Quantitation of Metoprolol Tartrate and Propranolol Hydrochloride in Pharmaceutical Dosage Forms: Stability of Metoprolol in an Aqueous Mixture
Download in electronic PDF format for $75
Abstract: A stability-indicating high-performance liquid chromatography
assay method was developed to quantify metoprolol
tartrate in pharmaceutical dosage forms. The method can also
be used to quantify propranolol hydrochloride in injections and
tablets. It is precise and accurate with a percent relative standard
deviation of 0.9% for metoprolol and 0.7% for propranolol
based on five determinations. The use of a counterion
in the mobile phase is not required as described in the USPNF
method. Also, the procedure for extracting the drugs from
tablets is very simple and does not require mechanical shaking
for 30 minutes as described in the USP-NF. The new
method was used to study the stability of metoprolol in an aqueous
mixture. The drug was stable for at least 10 days when stored
at 25° C in amber-colored bottles. However, 10% of the drug
was not available due to adsorption onto the excipient. Solutions
to this problem have been recommended.
Related Keywords:
Metoprolol tartrate, and propranolol hydrochloride, Metoprolol tartrate, quantitation of in dosage forms, Metoprolol tartrate, stability of in an aqueous mixture, Propranolol hydrochloride, and metoprolol tartrate
| Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
Quantitation of Metoprolol Tartrate and Propranolol Hydrochloride in Pharmaceutical Dosage Forms: Stability of Metoprolol in an Aqueous Mixture
Gupta Vishnu D, Maswoswe J
|
Mar/Apr 1997
Pg. 125-127
|
Metoprolol Tartrate 1.25-mg/mL Oral Liquid
Allen Loyd V Jr
|
Sep/Oct 2011
Pg. 421
|
Metoprolol Tartrate 1-mg/mL Injection
Allen Loyd V Jr
|
Jul/Aug 2013
Pg. 333
|
Metoprolol Tartrate 10 mg/mL in SyrSpend SF pH4 Oral Suspension
Allen Loyd V Jr
|
Nov/Dec 2021
Pg. 503
|
Stability of Alprazolam, Atropine Sulfate, Glutamine, Levofloxacin, Metoprolol Tartrate, Nitrofurantoin, Ondansetron Hydrochloride, Oxandrolone, Pregabaline, and Riboflavin in SyrSpend SF pH4 Oral Suspensions
de Oliveira Ferreira Anderson, Polonini Hudson C, Loures da Silva Sharlene, Cerqueira de Melo Victor Augusto, de Andrade Laura, Fernandes Brandão Marcos Antônio
|
May/Jun 2017
Pg. 255-263
|
Metoprolol Tartrate 10-mg/mL Oral Liquid
Allen Loyd V Jr
|
May/Jun 1997
Pg. 180
|
Stability of Oral Liquid Dosage Forms of Ethacrynic Acid
Gupta Vishnu D, Ling Jie
|
May/Jun 2001
Pg. 232-233
|
Compatibility of Baclofen, Carvedilol, Hydrochlorothiazide, Mercaptopurine, Methadone Hydrochloride, Oseltamivir Phosphate, Phenobarbital, Propranolol Hydrochloride, Pyrazinamide, Sotalol Hydrochloride, Spironolactone, Tacrolimus Monohydrate, Ursodeoxycholic Acid, and Vancomycin Hydrochloride Oral Suspensions Compounded with SyrSpend SF pH4
Polonini Hudson, da Silva Sharlene Loures, Brandão Marcos Antônio Fernandes, Bauters Tiene, De Moerloose Barbara, Ferreira Anderson de Oliveira
|
Nov/Dec 2018
Pg. 516-526
|
Physicochemical and Microbiological Stability of Amitriptyline Hydrochloride Oral Liquid Dosage Forms in PCCA Base, SuspendIt
Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
|
Jul/Aug 2022
Pg. 342-351
|
Formulation Development of Modafinil Sprinkle Dosage Form: Study on the Effect of Food on Dosage
Kumaravelrajan Rajagopal, Karthik B, Venkatasan Suba
|
Nov/Dec 2022
Pg. 516-521
|
Chemical Stability of Cyproheptadine Hydrochloride in an Oral Liquid Dosage Form
Gupta Vishnu D
|
Jul/Aug 2007
Pg. 347-348
|
Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms
Gupta Vishnu D
|
Sep/Oct 2009
Pg. 445-446
|
Basics of Sterile Compounding: Biopharmaceutics of Injectable Dosage Forms
Akers Michael J
|
Jan/Feb 2017
Pg. 47-56
|
Chemical Stability of Perphenazine in Two Commercially Available Vehicles for Oral Liquid Dosage Forms
Gupta Vishnu D
|
Jul/Aug 2008
Pg. 372-374
|
Stability of Propranolol Hydrochloride in SyrSpend SF
Geiger Christine M, Voudrie Mark A II, Sorenson Bridget
|
Nov/Dec 2012
Pg. 513-515
|
Stability of Oral Liquid Dosage Forms of Glycopyrrolate Prepared with the Use of Powder
Gupta Vishnu D
|
Sep/Oct 2003
Pg. 386-388
|
Stability of an Oral Liquid Dosage Form of Trovafloxacin Mesylate and Its Quantitation in Tablets Using High-Performance Liquid Chromatography
Gupta Vishnu D
|
May/Jun 2000
Pg. 233-235
|
Basics of Compounding: Foam Dosage Forms
Allen Loyd V Jr
|
Jul/Aug 2013
Pg. 312-322
|
Basics of Compounding: Unique and Special Characteristics of Sterile Dosage Forms
Akers Michael J
|
Nov/Dec 2014
Pg. 479-484
|
Propranolol Hydrochloride 1-mg/mL Injection
Allen Loyd V Jr
|
Jul/Aug 2014
Pg. 330
|
| Return to Top |
