Abstract

Formulation Development of Modafinil Sprinkle Dosage Form: Study on the Effect of Food on Dosage

Author(s): Kumaravelrajan Rajagopal, Karthik B, Venkatasan Suba

Issue: Nov/Dec 2022 - Volume 26, Number 6

Page(s): 516-521

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  • Formulation Development of Modafinil Sprinkle Dosage Form: Study on the Effect of Food on Dosage Page 1
  • Formulation Development of Modafinil Sprinkle Dosage Form: Study on the Effect of Food on Dosage Page 2
  • Formulation Development of Modafinil Sprinkle Dosage Form: Study on the Effect of Food on Dosage Page 3
  • Formulation Development of Modafinil Sprinkle Dosage Form: Study on the Effect of Food on Dosage Page 4
  • Formulation Development of Modafinil Sprinkle Dosage Form: Study on the Effect of Food on Dosage Page 5
  • Formulation Development of Modafinil Sprinkle Dosage Form: Study on the Effect of Food on Dosage Page 6

Abstract

Sprinkles, drug-containing pellets or granules that can be mixed with soft food before administration, may be administered either directly in the mouth, or mixed with a spoonful of cold or room temperature soft foods. In this study, attempts were made to develop a new oral sprinkle formulation for modafinil in granular form. In order to increase the oral bioavailability and taste masking to food taken along with the drug, modafinil-hydroxypropyl-beta-cyclodextrin complexes were prepared and evaluated. A molar ratio of 1:5 was optimized. In vitro drug-release studies showed a maximum drug release rate of 93%. In-use analysis study also showed that the drug release was more than 90% within 45 minutes. The formulation was found to be stable for 3 months under accelerated conditions.

Related Keywords

  • formulation development
  • modanifil
  • oral formulations
  • sprinkle dosage form
  • oral bioavailability
  • 2-benzhydryl sulfonyl ethanamine
  • narcolepsy
  • hydroxypropyl-beta-cyclodextrin
  • HPBCD inclusion complex
  • granules
  • food
  • taste masking

Related Categories

  • FORMULATIONS
  • PEER-REVIEWED
  • STABILITIES, COMPATIBILITIES
  • DOSAGE FORMS/DRUG CARRIERS

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