Abstract

Chemical Stability of Desonide in Ear Drops

Author(s): Gupta Vishnu D

Issue: Jan/Feb 2007 - Pediatric Patients

Page(s): 79-81

Download in electronic PDF format for $75
  • Chemical Stability of Desonide in Ear Drops Page 1
  • Chemical Stability of Desonide in Ear Drops Page 2
  • Chemical Stability of Desonide in Ear Drops Page 3

Abstract

The stability of desonide in ear drops was studied by using stability-indicating high-performance liquid chromatographic assay method that was developed in our laboratory. The concentrations of the drug were directly related to peak heights, and the percent relative standard deviation based on five injections was 0.5. The products of decomposition and excipients present in the dosage forms did not interfere with the developed assay method. The mixture was stable for 180 days when stored in amber-colored glass bottles at room temperature. The physical appearance of the ear drops remained clear during the study period.

Related Keywords

  • PEER-REVIEWED ARTICLE, DESONIDE, EAR DROPS, DOSAGE FORMS, STABILITY, STORAGE CONDITIONS, INFLAMMATION, CORTICOSTEROIDS, STEROIDS, ANTI-INFLAMMATORY AGENTS, FORMULATIONS

Related Categories

  • EAR NOSE THROAT
  • PEER-REVIEWED
  • STABILITIES, COMPATIBILITIES
  • DOSAGE FORMS/DRUG CARRIERS
  • STORAGE

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
Jan/Feb 2007
Pg. 79-81
Chemical Stability of Desonide in Ear Drops
Author(s): Gupta Vishnu D
May/Jun 2003
Pg. 170-174
Five Compounds for Treating Diabetes-Related Conditions
Author(s): Meece Jerry
Jan/Feb 2004
Pg. 46-48
Basics of Compounding for Disorders of the External Ear
Author(s): Allen Loyd V Jr
Jul/Aug 2001
Pg. 310-312
Wetting and/or Solubilizing Agents, Featured Excipient:
Author(s): Allen Loyd V Jr
Jul/Aug 2011
Pg. 302-307
Treating Inner Ear Disorders with Intratympanic Drug Administration
Author(s): McElhiney Linda F
Jul/Aug 1998
Pg. 277
Swim Ear Drops ( "In Your Ear" )
Author(s): Nelson James L
Mar/Apr 2004
Pg. 101-105
Pluronic Lecithin Organogel for Local Delivery of Anti-Inflammatory Drugs
Author(s): Frankum James, Ramsay Dale, Das Nandita G, Das Sudip K
May/Jun 2007
Pg. 259-261
Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents
Author(s): Gupta Vishnu D
Jul/Aug 2003
Pg. 298
Desonide 0.05% Otic Liquid
Author(s): Allen Loyd V Jr
Sep/Oct 2019
Pg. 418-421
Measurement of Free Iodine in Different Formulations of Povidone-Iodine Eye Drops 5%
Author(s): Berisa Prado Silvia, Riestra Ayora Ana Cristina, Trelles Campa Adrián
Jul/Aug 2022
Pg. 336-341
Long-term Stability of Epitheliotropic Factors in Frozen Serum Eye Drops
Author(s): Sahyoun Jean-Yves, Cloutier Marc, Frenette Mathieu, Robert Marie-Claude
Jul/Aug 2017
Pg. 322-329
Physical and Chemical Stability of Budesonide Mucoadhesive Oral Suspensions (MucoLox)
Author(s): Ip Kendice, Carvalho Maria, Shan Ashley, Banov Daniel
May/Jun 2004
Pg. 185
Veterinary Antibiotic/Antifungal/Anti-Inflammatory Anesthetic Otic Drops
Author(s): Hinkle Amanda R, Newton Gail D
May/Jun 1999
Pg. 225
Veterinary Antibiotic/Antifungal/Anti-Inflammatory Anesthetic Otic Drop
Author(s): Allen Loyd V Jr
Sep/Oct 2014
Pg. 427-431
Physicochemical and Microbiological Stabilities of Hydrocortisone in InOrpha Suspending Agent Studied Under Various Condition
Author(s): Bourget Philippe, Amin Alexandre, Vidal Fabrice, Pieyre Manon, Dosso El Ourmar, Beauvais Raphaelle, Loeuillet Richard
Jul/Aug 2008
Pg. 372-374
Chemical Stability of Perphenazine in Two Commercially Available Vehicles for Oral Liquid Dosage Forms
Author(s): Gupta Vishnu D
Jan/Feb 2015
Pg. 73-77
Physicochemical and Microbiological Stability of Azathioprine in InOrpha Suspending Agent Studied Under Various Conditions
Author(s): Amin Alexandre, Bourget Philippe, Vidal Fabrice, Cartier Francois, Beauvais Raphaelle, Do Nascimento Afonso Veronica
Sep/Oct 2014
Pg. 418-426
Stability and In Vitro Toxicity of an Infliximab Eye Drop Formulation
Author(s): Robert Marie-Claude, Spurr-Michaud Sandra, Frenette Mathieu, Young David, Gipson Ilene K, Dohlman Claes H
May/Jun 2017
Pg. 215-220
Basics of Compounding: 3D Printing--Pharmacy Applications, Part 2
Author(s): Allen Loyd V Jr
Jan/Feb 2011
Pg. 78-80
Chemical Stability of Brompheniramine Maleate in an Oral Liquid Dosage Form
Author(s): Gupta Vishnu D, Gupta Vikas S