Evaluation of Extemporaneous Oral Itraconazole Suspensions by Dissolution Profiles Mapping
Author(s): Tong Henry H Y, Chan Hokman, Du Zhen, Zheng Ying
Issue: Jul/Aug 2010 - Sterile Compounding
View All Articles in Issue
Page(s): 342-345
Download in electronic PDF format for $75
Abstract: The objective of this study was to evaluate by dissolution profiles mapping five extemporaneous oral itraconazole suspensions reported in literature. Dissolution profiles of the extemporaneous oral itraconazole preparations were mapped and correlated with their reported clinical data therein. Four out of five extemporaneous preparations had either too early or insufficient release of itraconazole during dissolution study, potentially limiting the in vivo oral bioavailability in patients. Dissolution profile in the remaining extemporaneous preparation was closely similar to that in commercial itraconazole capsules. Based on the reported clinical data and dissolution results in this study, the extemporaneous preparation proposed in a study by Ong and Fobes seems to be the most reasonable choice for our patients. Dissolution profile evaluation is an important quality-control parameter during the evaluation of extemporaneous preparations by pharmacists.
Related Keywords:
Zhen Du, Mphil, itraconazole oral suspensions, antifungal agents, dissolution profile mapping, stability, bioavailability, literature review, formulations
Related Categories:
PEER-REVIEWED, STABILITIES, COMPATIBILITIES, QUALITY CONTROL, DOSAGE FORMS/DRUG CARRIERS, INFECTIOUS DISEASE, LITERATURE REVIEW
Printer-Friendly Version
Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
Evaluation of Extemporaneous Oral Itraconazole Suspensions by Dissolution Profiles Mapping
Tong Henry H Y, Chan Hokman, Du Zhen, Zheng Ying
|
Jul/Aug 2010
Pg. 342-345
|
Wetting and/or Solubilizing Agents, Featured Excipient:
Allen Loyd V Jr
|
Jul/Aug 2001
Pg. 310-312
|
Formulation and Accelerated Stability Studies for an Extemporaneous Suspension of Amiodarone Hydrochloride
Alexander Kenneth S, Thyangarajapuram N
|
Sep/Oct 2003
Pg. 389-393
|
Itraconazole 40-mg/mL Oral Liquid
Allen Loyd V Jr
|
Jul/Aug 2006
Pg. 301
|
Preparation and Stability Evaluation of Extemporaneous Oral Suspension of Valsartan Using Commercially Available Tablets
Zaid Abdel Naser, Assali Mohyeddin, Qaddomi Aiman, Ghanem Mashhour, Zaaror Yara Abu
|
Mar/Apr 2014
Pg. 169-174
|
Formulation Development and Stability Testing of Extemporaneous Suspension Prepared From Dapsone Tablets
Kaila Nitin, El-Ries Mohamed, Riga A, Alexander Kenneth S, Dollimore D
|
May/Jun 2003
Pg. 233-239
|
Stability of Extemporaneous Oral Tramadol, Fluoxetine, and Doxycycline Suspensions in SyrSpend SF pH4
Espana B, Joseph-Tornabène F, Jaquet Cécile, Perrot S, Prouillac C
|
Jul/Aug 2020
Pg. 327-336
|
Physicochemical Stability of the Extemporaneous Ibuprofen Oral Suspension in "Wagner" Base
Spennacchio Antonio, Lopedota Angela, la Forgia Flavia, Fontana Sergio, Franco Massimo, Denora Nunzio
|
Jan/Feb 2023
Pg. 72-77
|
Stability of Extemporaneously Prepared Hydroxycarbamide Oral Suspensions
Kabiche Djamila, Balde Issa-Bella, Majoul Elyes, Kabiche Sofiane, Bourguignon Elodie, Fontan Jean-Eudes, Cisternino Salvatore, Schlatter Joel
|
Mar/Apr 2017
Pg. 160-163
|
Physical and Chemical Stability of Budesonide Mucoadhesive Oral Suspensions (MucoLox)
Ip Kendice, Carvalho Maria, Shan Ashley, Banov Daniel
|
Jul/Aug 2017
Pg. 322-329
|
Women's Oral Health: Is There a Hormonal Link?
Preckshot John
|
Jan/Feb 2004
Pg. 10-14
|
Stability and Dissolution of Lozenge and Emulsion Formulations of Metronidazole Benzoate
Fan Bin, Stewart James T, White Catherine A
|
Mar/Apr 2001
Pg. 153-156
|
Stability of an Alcohol-free, Dye-free Hydrocortisone (2 mg/mL) Compounded Oral Suspension
Manchanda Arushi, Laracy Melissa, Savji Taslim, Bogner Robin H
|
Jan/Feb 2018
Pg. 66-75
|
Formulation and Stability Study of Eslicarbazepine Acetate Oral Suspensions for Extemporaneous Compounding
Zhao Fang, Dave Vivek S, Mar Mazin Z, Perri Jonathan R
|
Sep/Oct 2018
Pg. 433-439
|
Physicochemical and Microbiological Stability of Extemporaneously Compounded Hydrocortisone Oral Suspensions in PCCA Base, SuspendIt
Pramar Yashoda V, Mandal Tarun K, Bostanian Levon A, Kader Cyndy, Morris Tommy C, Graves Richard A
|
Sep/Oct 2021
Pg. 431-439
|
Nitazoxanide 20-mg/mL Oral Suspension
Allen Loyd V Jr
|
Sep/Oct 2023
Pg. 420
|
Profile of a Practice: Ward Drug Company Diabetic Shoppe and Prescription Compounding Center
Vail Jane
|
Jan/Feb 2003
Pg. 21-23
|
Formulation, Physical Stability, and the Clinical Effectiveness of Extemporaneous Ivermectin Oral Solution
Zaid Abdel-Naser, Zaaror Yara Abu, Qaddumi Aiman, Ratrout Ala, Ahmad Ayda, Hamad Emad, Kittana Naim
|
Nov/Dec 2021
Pg. 523-527
|
Pediatric Compounding: Coloring Outside the Lines
Preckshot John
|
Jan/Feb 2001
Pg. 6-8
|
Stability Issues for Compounding Extemporaneously Prepared Oral Formulations for Pediatric Patients
Schotik Debora
|
Jan/Feb 2001
Pg. 9-12
|
Return to Top |