Quantitation of Metoprolol Tartrate and Propranolol Hydrochloride in Pharmaceutical Dosage Forms: Stability of Metoprolol in an Aqueous Mixture
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Abstract: A stability-indicating high-performance liquid chromatography
assay method was developed to quantify metoprolol
tartrate in pharmaceutical dosage forms. The method can also
be used to quantify propranolol hydrochloride in injections and
tablets. It is precise and accurate with a percent relative standard
deviation of 0.9% for metoprolol and 0.7% for propranolol
based on five determinations. The use of a counterion
in the mobile phase is not required as described in the USPNF
method. Also, the procedure for extracting the drugs from
tablets is very simple and does not require mechanical shaking
for 30 minutes as described in the USP-NF. The new
method was used to study the stability of metoprolol in an aqueous
mixture. The drug was stable for at least 10 days when stored
at 25° C in amber-colored bottles. However, 10% of the drug
was not available due to adsorption onto the excipient. Solutions
to this problem have been recommended.
Related Keywords:
Metoprolol tartrate, and propranolol hydrochloride, Metoprolol tartrate, quantitation of in dosage forms, Metoprolol tartrate, stability of in an aqueous mixture, Propranolol hydrochloride, and metoprolol tartrate
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