Stability of Allopurinol Suspension Compounded from Tablets
Author(s): Alexander Kenneth S, Davar Nipun, Parker Gordon A
Issue: Mar/Apr 1997 - Pediatric Care
View All Articles in Issue
Page(s): 128-131
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Abstract: The stability of allopurinol as an extemporaneous suspension
compounded from tablets was studied. The allopurinol suspension
(20 mg/mL) was prepared by incorporating pulverized 300-mg
allopurinol tablets into the suspending vehicle containing
sodium carboxymethylcellulose and magnesium aluminum silicate
(Veegum® ). Lycasin (a syrup vehicle that is 75% maltilol)
was added to this mixture. Appropriate antioxidants, preservatives,
sweeteners and flavoring agents also were used. Samples
of the suspension were stored in amber-colored glass bottles
at 50°, 60°, 70° and 80°C. At various times during the 97-day
study period, the concentration of allopurinol in each sample
was determined by a stability-indicating high performance liquid
chromatography assay procedure. At the same time, samples
were inspected visually for signs of caking or settling and
evaluated for redispersibility and pourability. The aqueous
solubility of allopurinol as a function of temperature also was
studied. It was found that the aqueous solubility of allopurinol
increased with an increase in the temperature.
A zero-order reaction was assumed for the suspension. The
kinetics of degradation were determined and the energy of activation
and shelf-life were calculated using the Arrhenius plot.
During the study period all samples remained homogeneous and
showed no signs of caking or settling. The allopurinol suspension
compounded from tablets was found to be pharmaceutically acceptable
and easily pourable and redispersible. The energy of
activation for the suspension was found to be 21.92 kcal/mol.
The shelf-life (t90) of the suspension was found to be 8.3 years
at room temperature.
Related Keywords:
Allopurinol, aqueous solubility of at various temperatures, Allopurinol suspension, effect of temperature during storage of, Allopurinol suspension, formula for, Allopurinol suspension, stability of
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