Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Stability of Allopurinol Suspension Compounded from Tablets

Author(s):  Alexander Kenneth S, Davar Nipun, Parker Gordon A

Issue:  Mar/Apr 1997 - Pediatric Care
View All Articles in Issue

Page(s):  128-131

Stability of Allopurinol Suspension Compounded from Tablets Page 1
Stability of Allopurinol Suspension Compounded from Tablets Page 2
Stability of Allopurinol Suspension Compounded from Tablets Page 3
Stability of Allopurinol Suspension Compounded from Tablets Page 4

Download in electronic PDF format for $75

Abstract:  The stability of allopurinol as an extemporaneous suspension compounded from tablets was studied. The allopurinol suspension (20 mg/mL) was prepared by incorporating pulverized 300-mg allopurinol tablets into the suspending vehicle containing sodium carboxymethylcellulose and magnesium aluminum silicate (Veegum® ). Lycasin (a syrup vehicle that is 75% maltilol) was added to this mixture. Appropriate antioxidants, preservatives, sweeteners and flavoring agents also were used. Samples of the suspension were stored in amber-colored glass bottles at 50°, 60°, 70° and 80°C. At various times during the 97-day study period, the concentration of allopurinol in each sample was determined by a stability-indicating high performance liquid chromatography assay procedure. At the same time, samples were inspected visually for signs of caking or settling and evaluated for redispersibility and pourability. The aqueous solubility of allopurinol as a function of temperature also was studied. It was found that the aqueous solubility of allopurinol increased with an increase in the temperature.

A zero-order reaction was assumed for the suspension. The kinetics of degradation were determined and the energy of activation and shelf-life were calculated using the Arrhenius plot. During the study period all samples remained homogeneous and showed no signs of caking or settling. The allopurinol suspension compounded from tablets was found to be pharmaceutically acceptable and easily pourable and redispersible. The energy of activation for the suspension was found to be 21.92 kcal/mol. The shelf-life (t90) of the suspension was found to be 8.3 years at room temperature.

Related Keywords: Allopurinol, aqueous solubility of at various temperatures, Allopurinol suspension, effect of temperature during storage of, Allopurinol suspension, formula for, Allopurinol suspension, stability of

Related Categories: GERIATRICS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Stability of Allopurinol Suspension Compounded from Tablets
Alexander Kenneth S
, Davar Nipun, Parker Gordon A
Mar/Apr 1997
Pg. 128-131

Physicochemical Stability of Compounded Allopurinol Suspensions in PCCA Base, SuspendIt
Pramar Yashoda V
, Mandal Tarun K, Bostanian Levon A, Le Giang, Morris Tommy C, Graves Richard A
Sep/Oct 2020
Pg. 413-419

Allopurinol Sodium 4-mg/mL Injection
Allen Loyd V Jr
Jul/Aug 2013
Pg. 328

Allopurinol 20 mg/mL in SyrSpend SF pH4
Allen Loyd V Jr
Sep/Oct 2019
Pg. 406

Stability of Allopurinol, Amitriptyline Hydrochloride, Carbamazepine, Domperidone, Isoniazid, Ketoconazole, Lisinopril, Naproxen, Paracetamol (Acetaminophen), and Sertraline Hydrochloride in SyrSpend SF PH4 Oral Suspensions
Polonini Hudson C
, Loures Sharlene, de Araujo Edson Peter, Brandão Marcos Antônio F, Ferreira Anderson O
Sep/Oct 2016
Pg. 426-434

Formulation Development and Stability Testing of Extemporaneous Suspension Prepared From Dapsone Tablets
Kaila Nitin
, El-Ries Mohamed, Riga A, Alexander Kenneth S, Dollimore D
May/Jun 2003
Pg. 233-239

Formulation and Accelerated Stability Studies for an Extemporaneous Suspension of Amiodarone Hydrochloride
Alexander Kenneth S
, Thyangarajapuram N
Sep/Oct 2003
Pg. 389-393

Allopurinol 20-mg/mL Oral Liquid
Allen Loyd V Jr
May/Jun 1997
Pg. 174

The Effect of Manufacturer on the Compounding of Omeprazole Suspensions and Their Stability Assessment
Meissner Svenja
, Bansal Mahima, Dela Cruz Paula Donamae, Hanning Sara, Svirskis Darren
Mar/Apr 2020
Pg. 140-147

Mean Kinetic Temperature for Controlled Room Temperature Drug Storage: Official Definitions and Example Calculations
Newton David W
Jul/Aug 2019
Pg. 281-287

Stability of Extemporaneously Prepared Hydroxycarbamide Oral Suspensions
Kabiche Djamila
, Balde Issa-Bella, Majoul Elyes, Kabiche Sofiane, Bourguignon Elodie, Fontan Jean-Eudes, Cisternino Salvatore, Schlatter Joel
Mar/Apr 2017
Pg. 160-163

Temozolomide Stability in Extemporaneously Compounded Oral Suspensions
Trissel Lawrence A
, Zhang Yanping, Koontz Susannah E
Sep/Oct 2006
Pg. 396-399

Physical and Chemical Stability of Budesonide Mucoadhesive Oral Suspensions (MucoLox)
Ip Kendice
, Carvalho Maria, Shan Ashley, Banov Daniel
Jul/Aug 2017
Pg. 322-329

Physicochemical and Microbiological Stability of Extemporaneously Compounded Hydrocortisone Oral Suspensions in PCCA Base, SuspendIt
Pramar Yashoda V
, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
Sep/Oct 2021
Pg. 431-439

Preparation and Stability Evaluation of Extemporaneous Oral Suspension of Valsartan Using Commercially Available Tablets
Zaid Abdel Naser
, Assali Mohyeddin, Qaddomi Aiman, Ghanem Mashhour, Zaaror Yara Abu
Mar/Apr 2014
Pg. 169-174

Stability of Metronidazole Suspensions
Donnelly Ronald F
, Ying James
May/Jun 2015
Pg. 248-251

Stability of Levothyroxine, Doxycycline, Hydrocortisone, and Pravastatin in Liquid Dosage Forms Stored at Two Temperatures
Nahata Milap C
Sep/Oct 2015
Pg. 428-431

Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Storms Meredith L
, Stewart James T, Warren Flynn W
Sep/Oct 2002
Pg. 388-390

Stability of Suspensions: Theoretical and Practical Considerations before Compounding
Hadziabdic Jasmina
, Elezovic Alisa, Rahic Ognjenka, Mujezin Indira, Vranic Edina
Jan/Feb 2015
Pg. 78-85

Stability of an Alcohol-free, Dye-free Hydrocortisone (2 mg/mL) Compounded Oral Suspension
Manchanda Arushi
, Laracy Melissa, Savji Taslim, Bogner Robin H
Jan/Feb 2018
Pg. 66-75

Return to Top