Ex Vivo Percutaneous Absorption of Ketamine, Bupivacaine, Diclofenac, Gabapentin, Orphenadrine, and Pentoxyifylline: Comparison of Versatile Cream vs. Reference Cream

Wang, Xuexuan; Black, Laura

Abstract

Ex Vivo Percutaneous Absorption of Ketamine, Bupivacaine, Diclofenac, Gabapentin, Orphenadrine, and Pentoxyifylline: Comparison of Versatile Cream vs. Reference Cream

Author(s): Wang Xuexuan, Black Laura

Issue: Nov/Dec 2013 - Volume 17, Number 6

View All Articles in Issue

Page(s): 520-525

Download in electronic PDF format for $75

Abstract

This ex vivo human percutaneous absorption study evaluated a set of six model drugs (ketamine hydrochloride, bupivacaine hydrochloride, diclofenac sodium, gabapentin, orphenadrine citrate, pentoxifylline) from two popular formulations for topically applied compounding preparations. The compounded preparations used in this study were Versatile cream and a reference cream. Each formulation was applied to human trunk skin mounted on Franz Diffusion Cells, 50 mg/chamber (or 28.2 mg/cm2). Serial dermal receiver solutions were collected for 48 hours. Analysis of the resultant data supports the concept that the Versatile base formulation provides improved characteristics relative to the reference base. This is of key importance where the patient does not show clinical improvement when a conventional topical delivery vehicle is used in the formulation. From the results, it is reasonable to anticipate that, relative to the reference formulation, the Versatile formulation provides enhanced transdermal delivery of some analgesic medications

Related Keywords

Related Categories

Printer-Friendly Version

Related Articles from IJPC

Issue/Page View/Buy	Title/Author (Click for Abstract / Details / Purchase)
Nov/Dec 2013 Pg. 520-525	Ex Vivo Percutaneous Absorption of Ketamine, Bupivacaine, Diclofenac, Gabapentin, Orphenadrine, and Pentoxyifylline: Comparison of Versatile Cream vs. Reference Cream Author(s): Wang Xuexuan, Black Laura
May/Jun 2012 Pg. 248-252	In Vitro Percutaneous Absorption of Ketoprofen and Testosterone: Comparison of Pluronic Lecithin Organogel vs. Pentravan Cream Author(s): Lehman Paul A, Raney Sam G
Jul/Aug 2014 Pg. 332-340	Evaluation of Percutaneous Absorption Performance for Human Female Sexual Steroids into Pentravan Cream Author(s): Polonini Hudson C, Brandão Marcos Antônio F, Ferreira Anderson O, Ramos Cristiano, Raposo Nádia R B
May/Jun 2016 Pg. 231	Ketamine Hydrochloride 5%, Gabapentin 10%, Clonidine Hydrochloride 0.2%, and Baclofen 2% in Lipoderm Author(s): Allen Loyd V Jr
Mar/Apr 2024 Pg. 135	Ketamine Hydrochloride 5%, Gabapentin 10%, Clonidine Hydrochloride 0.2%, and Baclofen 2% in Lipoderm Author(s): Allen Loyd V Jr
May/Jun 2016 Pg. 250-256	Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives Author(s): Trimble John, Light Bob
Jan/Feb 2002 Pg. 42	Clonidine HCl 0.2%, Gabapentin 6%, and Ketamine HCl 10% in a Pluronic Lecithin Organogel (PLO) Author(s): Allen Loyd V Jr
Jan/Feb 2002 Pg. 70-73	Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Bupivacaine Hydrochloride Packaged in Plastic Syringes Author(s): Trissel Lawrence A, Xu Quanyun A, Pham Lien
Mar/Apr 2000 Pg. 133	Ketamine HCl 10%, Gabapentin 6%, Baclofen 2%, Amitriptyline HCl 2% and Clonidine HCl 0.1% in PLO Author(s): Allen Loyd V Jr
May/Jun 2003 Pg. 171	Ketamine 10 %, Gabapentin 6%, and Nifedipine 2% in PLO Author(s): Meece Jerry
May/Jun 2004 Pg. 185	Clonidine HCl 0.2%/Gabapentin 6%/Ketamine HCl 10% in Pluronic Lecithin Organogel (PLO) Author(s): Hinkle Amanda R, Newton Gail D
Jul/Aug 2020 Pg. 320	Sumatriptan, Lidocaine Hydrochloride, Dexamethasone, Pentoxifylline, and Ibuprofen Transdermal Cream (Migraine Cream) Author(s): Allen Loyd V Jr
Jan/Feb 2012 Pg. 80-81	Chemical Stability of Pentoxifylline in a Topical Cream Author(s): Gupta Vishnu D
May/Jun 2012 Pg. 245	Orphenadrine Citrate 30-mg/mL Injection Author(s): Allen Loyd V Jr
Nov/Dec 2014 Pg. 504-511	Skin Penetration and Antinociception of Topical Gabapentin Formulations Author(s): Bryson Evan, Asbill Scott, Sweitzer Sarah
Nov/Dec 2019 Pg. 496-503	Compounded Topical Gabapentin for Neuropathic Pain: Does Choice of Base Affect Efficacy? Author(s): Shakshuki Ayah, Agu Remigius U
Nov/Dec 2018 Pg. 466-468	Case Study: Absorption of Testosterone Cream via Scrotal Delivery Author(s): Needham Shawn, Needham Shane
Mar/Apr 2021 Pg. 146-155	In Vitro Permeability, Irritability, and Release Evaluation of Commonly Used Topical Diclofenac Gel Preparations (1%, 5%, and 10%) Author(s): Kohan Hamed Gilzad, Baker David M, Sani Shabnam, Bielecki-Wilken Kathleen A, Ramirez Alfonso
Jul/Aug 2021 Pg. 336-343	Compatibility of Estradiol, Estriol, Estrone, Progesterone, and Testosterone Single Formulation in Fitalite, Versatile, or HRT Supreme Cream Base Author(s): Polonini Hudson C, Dijkers Eli, Ferreira Anderson O, Zander Clark, Taylor Sarah
Jan/Feb 2022 Pg. 55	Diclofenac Sodium 1%-15% Topical Gel Author(s): Allen Loyd V Jr