Stability of Extemporaneous Oral Ribavirin Liquid Preparation
Author(s): Chan John P, Tong Henry H Y, Chow Alber H L
Issue: Nov/Dec 2004 - Endotoxin
View All Articles in Issue
Page(s): 486-488
Download in electronic PDF format for $75
Abstract: Ribavirin is an antiviral agent commonly used in Hong Kong for the treatment of severe acute respiratory syndrome. The choice of oral ribavirin therapeutic products available in the local market is currently limited to capsules. The present study investigated the chemical stability of an oral ribavirin suspension (200 mg/5 mL) prepared extemporaneously from oral capsules using a sugar-free suspension formula. The suspension was subjected to stability testing at 4 degrees C for up to 28 days. Employing a validated stability-indicating high-performance liquid chromatographic method, the ribavirin content of the extemporaneous preparation has been demonstrated to exhibit negligible changes throughout the storage period. No degradation product was observable in all high-performance liquid chromatograms, suggesting that the suspension remained chemically stable under the stated conditions.
Related Keywords:
ribavirin, antiviral medication, severe acute respiratory syndrome, SARS, oral suspension
Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
Stability of Extemporaneous Oral Ribavirin Liquid Preparation
Chan John P, Tong Henry H Y, Chow Alber H L
|
Nov/Dec 2004
Pg. 486-488
|
Veterinary Transdermal Medications: A to Z
Davidson Gigi S
|
Mar/Apr 2003
Pg. 106-113
|
Ribavirin 40-mg/mL Suspension
Allen Loyd V Jr
|
Jul/Aug 2007
Pg. 334
|
Women's Oral Health: Is There a Hormonal Link?
Preckshot John
|
Jan/Feb 2004
Pg. 10-14
|
Formulation and Accelerated Stability Studies for an Extemporaneous Suspension of Amiodarone Hydrochloride
Alexander Kenneth S, Thyangarajapuram N
|
Sep/Oct 2003
Pg. 389-393
|
Preparation and Stability Evaluation of Extemporaneous Oral Suspension of Valsartan Using Commercially Available Tablets
Zaid Abdel Naser, Assali Mohyeddin, Qaddomi Aiman, Ghanem Mashhour, Zaaror Yara Abu
|
Mar/Apr 2014
Pg. 169-174
|
Stability of Ribavirin for Inhalation Packaged in Syringes or Glass Vials when Stored Frozen, Refrigerated, and at Room Temperature
Larson Bayli, Bushman Lane R, Casciano Matthew L, Oldland Alan R, Kiser Jennifer J, Kiser Tyree H
|
Nov/Dec 2016
Pg. 521-525
|
Pediatric Compounding: Coloring Outside the Lines
Preckshot John
|
Jan/Feb 2001
Pg. 6-8
|
Stability of Clopidogrel in Three Extemporaneously Compounded Oral Liquid Preparations
Yamreudeewong Weeranuj, Dolence Eric Kurt, Teixeira M Glaucia
|
Sep/Oct 2011
Pg. 435-437
|
Utilization of Compounded Medications in an Oral Medicine Practice
Stock Shannon, Rubino Katie, Woo Sook-Bon, Margolis Arthur, Thomas Irena, Aboalela Ali, Treister Nathaniel
|
Mar/Apr 2016
Pg. 155-158
|
Stability of Extemporaneous Oral Tramadol, Fluoxetine, and Doxycycline Suspensions in SyrSpend SF pH4
Espana B, Joseph-Tornabène F, Jaquet Cécile, Perrot S, Prouillac C
|
Jul/Aug 2020
Pg. 327-336
|
Physicochemical Stability of the Extemporaneous Ibuprofen Oral Suspension in "Wagner" Base
Spennacchio Antonio, Lopedota Angela, la Forgia Flavia, Fontana Sergio, Franco Massimo, Denora Nunzio
|
Jan/Feb 2023
Pg. 72-77
|
Stability of Oseltamivir in Various Extemporaneous Liquid Preparations
Ford Stephen M, Kloesel Lawson G, Grabenstein John D
|
Mar/Apr 2007
Pg. 164-176
|
Stability of Extemporaneously Prepared Hydroxycarbamide Oral Suspensions
Kabiche Djamila, Balde Issa-Bella, Majoul Elyes, Kabiche Sofiane, Bourguignon Elodie, Fontan Jean-Eudes, Cisternino Salvatore, Schlatter Joel
|
Mar/Apr 2017
Pg. 160-163
|
Basics of Compounding: Vehicles for Compounded Oral Liquid Medications: A Review
Cutaia Kara, Chablani Lipika, Zhao Fang
|
Nov/Dec 2018
Pg. 480-489
|
Formulation Development and Stability Testing of Extemporaneous Suspension Prepared From Dapsone Tablets
Kaila Nitin, El-Ries Mohamed, Riga A, Alexander Kenneth S, Dollimore D
|
May/Jun 2003
Pg. 233-239
|
Oral Liquid Vehicles, Featured Excipient:
Allen Loyd V Jr
|
Jan/Feb 2001
Pg. 65-67
|
Stability of an Alcohol-free, Dye-free Hydrocortisone (2 mg/mL) Compounded Oral Suspension
Manchanda Arushi, Laracy Melissa, Savji Taslim, Bogner Robin H
|
Jan/Feb 2018
Pg. 66-75
|
Compatibility of Flavoring Agents in Compounding Extemporaneous Omeprazole Oral Liquid
Chuong Monica, Taglieri Catherine A, Huang Szu Yu, Sariol Anthony, Kitigawa Reina, Barman Koushik, Mistry Amee, Harris Donna L, Kerr Stephen G
|
Nov/Dec 2019
Pg. 504-510
|
Temozolomide Stability in Extemporaneously Compounded Oral Suspensions
Trissel Lawrence A, Zhang Yanping, Koontz Susannah E
|
Sep/Oct 2006
Pg. 396-399
|
Return to Top |