Abstract

Quality-Control Analytical Methods: Osmolality and Osmometry

Author(s): Allen Loyd V Jr

Issue: Mar/Apr 2004 - Overview of USP Chapter <797>

Page(s): 143-145

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Abstract

The author begins by providing a list of seven uses for osmometry in pharmaceutical compounding. He then provides background information, discussing osmotic pressure, vapor-pressure lowering, boiling-point elevation and freezing-point depression. Other sections cover osmolality and tonicity, iso-osmotic and isotonic solutions, osmolarity and osmolality, and instrumentation (osmometers). He concludes that osmometry is a useful analytical tool for compounding pharmacists that can provide valuable quality-control information and that it is easy to use and relatively inexpensive.

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