Chemical Stability of Cyproheptadine Hydrochloride in an Oral Liquid Dosage Form
Download in electronic PDF format for $75
Abstract: The chemical stability of cyproheptadine hydrochloride in an oral liquid dosage form was studied by using a stability-indicating high-performance liquid chromatographic assay method that was developed in our laboratory. The concentrations of the drug were directly related to peak heights, with an R value of 0.991. The percent relative standard deviation based on five injections was 1.6. The products of decomposition and excipients present in the dosage forms did not interfere with the developed assay method. The mixture was stable for at least 180 days when stored in amber-colored glass bottles at room temperature. The pH value of the mixture remained constant at 3.7 after 180 days of storage, and the physical appearance of the formulation did not change during the study period.
Related Keywords:
Vishnu D. Gupta, PhD, cyproheptadine hydrochloride, antihistamine, stability
Related Categories:
PEER-REVIEWED, STABILITIES, COMPATIBILITIES, ALLERGY/IMMUNOLOGY/INFLAMMATION
Printer-Friendly Version
| Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
Chemical Stability of Cyproheptadine Hydrochloride in an Oral Liquid Dosage Form
Gupta Vishnu D
|
Jul/Aug 2007
Pg. 347-348
|
Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms
Gupta Vishnu D
|
Sep/Oct 2009
Pg. 445-446
|
Chemical Stability of Brompheniramine Maleate in an Oral Liquid Dosage Form
Gupta Vishnu D, Gupta Vikas S
|
Jan/Feb 2011
Pg. 78-80
|
Physicochemical and Microbiological Stability of Amitriptyline Hydrochloride Oral Liquid Dosage Forms in PCCA Base, SuspendIt
Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
|
Jul/Aug 2022
Pg. 342-351
|
Chemical Stability of Perphenazine in Two Commercially Available Vehicles for Oral Liquid Dosage Forms
Gupta Vishnu D
|
Jul/Aug 2008
Pg. 372-374
|
Compatibility of Baclofen, Carvedilol, Hydrochlorothiazide, Mercaptopurine, Methadone Hydrochloride, Oseltamivir Phosphate, Phenobarbital, Propranolol Hydrochloride, Pyrazinamide, Sotalol Hydrochloride, Spironolactone, Tacrolimus Monohydrate, Ursodeoxycholic Acid, and Vancomycin Hydrochloride Oral Suspensions Compounded with SyrSpend SF pH4
Polonini Hudson, da Silva Sharlene Loures, Brandão Marcos Antônio Fernandes, Bauters Tiene, De Moerloose Barbara, Ferreira Anderson de Oliveira
|
Nov/Dec 2018
Pg. 516-526
|
Chemical Stability of Isoniazid in an Oral Liquid Dosage Form
Gupta Vishnu D, Sood Arun
|
Mar/Apr 2005
Pg. 165-166
|
Stability of Oral Liquid Dosage Forms of Ethacrynic Acid
Gupta Vishnu D, Ling Jie
|
May/Jun 2001
Pg. 232-233
|
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Clonidine Hydrochloride Packaged in Plastic Syringes
Xu Quanyun A, Trissel Lawrence A, Pham Lien
|
Jan/Feb 2002
Pg. 66-69
|
Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Bupivacaine Hydrochloride Packaged in Plastic Syringes
Trissel Lawrence A, Xu Quanyun A, Pham Lien
|
Jan/Feb 2002
Pg. 70-73
|
Chemical Stability of Perphenazine in Oral Liquid Dosage Forms
Gupta Vishnu D
|
Nov/Dec 2005
Pg. 484-486
|
Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents
Gupta Vishnu D
|
May/Jun 2007
Pg. 259-261
|
Physicochemical Stability of Compounded Naltrexone Hydrochloride Solutions in PCCA Base SuspendIt
Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Nguyen Anh TQ, Morris Tommy C, Graves Richard A
|
Mar/Apr 2019
Pg. 157-162
|
Chemical Stability of Diphenhydramine Hydrochloride from an Elixir and Lidocaine Hydrochloride from a Viscous Solution when Mixed Together
Gupta Vishnu D
|
May/Jun 2006
Pg. 237-239
|
Physical and Chemical Stability of Hydromorphone Hydrochloride 1.5- and 80-mg/mL Packaged in Plastic Syringes
Trissel Lawrence A, Xu Quanyun A, Pham Lien
|
Jan/Feb 2002
Pg. 74-76
|
Stability of Oral Liquid Dosage Forms of Glycopyrrolate Prepared with the Use of Powder
Gupta Vishnu D
|
Sep/Oct 2003
Pg. 386-388
|
Stability of Azathioprine, Clonidine Hydrochloride, Clopidogrel Bisulfate, Ethambutol Hydrochloride, Griseofulvin, Hydralazine Hydrochloride, Nitrofurantoin, and Thioguanine Oral Suspensions Compounded with SyrSpend SF pH4
Polonini Hudson, Loures da Silva Sharlene, Neves Cunha Carolina, de Oliveira Ferreira Anderson, Anagnostou Korina, Dijkers Eli
|
May/Jun 2020
Pg. 252-262
|
Chemical Stability of Naltrexone Hydrochloride Injection
Gupta Vishnu D
|
May/Jun 2008
Pg. 274-275
|
Chemical Stability of Tramadol Hydrochloride Injection
Gupta Vishnu D
|
Mar/Apr 2008
Pg. 161-162
|
Physical and Chemical Stability of Palonosetron Hydrochloride with Topotecan Hydrochloride and Irinotecan Hydrochloride during Simulated Y-Site Administration
Trissel Lawrence A, Xu Quanyun A
|
May/Jun 2005
Pg. 238-241
|
| Return to Top |
