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Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen

Author(s):  Zugerman Jessie Jean M, Reed Thomas C

Issue:  Nov/Dec 2007 - High-Technology Compounding
View All Articles in Issue

Page(s):  514-519

Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen Page 1
Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen Page 2
Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen Page 3
Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen Page 4
Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen Page 5
Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen Page 6

Download in electronic PDF format for $75

Abstract:  The objective of this study was to assess perceived efficacy and patient satisfaction at a single point in time during a course of therapy with a compounded topical formulation containing at least ketoprofen in an anhydrous gel base. Patients aged 18 and older, currently using one of the topical pain relief compounds of interest obtained from Reed’s Compounding Pharmacy in Tucson, Arizona, were recruited and then interviewed (in person or by telephone). Data collected during patient interviews were recorded on a form designed solely for the purposes of this study. Interview questions pertained to the nature of the participants’ pain, their assessment of their pain both before treatment with the medication of interest and at the time of the interview, frequency and duration of use of the pain relief gel, disclosure of any other pain relief medications used at the time, and overall satisfaction with the medication. Interviews were conducted with a total of 50 patients who had chronic pain conditions representing several different etiologies and anatomical locations. The average pain assessment score at the time of the interview (representing perceived pain after use of the topical pain relief compound) was signficantly lower than the average before treatment pain assessment score (P<0.001). Perceived pain scores dropped by an average of 3.56 units after treatment with the gel (standard deviation, 2.28), or 44% (P<0.001). Neither increased frequency of application of the topical pain relief gel nor longer duration of use of the topical pain relief gel was associated with greater pain relief or changes in overall patient satisfaction with the preparation. Use of other pain relief medication(s) while undergoing treatment with the topical pain relief gel had no bearing on patient assessment of pain either before use of the gel or at the time of interview. The average overall rating of patient satisfaction with the topical pain relief product was 6.6 out of a possible 10 units (standard deviation, 3.13). Thirty-six patients (72%) rated their satisfaction with the topical medication of interest with a satisfaction score of 6, 10 patients (20%) rated their satisfaction with a score of 10 (completely satisfied), and 6 patients (12%) rated their satisfaction with a score of 0 (not at all satisfied). The lower the perceived pain assessment score at the time of the interview (after using the gel), the greater the patient satisfaction with the preparation. Moreover, the greater the difference between before-treatment and after-treatment pain assessment scores, the more satisfied with the preparation the patient was. Treatment of chronic pain with a topical pain relief compound containing at least ketoprofen in an anhydrous gel base is associated with patient satisfaction and perceived analgesic benefits. During the one-time interview, most patients reported a significant improvement in their pain relief, and the great majority of patients were very satisfied with the compounded topical treatment they received.

Related Keywords: Jessie Jean M. Zugerman, PharmD, Thomas C. Reed, RPh, pain control, pain relief, topical preparation, analgesia, analgesic, patient satisfaction, ketoprofen, formulation

Related Categories: PAIN MANAGEMENT, PEER-REVIEWED, DOSAGE FORMS/DRUG CARRIERS, PATIENT ASSESSMENT

Printer-Friendly Version



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Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen
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, Reed Thomas C
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Pg. 514-519

Patient Satisfaction with Pharmacist Intervention and Consultation in HRT
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Topical Ketamine 10% for Neuropathic Pain in Spinal Cord Injury Patients: An Open-Label Trial
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Pain Management in the Elderly
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NASEM Report on Compounded Topical Pain Creams
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May/Jun 2009
Pg. 218-219

Novel Approaches to Topical Psoriasis Therapy
Koyama Gregory
, Liu Jenny, Scaffidi Alyse, Khazraee Maryam, Epstein Benjamin
Sep/Oct 2015
Pg. 357-365

Return to Top

Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen

Author(s):  Zugerman Jessie Jean M, Reed Thomas C

Issue:  Nov/Dec 2007 - High-Technology Compounding
View All Articles in Issue

Page(s):  514-519

Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen Page 1
Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen Page 2
Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen Page 3
Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen Page 4
Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen Page 5
Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen Page 6

Download in electronic PDF format for $75

Abstract:  The objective of this study was to assess perceived efficacy and patient satisfaction at a single point in time during a course of therapy with a compounded topical formulation containing at least ketoprofen in an anhydrous gel base. Patients aged 18 and older, currently using one of the topical pain relief compounds of interest obtained from Reed’s Compounding Pharmacy in Tucson, Arizona, were recruited and then interviewed (in person or by telephone). Data collected during patient interviews were recorded on a form designed solely for the purposes of this study. Interview questions pertained to the nature of the participants’ pain, their assessment of their pain both before treatment with the medication of interest and at the time of the interview, frequency and duration of use of the pain relief gel, disclosure of any other pain relief medications used at the time, and overall satisfaction with the medication. Interviews were conducted with a total of 50 patients who had chronic pain conditions representing several different etiologies and anatomical locations. The average pain assessment score at the time of the interview (representing perceived pain after use of the topical pain relief compound) was signficantly lower than the average before treatment pain assessment score (P<0.001). Perceived pain scores dropped by an average of 3.56 units after treatment with the gel (standard deviation, 2.28), or 44% (P<0.001). Neither increased frequency of application of the topical pain relief gel nor longer duration of use of the topical pain relief gel was associated with greater pain relief or changes in overall patient satisfaction with the preparation. Use of other pain relief medication(s) while undergoing treatment with the topical pain relief gel had no bearing on patient assessment of pain either before use of the gel or at the time of interview. The average overall rating of patient satisfaction with the topical pain relief product was 6.6 out of a possible 10 units (standard deviation, 3.13). Thirty-six patients (72%) rated their satisfaction with the topical medication of interest with a satisfaction score of 6, 10 patients (20%) rated their satisfaction with a score of 10 (completely satisfied), and 6 patients (12%) rated their satisfaction with a score of 0 (not at all satisfied). The lower the perceived pain assessment score at the time of the interview (after using the gel), the greater the patient satisfaction with the preparation. Moreover, the greater the difference between before-treatment and after-treatment pain assessment scores, the more satisfied with the preparation the patient was. Treatment of chronic pain with a topical pain relief compound containing at least ketoprofen in an anhydrous gel base is associated with patient satisfaction and perceived analgesic benefits. During the one-time interview, most patients reported a significant improvement in their pain relief, and the great majority of patients were very satisfied with the compounded topical treatment they received.

