Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Transdermal Gels in the Treatment of Diabetic Neuropathy

Author(s):  Hodges Caroline J, Jones Thomas H, Willoughby David L

Issue:  Mar/Apr 2000 - Compounding for Diabetes Patients
View All Articles in Issue

Abstract:  Diabetic neuropathy refers to a large number of clinical syndromes affecting both the autonomic and peripheral nervous systems and both type 1 and type 2 diabetes patients. In this article, the authors place particular emphasis on the use of ketamine Pluronic lecithin organogels for treating diabetic neuropathy. They also discuss the etiology of diabetic neuropathy, its clinical presentation, pain management (glycemic control, tricyclic antidepressants, anticonvulsants, ketamine and autonomic agents) and provide three brief case reports describing the use of a polymedicine formula . They conclude that medications administered by transdermal gels are a viable option and potentially the most rewarding for a compounding pharmacist, as they allow pain relief with fewer adverse effects. The real challenge is deciding whether the patient should begin with the polymedicine formula or with ketamine 10% and amitriptyline 2%, with additional ingredients added as needed to determine the optimal combination of medications for analgesic effects. More research is needed to determine the best combination of agents.

Related Keywords: diabetic neuropathy, ketamine PLO gel, hyperglycemia, shooting pain, burning pain, allodynia, hyperpathia, glycemic control, tricyclic antidepressants, anticonvulsants, gabapentin, ketamine, NMDA receptor antagonist, phantom limb pain, clonidine, baclofen

Related Categories: DIABETES, WOUND CARE

Printer-Friendly Version

Download in electronic PDF format for $65

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Transdermal Gels in the Treatment of Diabetic Neuropathy Hodges Caroline J, Jones Thomas H, Willoughby David L Mar/Apr 2000 91-93 Buy
Topical Ketamine: A Review of the History, Mechanisms, Uses, Safety, and Future Rabi Joseph Mar/Apr 2016 107-113 Buy
Topical Medications for Orofacial Neuropathic Pain Bramwell Bethany L May/Jun 2010 200-203 Buy
Compounded Pain Formulations: What is the Evidence? Asbill Scott, Sweitzer Sarah M, Spigener Shuler, Romero-Sandoval Alfonso Jul/Aug 2014 278-286 Buy
Compounded Analgesic Therapy for Disorders of Movement: Arthritis, Neuropathic Pain, and Postpolio Syndrome Brown Scott, Erickson Brian, Muller George, Bryant-Snure Susan J, Mestayer Richard F III May/Jun 2010 182-192 Buy
Chronic Neuropathic Pain: Pharmacological Interventions in New Millennium Jones Marty Jan/Feb 2000 6-15 Buy
Ketamine for Pain in Hospice Patients Wood Robert M Jul/Aug 2000 253-254 Buy
Efficacy and Clinical Value of Commonly Used Ingredients in Pain Management Compounds: A Literature Review Beshay Sarah M, Rivera Gerard, Balthasar Jan, Florea Naomi Jul/Aug 2015 295-300 Buy
Ketamine Hydrochloride 5%, Gabapentin 10%, Clonidine Hydrochloride 0.2%, and Baclofen 2% in Lipoderm Allen Loyd V Jr May/Jun 2016 231 Buy
Topical Ketamine 10% for Neuropathic Pain in Spinal Cord Injury Patients: An Open-Label Trial Rabi Joseph, Minori Joshua, Abad Hasan, Lee Ray, Gittler Michelle Nov/Dec 2016 517-520 Buy
Particle Measuring Systems - USP <797> Environmental Monitoring Solutions