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Progesterone and Traumatic Brain Injury: A Review of Literature

Author(s):  Williams LaVonn A, Mead Jay H

Issue:  Jul/Aug 2008 - Hormone Replacement Therapy
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Abstract:  Progesterone has long been used as an effective therapy on the reproductive and endocrine systems. Almost all studies and therapy on hormone replacement have given estrogens the primary focus. Most of these studies do not include data to reflect what the test results would have been if 17b-estradiol had been tested with natural progesterone instead of synthetic medroxyprogesterone acetate. Moreover, evidence indicates that progesterone exerts neuroprotective effects on the central nervous system. Therefore, progesterone should be given more attention as an effective neurotrophic agent that could potentially play an important role in preventing motor, cognitive, and sensory impairments that can accompany senescence in both men and women.1 This article reviews some of the literature on progesterone as it relates to possible neuroprotective properties.

Related Keywords: LaVonn A. Williams, Jay H. Mead, MD, FASCP, progesterone, hormone replacement therapy, neurological disorders, nervous system, traumatic brain injury, head injury, literature review, neuroprotective


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