Related Keywords: Jessie Jean M. Zugerman, PharmD, Thomas C. Reed, RPh, pain control, pain relief, topical preparation, analgesia, analgesic, patient satisfaction, ketoprofen, formulation

Related Categories: PAIN MANAGEMENT, PEER-REVIEWED, DOSAGE FORMS/DRUG CARRIERS, PATIENT ASSESSMENT

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen
Zugerman Jessie Jean M
, Reed Thomas C
Nov/Dec 2007
Pg. 514-519

Patient Satisfaction with Pharmacist Intervention and Consultation in HRT
DiMaggio Jennifer Lyn
, Reed-Kane Dana
Jul/Aug 2003
Pg. 258-263

Topical Ketamine 10% for Neuropathic Pain in Spinal Cord Injury Patients: An Open-Label Trial
Rabi Joseph
, Minori Joshua, Abad Hasan, Lee Ray, Gittler Michelle
Nov/Dec 2016
Pg. 517-520

Compounded Analgesic Therapy for Disorders of Movement: Arthritis, Neuropathic Pain, and Postpolio Syndrome
Brown Scott
, Erickson Brian, Muller George, Bryant-Snure Susan J, Mestayer Richard F III
May/Jun 2010
Pg. 182-192

Topical Medications for Orofacial Neuropathic Pain
Bramwell Bethany L
May/Jun 2010
Pg. 200-203

Current Topical Treatments in Wound Healing - Part 1
Helmke Christopher D
Jul/Aug 2004
Pg. 269-274

Efficacy and Clinical Value of Commonly Used Ingredients in Pain Management Compounds: A Literature Review
Beshay Sarah M
, Rivera Gerard, Balthasar Jan, Florea Naomi
Jul/Aug 2015
Pg. 295-300

Topical Ketamine: A Review of the History, Mechanisms, Uses, Safety, and Future
Rabi Joseph
Mar/Apr 2016
Pg. 107-113

A Brief Survey on Prescriber Beliefs Regarding Compounded Topical Pain Medications
Warner Meredith
, Tuder Dmitry
May/Jun 2014
Pg. 182-188

Pain Management in the Elderly
Peralta Alexander Jr
May/Jun 2004
Pg. 187-191

Compounded Pain Formulations: What is the Evidence?
Asbill Scott
, Sweitzer Sarah M, Spigener Shuler, Romero-Sandoval Alfonso
Jul/Aug 2014
Pg. 278-286

Topical Ketamine in the Treatment of Complex Regional Pain Syndrome
Durham Melissa J
, Mekhjian Hovik S, Goad Jeffery A, Lou Mimi, Ding Michelle, Richeimer Steven H
Mar/Apr 2018
Pg. 172-175

NASEM Report on Compounded Topical Pain Creams
Allen Loyd V Jr
Nov/Dec 2020
Pg. 446-448

Case Reports: Compounding to Relieve Arthritis Pain
Marshall Robert
, Vidaurri Vincent A, Boomsma Diane, Buchta Anthony J, Vail Jane
Nov/Dec 2008
Pg. 498-504

Stability of Morphine Sulfate in Polypropylene Infusion Bags for Use in Patient-Controlled Analgesia Pumps for Postoperative Pain Management
Nguyen-Xuan Tho
, Griffiths William, Kern Christian, Van Gessel Elisabeth, Bonnabry Pascal
Jan/Feb 2006
Pg. 69-73

Pain: Systematic Review of Pharmacy Compounding of Pain Medication
Shawaqfeh Mohammad S
, Harrington Catherine
Jan/Feb 2018
Pg. 19-24

Patient Satisfaction with Pharmacist Intervention and Consultation in Hormone Replacement Therapy: An Update
Hu Fei-Shu
, Reed-Kane Dana, Draugalis JoLaine R
May/Jun 2006
Pg. 187-192

Topical Treatment of Neuropathic Pain
Vadaurri Vince
May/Jun 2008
Pg. 182-190

Safe Use of Topical Local Anesthetic Medications for Pain Management
Epshteyn Mikhail G
, Pepin Steven M
May/Jun 2009
Pg. 218-219

Novel Approaches to Topical Psoriasis Therapy
Koyama Gregory
, Liu Jenny, Scaffidi Alyse, Khazraee Maryam, Epstein Benjamin
Sep/Oct 2015
Pg. 357-365

Return to Top