Abstract

Basics of Sterile Compounding: Intravenous Admixture Preparation, Part 11: Particulate Issues --- Silicone Oil in Vials, Cartridges, and Syringes

Author(s): Allen Loyd V Jr

Issue: Sep/Oct 2021 - Volume 25, Number 5

Page(s): 403-408

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Abstract

Silicone oil is commonly used for vial and cartridge stopper movement and in syringes to allow for smooth movement of the syringe plunger and removal of the contents. Particulates in injectables are a concern because the silicone oil often becomes a part of the injection solution, creating a potential for patient harm. Much has been written recently concerning silicone oil in syringes used in ophthalmology and the injections into the eye. There are methods and techniques presented here that can minimize the amount of silicone oil in the final injection that is ultimately administered to the patient. New syringe products are becoming available that are silicone oil free.

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