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Basics of Sterile Compounding: Intravenous Admixture Preparation, Part 11: Particulate Issues --- Silicone Oil in Vials, Cartridges, and Syringes

Author(s):  Allen Loyd V Jr

Issue:  Sep/Oct 2021 - Volume 25, Number 5
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Abstract:  Silicone oil is commonly used for vial and cartridge stopper movement and in syringes to allow for smooth movement of the syringe plunger and removal of the contents. Particulates in injectables are a concern because the silicone oil often becomes a part of the injection solution, creating a potential for patient harm. Much has been written recently concerning silicone oil in syringes used in ophthalmology and the injections into the eye. There are methods and techniques presented here that can minimize the amount of silicone oil in the final injection that is ultimately administered to the patient. New syringe products are becoming available that are silicone oil free.

Related Keywords: Loyd V. Allen, Jr, PhD, RPh, compounded sterile preparations, parenteral products, drug admixtures, particulates, silicone oil, rubber vial and cartridge stoppers, vial and cartridge stopper movement, syringe plunger movement, eye disorders, irritants, adverse reactions, solubility, siliconization, syringe manufacture innovations, particulate detection, minimizing particulates, ophthalmologic use of syringes

Related Categories: EXCIPIENTS, OPHTHALMICS, PACKAGING, PARENTERALS

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