Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Extending Practical (In Use) Shelf Life of Oncology Drug Vials Using Spikes

Author(s):  de Wilde Sofieke, Crul Mirjam, Breukels Oscar

Issue:  Mar/Apr 2023 - Volume 27, Number 2
View All Articles in Issue

Page(s):  154-159

Extending Practical (In Use) Shelf Life of Oncology Drug Vials Using Spikes Page 1
Extending Practical (In Use) Shelf Life of Oncology Drug Vials Using Spikes Page 2
Extending Practical (In Use) Shelf Life of Oncology Drug Vials Using Spikes Page 3
Extending Practical (In Use) Shelf Life of Oncology Drug Vials Using Spikes Page 4
Extending Practical (In Use) Shelf Life of Oncology Drug Vials Using Spikes Page 5
Extending Practical (In Use) Shelf Life of Oncology Drug Vials Using Spikes Page 6

Download in electronic PDF format for $75

Abstract:  The global increase of use of oncology drugs combined with the higher costs of these drugs raise the question of how to reduce these costs. One way to reduce the costs is to reduce spillage by extending the beyond-use date by preserving remainders in the vial of (expensive) oncology drugs instead of wasting them. Therefore, we investigated if spikes, instead of the expensive closed-system transfer devices, can be used to extend the beyond-use date of drugs both at room temperature and in the refrigerator during seven days after reconstitution and partial fluid withdrawal of a vial. Six hundred vials containing concentrated tryptic soy broth were reconstituted with 10-mL of sodium chloride 0.9%, after which approximately 3 mL were removed from the vial and discarded using a regular spike for 300 vials and a MicroSpike for the other 300 vials. Subsequently, the vials were stored either at refrigerator temperature or at room temperature for seven days. After seven days, all six hundred vials were transported and incubated at a temperature of 30°C to 35°C for fourteen days. None of the six hundred vials used showed contamination, either punctured with a MicroSpike or with a regular spike, after storage of seven days at room temperature or in the refrigerator and two weeks of incubation. Conclusively, it can be stated that hospital pharmacies play an important role in keeping the high costs of oncology drugs as low as possible. This study shows that using a spike instead of a more expensive closed-system transfer device for preservation of the remainder of oncology drugs will further reduce spillage of expensive drugs resulting in lower healthcare costs.

Related Keywords: oncology drugs, cost reduction, beyond-use dates, drug vials, closed-system transfer devices, aseptic technique, worker protection, spikes, microbial contamination, microspikes, swan lock, sterility-preserving technique, cancer drugs

Related Categories: CANCER AND AIDS, PEER-REVIEWED, STERILE PREPARATIONS, TECHNOLOGY, HOSPITAL PHARMACY

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Extending Practical (In Use) Shelf Life of Oncology Drug Vials Using Spikes
de Wilde Sofieke
, Crul Mirjam, Breukels Oscar
Mar/Apr 2023
Pg. 154-159

Safe Cytotoxic Drug Preparation Using a Closed-system Transfer Device: Technical and Practical Evaluation of a New Device (Vialshield/Texium) Comparatively to a Reference One (Phaseal)
Garrigue Philippe
, Montana Marc, Ventre Christophe, Savry Amadine, Gauthier-Villano Laurence, Pisano Pascale, Pourroy Bertrand
Mar/Apr 2016
Pg. 148-154

Study of Microbiological Safety of 25 Oncology Drugs After Multiple Uses in Aseptic Conditions
Roy Julie
, Brault Julie, Joran Pierre, Metrop Raphael, Hildgen Patrice
Sep/Oct 2011
Pg. 428-434

Use of a Closed-system Drug Transfer Device (PhaSeal) and Impact on Preparation Time
Sanchez-Rubio Ferrandez J
, Lozano M C, Iglesias I, Sanchez-Rubio Ferrandez L, Rodriguez Vargas B, Moreno Diaz R
Sep/Oct 2012
Pg. 431-433

Evaluation of Closed-system Transfer Devices in Reducing Potential Risk for Surface Contamination Following Simulated Hazardous-drug Preparation and Compounding (Reprint)
Soefje Scott
, Rickabaugh Keith, Rajkumar Rahul, Wall Kathryn P
Jan/Feb 2022
Pg. 72-79

Choosing a Vial Processing Line for Aseptic Compounding: Part 1
Noorian Shaun
, Vahedi Navid
Jul/Aug 2016
Pg. 283-292

Hazardous Drug Enteral Device: A Closed System Device for Crushing and Dispersing Hazardous Drug Tablets for Enteral Administration
Lopez C Vidal
, Rios GL Quito
Sep/Oct 2022
Pg. 358-362

Evaluation of Closed-system Transfer Devices in Reducing Potential Risk for Surface Contamination Following Simulated Hazardous-drug Preparation and Compounding
Soefje Scott
, Rickabaugh Keith, Rajkumar Rahul, Wall Kathryn P
Nov/Dec 2021
Pg. 515-522

Roboticized Compounding of Oncology Drugs in a Hospital Pharmacy
Palma Elisabetta
, Bufarini Celestino
Sep/Oct 2014
Pg. 358-364

Quality Control: Personal Protective Equipment for Use When Handling Hazardous Drugs
Dillon L R
Jan/Feb 2020
Pg. 30-36

Beyond-use Date of Trimix: A Reproducible Stability Study Using Bracketing Design
Patel Gopesh
, Davis Countaney, Liu Yi, Ip Kendice, Debideen Krystal E, Anderson Stephanie, Byrne Robert, Herr Dylan, Rhoads Melissa Merrell, Caputo Ross, Banov Daniel, Bassani August S
Jan/Feb 2021
Pg. 73-81

Quality Control: How to Produce a Well-closed Sealed Vial in a Regulated CGMP Environment: Part 1
Higgins Doral (Neal) O
, Prudom Melanie J, Summers Amy
Jul/Aug 2021
Pg. 298-302

PreScription: 2017 Pharmacy Compounding Issues: The U.S. Food and Drug Administration, Harzardous Drugs, and Wasted Drugs
Allen Loyd V Jr
Sep/Oct 2017
Pg. 356

How to Qualify Container Closure Systems for Intended Use, Part 1
Kim Amy A
, Gehrmann Matthew R, McCaw James, McAndrew T Page
Nov/Dec 2019
Pg. 454-461

Basics of Compounding: Excipients Used in Nonsterile Compounding, Part 11: Drug Tastes: Innate, Induced, and Improved
Allen Loyd V Jr
Sep/Oct 2021
Pg. 396-400

Evaluation of the Efficacy and Superiority of Different Vial Rubber Closure Disinfection Techniques
Bjornstad Matthew
, Kosinski Tracy, Burlage Robert
Sep/Oct 2020
Pg. 434-438

Standards of Practice, Professional Judgment, and Scientific Evidence to Establish and Extend a Beyond-Use Date
Thomson Cassandra Marie
, Savji Taslim
Nov/Dec 2014
Pg. 456-460

Compounding Using Hazardous Drugs
Lau Kellie
Jul/Aug 2000
Pg. 261-263

PreScription: Factors Related to Drug Waste and Pharmacy Solutions
Allen Loyd V Jr
Jul/Aug 2018
Pg. 268

Drug-release Assessment of Compounded Topical Nifedipine and Diltiazem in Commonly Used Bases for Wound Healing
Teimouri Arezou
, Yeung Pollen, Agu Remigius U
Nov/Dec 2020
Pg. 501-508

Return to Top