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Preparation and In Vitro Evaluation of a Pluronic Lecithin Organogel Containing Ricinoleic Acid for Transdermal Delivery

Author(s):  Boddu Sai HS, Bonam Sindhu Prabha, Wei Yangjie, Alexander Kenneth

Issue:  May/Jun 2014 - Volume 18, Number 3
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Abstract:  The present study deals with the preparation and in vitro evaluation of a Pluronic lecithin organogel gel containing ricinoleic acid for transdermal delivery. Blank Pluronic lecithin organogel gels were prepared using ricinoleic acid as the oil phase and characterized for pH, viscosity, gelation temperature, and microscopic structure. The optimized Pluronic lecithin organogel gel formulation was further evaluated using ketoprofen (10%) and dexamethasone (0.5%) as model drugs. The stability and in vitro permeability of ketoprofen and dexamethasone was evaluated and compared with the corresponding control formulation (Pluronic lecithin organogel gel made with isopropyl palmitate as the oil phase). The pH and viscosity of blank Pluronic lecithin organogel gel prepared with ricinoleic acid was comparable with the isopropyl palmitate Pluronic lecithin organogel gel. The thixotropic property of ricinoleic acid Pluronic lecithin organogel gel was found to be better than the control. Drug-loaded Pluronic lecithin organogel gels behaved in a similar manner and all formulations were found to be stable at 25°C, 35°C, and 40°C for up to 35 days. The penetration profile of dexamethasone was similar from both the Pluronic lecithin organogel gels, while the permeability for ketoprofen from Pluronic lecithin organogel gel containing ricinoleic acid was found to be three times higher as compared to the control formulation.

Related Keywords: Sai HS. Boddu, PhD, Sindhu Prabha Bonam, BS, Yangjie Wei, BS, Kenneth Alexander, PhD, ricinoleic acid, pluronic lecithin organogel, PLO, topical preparations, transdermal absorption, excipients, skin penetration, analgesic, analgesia, pain relief, inflammation, anti-inflammatory, transcutaneous permeability, stability, percutaneous absorption, permeation, potency, viscosity, dexamethasone, ketoprofen, gelation temperature


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