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Sterile Basics of Compounding: Relationship Between Syringe Size and Dosing Accuracy

Author(s):  Kosinski Tracy M, Brown Michael C, Zavala Pedro J

Issue:  Jan/Feb 2018 - Volume 22, Number 1
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Abstract:  The purpose of this study was to investigate the accuracy and reproducibility of a 2-mL volume injection using a 3-mL and 10-mL syringe with pharmacy student compounders. An exercise was designed to assess each student’s accuracy in compounding a sterile preparation with the correct 4-mg strength using a 3-mL and 10-mL syringe. The average ondansetron dose when compounded with the 3-mL syringe was 4.03 mg (standard deviation ± 0.45 mg), which was not statistically significantly different than the intended 4-mg desired dose (P=0.497). The average ondansetron dose when compounded with the 10-mL syringe was 4.18 mg (standard deviation + 0.68 mg), which was statistically significantly different than the intended 4-mg desired dose (P=0.002). Additionally, there also was a statistically significant difference in the average ondansetron dose compounded using a 3-mL syringe (4.03 mg) and a 10-mL syringe (4.18 mg) (P=0.027). The accuracy and reproducibility of the 2-mL desired dose volume decreased as the compounding syringe size increased from 3 mL to 10 mL.

Related Keywords: Tracy M. Kosinski, PharmD, Michael C. Brown, PharmD, Pedro J. Zavala, MSP, PhD, syringe size, dosing accuracy, dose reproducibility, compounded sterile preparations, aseptic compounding, pharmacy students

Related Categories: PARENTERALS, STERILE PREPARATIONS, QUALITY CONTROL, PHARMACY EDUCATION, DOSAGE FORMS/DRUG CARRIERS

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