Abstract

Stability of Oseltamivir in Various Extemporaneous Liquid Preparations

Author(s): Ford Stephen M, Kloesel Lawson G, Grabenstein John D

Issue: Mar/Apr 2007 - Diabetes

Page(s): 164-176

Download in electronic PDF format for $75
  • Stability of Oseltamivir in Various Extemporaneous Liquid Preparations Page 1
  • Stability of Oseltamivir in Various Extemporaneous Liquid Preparations Page 2
  • Stability of Oseltamivir in Various Extemporaneous Liquid Preparations Page 3
  • Stability of Oseltamivir in Various Extemporaneous Liquid Preparations Page 4
  • Stability of Oseltamivir in Various Extemporaneous Liquid Preparations Page 5
  • Stability of Oseltamivir in Various Extemporaneous Liquid Preparations Page 6
  • Stability of Oseltamivir in Various Extemporaneous Liquid Preparations Page 7
  • Stability of Oseltamivir in Various Extemporaneous Liquid Preparations Page 8
  • Stability of Oseltamivir in Various Extemporaneous Liquid Preparations Page 9
  • Stability of Oseltamivir in Various Extemporaneous Liquid Preparations Page 10
  • Stability of Oseltamivir in Various Extemporaneous Liquid Preparations Page 11
  • Stability of Oseltamivir in Various Extemporaneous Liquid Preparations Page 12
  • Stability of Oseltamivir in Various Extemporaneous Liquid Preparations Page 13

Abstract

The purpose of this study was to determine the stability of oseltamivir, the active ingredient in Tamiflu, in contemporaneously compounded suspensions for a period of not less than 90 days. The suspension vehicles provided for the study were chosen because of ease of preparation, commercial availability, and palatability. Stability of the active ingredient was demonstrated for suspensions prepared in PCCA-Plus, PCCA Acacia, and 1% methylcellulose and was independent of storage temperature (tested temperatures were 2oC to 8oC and 25oC). A control sample of the commercial liquid form of Tamiflu was prepared, stored, and analyzed along with the samples prepared from the contents of capsules. There was no difference in the apparent stability of the two forms of the drug preparation.

Related Keywords

  • histamine 1 receptor inhibitor
  • H1 blocker
  • sedation
  • oseltamivir
  • antiviral agent
  • viral infection
  • virus
  • influenza
  • oral suspension vehicles
  • stability
  • storage
  • formulations

