Physicochemical Stability of the Extemporaneous Ibuprofen Oral Suspension in

Spennacchio, Antonio; Lopedota, Angela; la, Forgia Flavia; Fontana, Sergio; Franco, Massimo; Denora, Nunzio

A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

LEARN MORE

Physicochemical Stability of the Extemporaneous Ibuprofen Oral Suspension in "Wagner" Base

Author(s): Spennacchio Antonio, Lopedota Angela, la Forgia Flavia, Fontana Sergio, Franco Massimo, Denora Nunzio

Issue: Jan/Feb 2023 - Volume 27, Number 1
View All Articles in Issue

Page(s): 72-77

Physicochemical Stability of the Extemporaneous Ibuprofen Oral Suspension in

Download in electronic PDF format for $75

Abstract: This article discusses a new method for the preparation of extemporaneous ibuprofen-based suspensions for use in paediatric patients. This method allows the preparation of extemporaneous suspensions up to concentrations of 200 mg/5 mL by using a liquid base named “Wagner.” A comprehensive physicochemical stability study was conducted on the formulation at a drug concentration of 200 mg/5 mL by performing high-pressure liquid chromatography and Turbiscan analyses. Chromatographic analyses of the samples demonstrated the chemical stability of the active pharmaceutical ingredient in the base for more than 90 days when the formulations were stored at 4°C and 25°C. Visual and optical analyses evidenced a reversible, slightly creaming phenomenon when the formulations were stored at 4°C or 25°C restoring the initial suspension by simply shaking.

Related Keywords: Antonio Spennacchio, PhD Student in Pharmaceutical Technology, Angela Lopedota, PhD in Pharmaceutical Technology, Flavia la Forgia, Master's Degree in Pharmacy, Sergio Fontana, Master's Degree in Pharmacy, Massimo Franco, PhD in Pharmaceutical Technology, Nunzio Denora, PhD in Pharmaceutical Technology, ibuprofen, oral suspensions, Wagner base, physical stability, chemical stability, nonsteroidal anti-inflammatory drugs, NSAID, children, formulation

Related Categories: EXCIPIENTS, PAIN MANAGEMENT, PEDIATRICS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version

Title/Author (Click for Abstract / Details / Purchase)	Issue/Page View/Buy
Related Articles from IJPC
Physicochemical Stability of the Extemporaneous Ibuprofen Oral Suspension in "Wagner" Base Spennacchio Antonio, Lopedota Angela, la Forgia Flavia, Fontana Sergio, Franco Massimo, Denora Nunzio	Jan/Feb 2023 Pg. 72-77
Extemporaneous Topical Minoxidil Solutions for the Treatment of Alopecia: Stability Studies and Incorporation Tests of Active Ingredients in ALOPLUS FAST Base Spennacchio Antonio, Lopedota Angela Assunta, Lopalco Antonio, Dibenedetto Maria Teresa, la Forgia Flavia Maria, Fontana Sergio, Franco Massimo, Denora Nunzio	May/Jun 2023 Pg. 256-262
Stability of Diazepam Enema Extemporaneous Formulation in Manzoni Base Lopalco Antonio, Lopedota Angela, Aurelio Fiorenza, la Forgia Flavia, Fontana Sergio, Franco Massimo, Denora Nunzio	Sep/Oct 2021 Pg. 427-430
Stability of Omeprazole Extemporaneous Oral Solution in Chopin Base Spennacchio Antonio, Lopedota Angela Assunta, la Forgia Flavia Maria, Fontana Sergio, Denora Nunzio, Lopalco Antonio	May/Jun 2023 Pg. 250-255
Rapid-Dissolve Technology: An Interview With Loyd V. Allen, Jr., PhD, RPh Allen Loyd V Jr	Nov/Dec 2003 Pg. 449-450
Physicochemical and Microbiological Stability of Extemporaneously Compounded Hydrocortisone Oral Suspensions in PCCA Base, SuspendIt Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A	Sep/Oct 2021 Pg. 431-439
Formulation and Pharmaceutical Evaluation of Extemporaneous α-arbutin Creams for the Treatment of Melasma Teeranachaideekul Veerawat, Boonsongsawat Worrawee, Asanawittaya Waralee, Jintapattanakit Anchalee, Chantasart Doungdaw, Wongrakpanich Amaraporn	Jan/Feb 2021 Pg. 62-72
Physicochemical and Microbiological Stability of Amitriptyline Hydrochloride Oral Liquid Dosage Forms in PCCA Base, SuspendIt Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A	Jul/Aug 2022 Pg. 342-351
Pharmacy Student Survey: Perceptions and Expectations of Pharmaceutical Compounding Carvalho Maria, Batra Bindhu	Jan/Feb 2015 Pg. 18-27
Physicochemical Stability of Compounded Naltrexone Hydrochloride Solutions in PCCA Base SuspendIt Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Nguyen Anh TQ, Morris Tommy C, Graves Richard A	Mar/Apr 2019 Pg. 157-162
Physicochemical and Microbiological Stability of Pyrimethamine in Paraben-free PCCA Base, SuspendIt Pramar Yashoda V, Mandal Tarum K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A	Mar/Apr 2023 Pg. 160-168
Physicochemical Stability of Compounded Allopurinol Suspensions in PCCA Base, SuspendIt Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Le Giang, Morris Tommy C, Graves Richard A	Sep/Oct 2020 Pg. 413-419
Formulation and Accelerated Stability Studies for an Extemporaneous Suspension of Amiodarone Hydrochloride Alexander Kenneth S, Thyangarajapuram N	Sep/Oct 2003 Pg. 389-393
Comparison of Rheological and Sedimentation Behavior of Commercially Available Suspending Vehicles for Oral Pharmaceutical Preparations Visser J Carolina, ten Seldam Inge E J, van der Linden Isabella J, Hinrichs Wouter L J, Veenendaal Reinier F H, Dijkers Eli C F, Woerdenbag Herman J	May/Jun 2018 Pg. 247-251
Physicochemical Stability of Compounded Amlodipine Besylate Suspensions in PCCA Base, SuspendIt Graves Richard A, Mandal Tarun K, Bostanian Levon A, Nguyen Anh TQ, Swopes Demikka, Morris Tommy C, Pramar Yashoda V	Nov/Dec 2019 Pg. 519-527
Physiochemical and Microbiological Stability of Azathioprine Suspensions in PCCA Base, SuspendIt Pramar Yahoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A	Jul/Aug 2023 Pg. 330-339
Physicochemical and Microbiological Stability of Compounded Metronidazole Suspensions in PCCA SuspendIt Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Le Giang, Morris Tommy C, Graves Richard A	Mar/Apr 2021 Pg. 169-175
Physicochemical Stability of an Oral Suspension of Trimethoprim 20 mg/mL in Combination with Sulfadiazine 200 mg/mL in PCCA Base SuspendIt Graves Richard A, Phan Kelly V, Bostanian Levon A, Mandal Tarun K, Pramar Yashoda V	Sep/Oct 2017 Pg. 430-435
Restructuring the Art of Health by Pharmacists: Formulation Designs with Oral Vehicles--Teaching Pharmacy Students Benischek Rita	Mar/Apr 2017 Pg. 105-108
Pharmaceutical Compounding or Pharmaceutical Manufacturing? A Regulatory Perspective Timko Robert J, Crooker Philip EM	Mar/Apr 2014 Pg. 101-111
Return to Top