Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Stability of Nebulizer Admixtures

Author(s):  Blondino Frank E, Baker Matthew

Issue:  Jul/Aug 2005 - Human Hormone Replacement Therapy
View All Articles in Issue

Abstract:  There has been an increase in the compounding of admixed respiratory preparations for nebulization. These admixtures may improve patient convenience and compliance, but there are few data regarding the stability of these admixtures. In this study, four drugs from the four major respiratory therapeutic classes were evaluated. Each drug was formulated singularly and in a combination formulation. The physical and chemical stability of each formulation was evaluated under four storage conditions over the course of 8 weeks. The combination formulation was more stable than any of the individual formulations. The formulations stored under elevated temperatures were less stable than those stored at room temperature or in the refrigerator.

Related Keywords: Frank E. Blondino, PhD, RPh, Matthew Baker, respiratory drugs, admixtures, nebulized drugs, beta-agonists, corticosteroids, mast cell stabilizers, anticholinergics, stability, inhaled preparations


Printer-Friendly Version

Download in electronic PDF format for $65

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Stability of Nebulizer Admixtures Blondino Frank E, Baker Matthew Jul/Aug 2005 323-326 Buy
Quality Control: Personal Protective Equipment for Use When Handling Hazardous Drugs Dillon L R Jan/Feb 2020 30-36 Buy
Intravenous Admixture Preparation Considerations, Part 2: Incompatibilities and Factors Involved Allen Loyd V Jr Jan/Feb 2020 44-50 Buy
Physiochemical Compatibility of Nebulizable Drug Admixtures Containing Budesonide and Colistmethate or Hypertonic Saline Klemmer Anja, Krämer Irene, Kamin Wolfgang May/Jun 2013 254-261 Buy
Does Your Drug Expertise Include Clinical Pharmaceutics? Newton David W May/Jun 2016 202-206 Buy
Physicochemical Stability and Compatibility of Revefenacin (LAMA) and Formoterol Fumarate (LABA) Inhalation Solution Admixture Ngim Kenley, Patel Jalpa May/Jun 2020 242-245 Buy
Intravenous Admixture Preparation Considerations, Part 9-B: Error Prevention in Intravenous Admixture Preparation Allen Loyd V Jr May/Jun 2021 222-229 Buy
PreScription: 2017 Pharmacy Compounding Issues: The U.S. Food and Drug Administration, Harzardous Drugs, and Wasted Drugs Allen Loyd V Jr Sep/Oct 2017 356 Buy
Intravenous Admixture Preparation Considerations, Part 9-A: Error Prevention in Intravenous Admixture Preparation Allen Loyd V Jr Mar/Apr 2021 131-139 Buy
Intravenous Admixture Preparation Considerations, Part 8: Ready-to-Use Preparations Allen Loyd V Jr Jan/Feb 2021 31-38 Buy
Particle Measuring Systems - USP <797> Environmental Monitoring Solutions