The Value of Near Infrared Spectroscopy in a Small Hospital Compounding Unit to Control the Risks Associated with Raw Materials
Author(s): Storme-Paris Isabelle, Storme Thomas, Thauvin Maxime, Brion Francoise, Chaminade Pierre, Rieutord Andre
Issue: Jan/Feb 2009 - Compounding for Pediatrics
View All Articles in Issue
Page(s): 81-86
Download in electronic PDF format for $75
Abstract: Pharmaceutical products, including capsules, oral suspensions, and solutions, are prepared by hospital pharmacists if no commercial product is available. Identification of the raw materials is a regulatory requirement before manufacturing (compounding). Because of the standard methods used, however, this is often time-consuming and laborious in a hospital setting. This article describes the use of near infrared spectroscopy in combination with chemometric methods for discrimination of raw materials. Sixty-three pulverized powder samples were discriminated by using reference samples (identity guaranteed by supplier and confirmed by mid infrared analyses) and NIRCal cluster analyses. A routine expert application involving optimized calibrations (n = 6) was developed, which allowed a rapid and nondestructive release procedure for every powder-based raw material received. This technique is superior to established identification analyses because of reduced quarantine times and cost savings.
Related Keywords:
raw materials, quality standards, near infrared spectroscopy, analytical testing, hospital pharmacy
Related Categories:
EXCIPIENTS, LEGAL, PEER-REVIEWED, TECHNOLOGY, QUALITY CONTROL, HOSPITAL PHARMACY
Printer-Friendly Version
Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
The Value of Near Infrared Spectroscopy in a Small Hospital Compounding Unit to Control the Risks Associated with Raw Materials
Storme-Paris Isabelle, Storme Thomas, Thauvin Maxime, Brion Francoise, Chaminade Pierre, Rieutord Andre
|
Jan/Feb 2009
Pg. 81-86
|
Using Hospital Laboratory Services to Perform Quality-control Testing on Compounded Preparations
Donnelly Ronald F
|
Sep/Oct 2015
Pg. 383-386
|
Quality Control: (Material) Safety Data Sheets
Allen Loyd V Jr
|
Mar/Apr 2017
Pg. 118-124
|
Quality-Control Analytical Methods: Designing a Quality-Control Potency Testing Program for a Compounding Pharmacy
Zolner William J
|
Sep/Oct 2009
Pg. 412-418
|
Quality Control Analytical Methods: End-preparation Assessments and Tests for Compounded Sterile Preparations
McElhiney Linda F
|
Jul/Aug 2013
Pg. 307-311
|
Applying Quality of Design Concepts to Pharmacy Compounding
Timko Robert J
|
Nov/Dec 2015
Pg. 453-463
|
Quality Control Analytical Methods: A Guide to Quality Control Testing for the Compounding Pharmacist
Zolner William J
|
Jul/Aug 2006
Pg. 281-284
|
Establishing a Quality-Assurance Program for Hospital Compounding
McElhiney Linda F
|
Mar/Apr 2008
Pg. 116-120
|
Quality-Control Analytical Methods: High-Performance Liquid Chromatography
Kupiec Thomas C
|
May/Jun 2004
Pg. 223-227
|
Quality-Control Analytical Methods: Gas Chromatography
Kupiec Thomas C
|
Jul/Aug 2004
Pg. 305-309
|
Quality-Control Analytical Methods: Selecting an Analytical Method
Allen Loyd V Jr
|
Jan/Feb 2004
Pg. 61-64
|
Quality Control Analytical Methods: Method Validation
Klang Mark G, Williams LaVonn A
|
Sep/Oct 2016
Pg. 381-386
|
Achievement of USP Chapter <797> Compliance by a 35-Bed Rural Hospital: A Case Study
Peters Gregory F, McKeon Marghi R, Nerbun Richard G
|
Nov/Dec 2007
Pg. 450-470
|
Quality Assurance and Quality Control, Part 1
Akers Michael J
|
Mar/Apr 2015
Pg. 121-124
|
Quality Control: Rapid Sterility Testing for Compounding Pharmacies
Taylor Andrew
|
Jul/Aug 2020
Pg. 299-303
|
Introduction to Quality Control in a Compounding Pharmacy
Allen Loyd V Jr
|
Nov/Dec 2016
Pg. 481-484
|
Auditing Safety of Compounding and Reconstituting of Intravenous Medicines on Hospital Wards in Finland
Suvikas-Peltonen Eeva, Palmgren Joni, Häggman Verner, Celikkayalar Ercan, Manninen Raija, Airaksinen Marja
|
Nov/Dec 2017
Pg. 518-529
|
Quality Control Analytical Methods: Microbial Limit Tests for Nonsterile Pharmaceuticals, Part 1
Vu Nicole, Lou Jessica R, Kupiec Thomas
|
May/Jun 2014
Pg. 213-221
|
Quality-Control Analytical Methods: In-House Quality Control of Simple Compounds
Trusley Craig
|
Nov/Dec 2007
Pg. 487-490
|
Records and Record-Keeping for the Hospital Compounding Pharmacist
McElhiney Linda F
|
Mar/Apr 2007
Pg. 138-143
|
Return to Top |