Chemical Stability of Terbutaline Sulfate Injection After Diluting With Normal Saline When Stored at Room Temperature in Polyvinylchloride Bags
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Abstract: The stability of terbutaline sulfate (0.1 mg/mL) in
0.9% sodium cloride injection was studied at 25°C
when stored in polyvinylchloride bags, using a stabilityindicating
high-performance liquid chromatographic assay
method. The concentrations of the drug were directly
related to peak heights, and percent relative standard deviation
based on five injections was 1.0. The drug decomposed
when boiled after adding sodium hydroxide, and the
products of decomposition did not interfere with the assay
procedure. The injection did not lose any potency after
23 days of storage at 25°C, and the pH value of 4.3 did not
change. The physical appearance of the injection remained
clear throughout the study period.
Related Keywords:
Vishnu D. Gupta, PhD, HPLC, PVC
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