Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Chemical Stability of Metoclopramide Hydrochloride Injection Diluted with 0.9% Sodium Chloride Injection in Polypropylene Syringes at Room Temperature

Author(s):  Gupta Vishnu D

Issue:  Jan/Feb 2005 - Sterile Preparations
View All Articles in Issue

Page(s):  72-74

Chemical Stability of Metoclopramide Hydrochloride Injection Diluted with 0.9% Sodium Chloride Injection in Polypropylene Syringes at Room Temperature Page 1
Chemical Stability of Metoclopramide Hydrochloride Injection Diluted with 0.9% Sodium Chloride Injection in Polypropylene Syringes at Room Temperature Page 2
Chemical Stability of Metoclopramide Hydrochloride Injection Diluted with 0.9% Sodium Chloride Injection in Polypropylene Syringes at Room Temperature Page 3

Download in electronic PDF format for $65

Abstract:  The stability of metoclopramide hydrochloride (0.5 mg/mL) in 0.9% sodium chloride injection in polypropylene syringes was studied at 25 degrees C, using a stability-indicating high-performance liquid chromatographic assay method. The concentrations of the drug were directly related to peak heights, and the percent relative standard deviation based on five injections was 1.4. The drug decomposed when treated with sodium hydroxide or hydrochloric acid, and the products of decomposition did not interfere with the assay procedure. The injection did not lose any potency after 21 days of storage at 25 degrees C, and the pH value of 5.0 did not change. The physical appearance of the injection remained clear throughout the study period.

Related Keywords: Vishnu D. Gupta, PhD, metoclopramide hydrochloride, stability, gastrointestinal motility, prokinetic, children

Related Categories: GASTROENTEROLOGY, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, ENDOCRINOLOGY/HORMONES/ MENOPAUSE/ANDROPAUSE

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Chemical Stability of Metoclopramide Hydrochloride Injection Diluted with 0.9% Sodium Chloride Injection in Polypropylene Syringes at Room Temperature
Gupta Vishnu D
Jan/Feb 2005
Pg. 72-74

Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Storms Meredith L
, Stewart James T, Warren Flynn W
Sep/Oct 2002
Pg. 388-390

Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection
Zhang Yan-ping
, Trissel Lawrence A
Mar/Apr 1997
Pg. 132-134

Stability of Neostigmine Methylsulfate Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Storms Meredith L
, Stewart James T, Warren Flynn W
Nov/Dec 2002
Pg. 475-477

Chemical Stability of Phenylephrine HCl After Reconstitution in 0.9% Sodium Chloride Injection for Infusion
Gupta Vishnu D
Mar/Apr 2004
Pg. 153-155

Physical and Chemical Stability of Trepostinil Sodium Injection Packaged in Plastic Syringe Pump Reservoirs.
Xu Quanyun A
, Trissel Lawrence A, Pham Lien
May/Jun 2004
Pg. 228-230

Stability of Tubocurarine Chloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Stewart James T
, Storms Meredith L, Warren Flynn W
Jul/Aug 2002
Pg. 308-310

Stability of Succinylcholine Chloride Injection at Ambient Temperature and 4 Degree C in Polypropylene Syringes
Storms Meredith L
, Stewart James T, Warren Flynn W
Jan/Feb 2003
Pg. 68-70

Stability of Dalteparin 1,000 Unit/mL in 0.9% Sodium Chloride for Injection in Polypropylene Syringes
Kirkham Kylian
, Munson Jessica M, McCluskey Susan V, Graner Kevin K
Sep/Oct 2017
Pg. 426-429

Stability of Cefepime Hydrochloride Dextrose in 5% Dextrose Injection and 0.9% Sodium Chloride Injection
Gupta Vishnu D
, Maswoswe J, Bailey RE
Nov/Dec 1997
Pg. 435-436

Stability of Levothyroxine Sodium Injection in Polypropylene Syringes
Gupta Vishnu D
Nov/Dec 2000
Pg. 482-483

Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Clonidine Hydrochloride Packaged in Plastic Syringes
Xu Quanyun A
, Trissel Lawrence A, Pham Lien
Jan/Feb 2002
Pg. 66-69

Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Bupivacaine Hydrochloride Packaged in Plastic Syringes
Trissel Lawrence A
, Xu Quanyun A, Pham Lien
Jan/Feb 2002
Pg. 70-73

Physical and Chemical Stability of Hydromorphone Hydrochloride 1.5- and 80-mg/mL Packaged in Plastic Syringes
Trissel Lawrence A
, Xu Quanyun A, Pham Lien
Jan/Feb 2002
Pg. 74-76

Stability of Alatrofloxacin Mesylate in 5% Dextrose Injection and 0.45% Sodium-Chloride Injection
Gupta Vishnu D
, Bailey RE
Jan/Feb 2000
Pg. 66-68

Stability of Glycopyrrolate Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Storms Meredith L
, Stewart James T, Warren Flynn W
Jan/Feb 2003
Pg. 65-67

Chemical Stability of Cefuroxime Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D
Jul/Aug 2003
Pg. 310-312

Chemical Stability of Pyridoxine Hydrochloride 100-mg/mL Injection, Preservative Free
Gupta Vishnu D
Jul/Aug 2006
Pg. 318-319

Compatibility and Stability of Potassium Chloride and Magnesium Sulfate in 0.9% Sodium Chloride Injection and 5% Dextrose Injection Solutions
Quay Irene
, Tan Edward
Jul/Aug 2001
Pg. 323-324

Stability of Droperidol 0.625 mg/mL Diluted with 0.9% Sodium Chloride Injection and Stored in Polypropylene Syringes
McCluskey Susan V
, Lovely Jenna K
Mar/Apr 2011
Pg. 170-173