Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Physical Stability and Release Profile of Compounded Gabapentin Containing Pluronic Lecithin Organogel for Neuropathic Pain Management

Author(s):  Hong Eun Ji, Sumanasekera Wasana, Le Uyen Minh

Issue:  Jan/Feb 2022 - Volume 26, Number 1
View All Articles in Issue

Abstract:  The objective of this study was to evaluate the physical stability and drug-release profile of gabapentin from different compounded formulations of Pluronic lecithin organogel containing gabapentin, thus confirming the stability of the preparations. Eight different formulations of compounded Pluronic lecithin organogel containing gabapentin alone or gabapentin in combination with other drugs were prepared using the cold incorporation method. Organoleptic properties, pH values, rheology, and gelation temperature were studied at 1, 7, and 14 days after preparation. The release of gabapentin out of Pluronic lecithin organogel was measured by diffusion across cellulose membranes (0.45 um) in the Franz diffusion cell system. The organoleptic properties were constant during the stability study in all formulations. The values of pH varied depending on the formulation, with slight increases after the the 7th day of the study. Gelation temperature, rheology, and drug release of gabapentin out of Pluronic lecithin organogel were remarkably dependent on the nature of combination in formulations during the time of assay. Formulations of Pluronic lecithin organogel containing only gabapentin or gabapentin with another drug were physically stable for 14 days. However, 3- and 4-combined drug formulations demonstrated an altered pseudoplastic behavior and instability during the study period.

Related Keywords: Eun Ji Hong, PharmD, Wasana Sumanasekara, PhD, Uyen Minh Le, PhD, gabapentin, topical preparations, physical stability, drug-release profile, pluronic lecithin organogels, PLO, drug combinations, drug-drug interactions, peripheral neuropathy, neuropathic pain, nerve pain, baclofen, amitriptyline, ketoprofen, gelation temperature

Related Categories: PAIN MANAGEMENT, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, DOSAGE FORMS/DRUG CARRIERS, NEUROLOGY

Printer-Friendly Version




Download in electronic PDF format for $55

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Physical Stability and Release Profile of Compounded Gabapentin Containing Pluronic Lecithin Organogel for Neuropathic Pain Management Hong Eun Ji, Sumanasekera Wasana, Le Uyen Minh Jan/Feb 2022 65-71 Buy
Pluronic Lecithin Organogel for Local Delivery of Anti-Inflammatory Drugs Frankum James, Ramsay Dale, Das Nandita G, Das Sudip K Mar/Apr 2004 101-105 Buy
Gabapentin in Elastic Liposomes: Preparation, Characterization, Drug Release, and Penetration Through Porcine Skin Le Uyen Minh, Baltzley Sarah, AlGhananeem Abeer Nov/Dec 2018 498-503 Buy
Topical Medications for Orofacial Neuropathic Pain Bramwell Bethany L May/Jun 2010 200-203 Buy
PreScription: 2017 Pharmacy Compounding Issues: The U.S. Food and Drug Administration, Harzardous Drugs, and Wasted Drugs Allen Loyd V Jr Sep/Oct 2017 356 Buy
Quality Control: Personal Protective Equipment for Use When Handling Hazardous Drugs Dillon L R Jan/Feb 2020 30-36 Buy
Bioavailability of Promethazine in a Topical Pluronic Lecithin Organogel: A Pilot Study Glisson James K, Wood Rebecca L, Kyle Patrick B, Cleary John D May/Jun 2005 242-246 Buy
Preparation and Evaluation of Sustained Drug Release from Pluronic Polyol Rectal Suppositories Anderson Derick, Amiji Mansoor M May/Jun 2001 234-237 Buy
The Use of Pluronic Lecithin Organogels in the Transdermal Delivery of Drugs Bramwell Bethany L, Williams LaVonn A Jan/Feb 2012 62-63 Buy
Does Your Drug Expertise Include Clinical Pharmaceutics? Newton David W May/Jun 2016 202-206 Buy