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Chemical Stability of Extemporaneously Compounded Omeprazole Formulations: A Comparison of Two Methods of Compounding

Author(s):  Garg Sanjay, Svirskis Darren, Al-Kabban Majid, Farhan Samer, Komeshi Mohammed, Lee Jacky, Liu Quincy, Naidoo Sacha, Kairuz Therese

Issue:  May/Jun 2009 - Pain Management
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Abstract:  Liquid preparations of omeprazole are compounded extemporaneously for patients who cannot tolerate or have difficulty with tablets or capsules, such as those with a nasogastric tube or jejunal or feeding tube, those with a swallowing disorder, and young children and the elderly. Recommendations for preparation of a liquid from the enteric-coated pellets of omeprazole capsules are available in the literature. The pellets are dissolved in a sodium bicarbonate solution; shaking is recommended to aid dissolution. Apparently some pharmacists crush the pellets to speed up the compounding process. The aim of this study was to investigate the chemical stability of omeprazole in extemporaneously compounded liquids prepared by the grinding and shaking methods. A high-performance liquid chromatographic method was developed for evaluation of chemical stability. Samples were stored at 2°C (refrigerated conditions) or 25°C/60% relative humidity and assayed for drug concentration at 0, 1, 2, 4, and 8 weeks. The method of pr

Related Keywords: Sanjay Garg, BPharm, MPharm, Darren Svirskis, BPharm, Majid Al-Kabban, BPharm, Samer Farhan, BPharm, Mohammad Komeshi, BPharm, Jacky Lee, BPharm, Quincy Liu, BPharm, Sacha Naidoo, BPharm, Therese Kairuz, DipPharm, MPharm, PhD, omeprazole, formulations, chemical stability, enteric coating

Related Categories: FORMULATIONS, GASTROENTEROLOGY, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, DOSAGE FORMS/DRUG CARRIERS, STORAGE

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