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The Basics of Compounding: Compounding Powder-Filled Capsules

Author(s):  Allen Loyd V Jr

Issue:  May/Jun 1999 - Compounding for Animals
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Abstract:  The capsule is probably the most versatile of all dosage forms. In this article, the author discusses composition, preparation methods/techniques (source of equipment and materials, preparation of the powder, selection of the right capsule size, capsule-filling devices, sealing capsules, cleaning and packaging), physicochemical uniqueness (incompatibilities, capsules within capsules, tablets within capsules), quality control, storage/labeling and stability. Tables provide information regarding weight, in milligrams, of different powders that can be contained in various sized capsules; bulk densities of typical pharmaceutical actives and excipients; approximate capacities of capsules in milliliters; and excipients that can be used to enhance compatibility of eutectic mixtures. An example formula is provided for Capsule With Dry Powder Fill. In summary, capsules are relatively easy to manufacture, and they are amenable to small-scale compounding by the pharmacist to prepare specific products for individual patients’ needs.

Related Keywords: gelatin, Rule of Sixes, fill volume, bulk density, Rule of Sevens, encapsulation, hand filling, machine filling, incompatibilities

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