Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Intravenous Admixture Preparation Considerations, Part 7: Stability Issues

Author(s):  Allen Loyd V Jr

Issue:  Nov/Dec 2020 - Volume 24, Number 6
View All Articles in Issue

Abstract:  Preparation of intravenous admixtures is a critical component of pharmaceutical compounding, especially in hospitals and other healthcare facilities. In addition to the considerations already covered in this series, stability is very important to ensure the patient receives the appropriate intact and effective drug and dictates the quantity that can be prepared in advance and how long the admixture can be stored and administered effectively. This article discusses the different issues involved in the stability of intravenous admixtures and methods of avoiding instability issues.

Related Keywords: Loyd V. Allen, Jr., PhD, RPh, intravenous drug admixtures, chemical stability, physical stability, microbiological stability, instability, compatibility, incompatibility, parenteral preparations, antioxidants, chelating agents, synergists, hydrolysis, oxidation, photolysis, reduction, complexation, preservatives, surfactants, suspending agents, solvents, polymorphs, crystallization, vaporization, adsorption, large-volume parenteral containers, small-volume parenteral containers, ready-to-use parenteral products, storage conditions, shelf life, Q10 method, beyond-use dates

Related Categories: PARENTERALS, STABILITIES, COMPATIBILITIES, STERILE PREPARATIONS

Printer-Friendly Version




Download in electronic PDF format for $45

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Intravenous Admixture Preparation Considerations, Part 7: Stability Issues Allen Loyd V Jr Nov/Dec 2020 473-478 Buy
Intravenous Admixture Preparation Considerations, Part 2: Incompatibilities and Factors Involved Allen Loyd V Jr Jan/Feb 2020 44-50 Buy
Basics: Excipients Used in Nonsterile Compounding, Part 4: Antioxidants and Chelating Agents Allen Loyd V Jr Jan/Feb 2020 38-43 Buy
Investigation of the Physical, Chemical, and Microbiological Stability of Oral Solutions Compounded with Herbals Khokhlova Kateryna O, Zdoryk Oleksandr A May/Jun 2018 240-246 Buy
Physicochemical Stability and Compatibility of Revefenacin (LAMA) and Formoterol Fumarate (LABA) Inhalation Solution Admixture Ngim Kenley, Patel Jalpa May/Jun 2020 242-245 Buy
Physicochemical and Microbiological Stabilities of Hydrocortisone in InOrpha Suspending Agent Studied Under Various Condition Bourget Philippe, Amin Alexandre, Vidal Fabrice, Pieyre Manon, Dosso El Ourmar, Beauvais Raphaelle, Loeuillet Richard Sep/Oct 2014 427-431 Buy
Formulation and Stability of Solutions Akers Michael J Jan/Feb 2016 41-45 Buy
Rapid-Dissolve Technology: An Interview With Loyd V. Allen, Jr., PhD, RPh Allen Loyd V Jr Nov/Dec 2003 449-450 Buy
Wetting and/or Solubilizing Agents, Featured Excipient: Allen Loyd V Jr Jul/Aug 2001 310-312 Buy
Sterile Basics: Intravenous Admixture Preparation Considerations, Part 5: pH Considerations Allen Loyd V Jr Jul/Aug 2020 305-309 Buy