Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Formulation Development of Modafinil Sprinkle Dosage Form: Study on the Effect of Food on Dosage

Author(s):  Kumaravelrajan Rajagopal, Karthik B, Venkatasan Suba

Issue:  Nov/Dec 2022 - Volume 26, Number 6
View All Articles in Issue

Abstract:  Sprinkles, drug-containing pellets or granules that can be mixed with soft food before administration, may be administered either directly in the mouth, or mixed with a spoonful of cold or room temperature soft foods. In this study, attempts were made to develop a new oral sprinkle formulation for modafinil in granular form. In order to increase the oral bioavailability and taste masking to food taken along with the drug, modafinil-hydroxypropyl-beta-cyclodextrin complexes were prepared and evaluated. A molar ratio of 1:5 was optimized. In vitro drug-release studies showed a maximum drug release rate of 93%. In-use analysis study also showed that the drug release was more than 90% within 45 minutes. The formulation was found to be stable for 3 months under accelerated conditions.

Related Keywords: Rajagopal Kumaravelrajan, PhD, B. Karthik, MPharm, Suba Venkatesan, PhD, formulation development, modanifil, oral formulations, sprinkle dosage form, oral bioavailability, 2-benzhydryl sulfonyl ethanamine, narcolepsy, hydroxypropyl-beta-cyclodextrin, HPBCD inclusion complex, granules, food, taste masking


Printer-Friendly Version

Download in electronic PDF format for $65

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Formulation Development of Modafinil Sprinkle Dosage Form: Study on the Effect of Food on Dosage Kumaravelrajan Rajagopal, Karthik B, Venkatasan Suba Nov/Dec 2022 516-521 Buy
Women's Oral Health: Is There a Hormonal Link? Preckshot John Jan/Feb 2004 10-14 Buy
Stability of Oral Liquid Dosage Forms of Ethacrynic Acid Gupta Vishnu D, Ling Jie May/Jun 2001 232-233 Buy
Pediatric Compounding: Coloring Outside the Lines Preckshot John Jan/Feb 2001 6-8 Buy
Chemical Stability of Perphenazine in Two Commercially Available Vehicles for Oral Liquid Dosage Forms Gupta Vishnu D Jul/Aug 2008 372-374 Buy
A Compendium of Compounding Agents and Formulations, Part 5: Timolol and Beta-glucans Riepl Mike Sep/Oct 2022 364-368 Buy
Need for Appropriate Formulations for Children: The National Institute of Child Health and Human Development--Pediatric Formulations Initiative, Part 2 Giacoia George P, Taylor-Zapata Perdita, Mattison Donald May/Jun 2007 220-225 Buy
Stability Issues for Compounding Extemporaneously Prepared Oral Formulations for Pediatric Patients Schotik Debora Jan/Feb 2001 9-12 Buy
Comparison of Rheological and Sedimentation Behavior of Commercially Available Suspending Vehicles for Oral Pharmaceutical Preparations Visser J Carolina, ten Seldam Inge E J, van der Linden Isabella J, Hinrichs Wouter L J, Veenendaal Reinier F H, Dijkers Eli C F, Woerdenbag Herman J May/Jun 2018 247-251 Buy
Physicochemical and Microbiological Stability of Amitriptyline Hydrochloride Oral Liquid Dosage Forms in PCCA Base, SuspendIt Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A Jul/Aug 2022 342-351 Buy
Particle Measuring Systems - USP <797> Environmental Monitoring Solutions