marty
|
Jul/Aug 2001
Pg. 259-263
|
Quality Control Analytical Methods: Pharmacopeial Bacterial Endotoxins Test Chapters
Dawson Michael E
|
Jul/Aug 2010
Pg. 317-320
|
Quality-Control Analytical Methods: Endotoxins: Essential Testing for Pyrogens in the Compounding Laboratory, Part 3: A Simplified Endotoxin Test Method for Compounded Sterile Preparations
Cooper James F
|
Jan/Feb 2011
Pg. 49-54
|
Quality Control Analytical Methods: Endotoxins: Essential Testing for Pyrogens in the Compounding Laboratory, Part 1
Dubczak John, Latta Kenneth S, Hedman Hilary, Smith Donald R
|
Sep/Oct 2010
Pg. 407-414
|
Basics of Compounding: Application of the United States Pharmacopeia Bacterial Endotoxins Test to Compounded Sterile Preparations
Dawson Michael F
|
Jan/Feb 2006
Pg. 36-39
|
Quality-Control Analytical Methods: Endotoxins: Essential Testing for Pyrogens in the Compounding Laboratory, Part 2
Cooper James F, Chakrabarty Kaushik, McGuire Jason, Zolner William J, Jones Vann, Hedman Hilary
|
Nov/Dec 2010
Pg. 493-506
|
Testing for Bacterial Endotoxins
Jelinek Todd
|
Sep/Oct 1998
Pg. 379
|
Establishing Benchmark Rates of Microbial and Bacterial Endotoxin Contamination for Radiopharmaceuticals Compounded in Commerical Nuclear Pharmacy Settings
Weatherman Kara D, Augustine Samuel, Christoff Jeffrey, Galbraith Wendy
|
Mar/Apr 2013
Pg. 168-174
|
Quality Assurance and Quality Control, Part 2
Akers Michael J
|
May/Jun 2015
Pg. 215-221
|
Stability Issues for Compounding Extemporaneously Prepared Oral Formulations for Pediatric Patients
Schotik Debora
|
Jan/Feb 2001
Pg. 9-12
|
Comparison of Endotoxin Testing Methods for Pharmaceutical Products
Joiner Timothy J, Kraus Paul F, Kupiec Thomas C
|
Nov/Dec 2002
Pg. 408-409
View Sample |
USP Chapter <797>: Practical Solutions for Microbiology, Sterility, and Pyrogen Testing
Caputo Ross A, Huffman Anne, Reich Robert
|
Jan/Feb 2005
Pg. 11-13
|
Quality Assurance and Quality Control, Part 1
Akers Michael J
|
Mar/Apr 2015
Pg. 121-124
|
Basics of Sterile Compounding: Intravenous Admixture Preparation, Part 12: United States Pharmacopeia Chapters Referenced in the Current United States Pharmacopeia Chapter <797> Pharmaceutical Compounding -- Sterile Preparations
Allen Loyd V Jr
|
Nov/Dec 2021
Pg. 491-496
|
Standard Operating Procedure: Calculating the Endotoxin Load in Compounded Sterile Preparations
Allen Loyd V Jr
|
Nov/Dec 2004
Pg. 466-467
|
Sterilization and Depyrogenation Principles and Methods
Akers Michael J
|
Jul/Aug 1999
Pg. 263-269
|
Basics of Sterile Compounding: Contamination Control
Akers Michael J
|
May/Jun 2015
Pg. 232-238
|
Quality Control Analytical Methods: End-preparation Assessments and Tests for Compounded Sterile Preparations
McElhiney Linda F
|
Jul/Aug 2013
Pg. 307-311
|
Depyrogenation Options for the Compounding Cleanroom
Weller Tom, Bell Jeff, Dullinger Roger, Allen Vern, Anthenat Bruce
|
Nov/Dec 2014
Pg. 446-454
|
Basics of Compounding: Unique and Special Characteristics of Sterile Dosage Forms
Akers Michael J
|
Nov/Dec 2014
Pg. 479-484
|