Related Categories

  • EXCIPIENTS
  • FORMULATIONS
  • PEER-REVIEWED
  • STABILITIES, COMPATIBILITIES
  • INFECTIOUS DISEASE
  • STORAGE

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
Mar/Apr 2007
Pg. 164-176
Stability of Oseltamivir in Various Extemporaneous Liquid Preparations
Author(s): Ford Stephen M, Kloesel Lawson G, Grabenstein John D
Jul/Aug 2001
Pg. 310-312
Wetting and/or Solubilizing Agents, Featured Excipient:
Author(s): Allen Loyd V Jr
Sep/Oct 2003
Pg. 389-393
Formulation and Accelerated Stability Studies for an Extemporaneous Suspension of Amiodarone Hydrochloride
Author(s): Alexander Kenneth S, Thyangarajapuram N
Jan/Feb 2010
Pg. 82-85
Stability of Oseltamivir Phosphate in SyrSpend SF, Cherry Syrup, and SyrSpend SF (For Reconstitution)
Author(s): Voudrie Mark A II, Allen D Brett
Jul/Aug 2007
Pg. 332
Oseltamivir 12-mg/mL Oral Suspension
Author(s): Allen Loyd V Jr
Jan/Feb 2001
Pg. 65-67
Oral Liquid Vehicles, Featured Excipient:
Author(s): Allen Loyd V Jr
Mar/Apr 2016
Pg. 167-174
Stability of Atenolol, Clonazepam, Dexamethasone, Diclofenac Sodium, Diltiazem, Enalapril Maleate, Ketoprofen, Lamotrigine, Penicillamine-D, and Thiamine in SyrSpend SF PH4 Oral Suspensions
Author(s): Polonini HC, Loures S, Lima LC, Ferreira AO, Brandão MA
Sep/Oct 2014
Pg. 427-431
Physicochemical and Microbiological Stabilities of Hydrocortisone in InOrpha Suspending Agent Studied Under Various Condition
Author(s): Bourget Philippe, Amin Alexandre, Vidal Fabrice, Pieyre Manon, Dosso El Ourmar, Beauvais Raphaelle, Loeuillet Richard
Jul/Aug 2018
Pg. 323
Oseltamivir Phosphate 15 mg/mL in SyrSpend SF
Author(s): Allen Loyd V Jr
Nov/Dec 2018
Pg. 516-526
Compatibility of Baclofen, Carvedilol, Hydrochlorothiazide, Mercaptopurine, Methadone Hydrochloride, Oseltamivir Phosphate, Phenobarbital, Propranolol Hydrochloride, Pyrazinamide, Sotalol Hydrochloride, Spironolactone, Tacrolimus Monohydrate, Ursodeoxycholic Acid, and Vancomycin Hydrochloride Oral Suspensions Compounded with SyrSpend SF pH4
Author(s): Polonini Hudson, da Silva Sharlene Loures, Brandão Marcos Antônio Fernandes, Bauters Tiene, De Moerloose Barbara, Ferreira Anderson de Oliveira
May/Jun 2003
Pg. 233-239
Formulation Development and Stability Testing of Extemporaneous Suspension Prepared From Dapsone Tablets
Author(s): Kaila Nitin, El-Ries Mohamed, Riga A, Alexander Kenneth S, Dollimore D
Nov/Dec 2019
Pg. 504-510
Compatibility of Flavoring Agents in Compounding Extemporaneous Omeprazole Oral Liquid
Author(s): Chuong Monica, Taglieri Catherine A, Huang Szu Yu, Sariol Anthony, Kitigawa Reina, Barman Koushik, Mistry Amee, Harris Donna L, Kerr Stephen G
Jul/Aug 2020
Pg. 327-336
Stability of Extemporaneous Oral Tramadol, Fluoxetine, and Doxycycline Suspensions in SyrSpend SF pH4
Author(s): Espana B, Joseph-Tornabène F, Jaquet Cécile, Perrot S, Prouillac C
Mar/Apr 2014
Pg. 169-174
Preparation and Stability Evaluation of Extemporaneous Oral Suspension of Valsartan Using Commercially Available Tablets
Author(s): Zaid Abdel Naser, Assali Mohyeddin, Qaddomi Aiman, Ghanem Mashhour, Zaaror Yara Abu
Mar/Apr 2016
Pg. 159-163
Stability of Commercially Available Grape and Compounded Cherry Oral Vancomycin Preparations Stored in Syringes and Cups
Author(s): Kirk Loren, Lewis Paul, Luu Yao, Brown Stacy
Jul/Aug 2017
Pg. 322-329
Physical and Chemical Stability of Budesonide Mucoadhesive Oral Suspensions (MucoLox)
Author(s): Ip Kendice, Carvalho Maria, Shan Ashley, Banov Daniel
Nov/Dec 2004
Pg. 486-488
Stability of Extemporaneous Oral Ribavirin Liquid Preparation
Author(s): Chan John P, Tong Henry H Y, Chow Alber H L
Sep/Oct 2006
Pg. 324-328
Topical Cidofovir for Treatment of Resistant Viral Infections
Author(s): McElhiney Linda F
Jan/Feb 2023
Pg. 72-77
Physicochemical Stability of the Extemporaneous Ibuprofen Oral Suspension in "Wagner" Base
Author(s): Spennacchio Antonio, Lopedota Angela, la Forgia Flavia, Fontana Sergio, Franco Massimo, Denora Nunzio
May/Jun 2023
Pg. 250-255
Stability of Omeprazole Extemporaneous Oral Solution in Chopin Base
Author(s): Spennacchio Antonio, Lopedota Angela Assunta, la Forgia Flavia Maria, Fontana Sergio, Denora Nunzio, Lopalco Antonio