Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats

Author(s):  Nani Marcel, Leone Andréia, Bom Vinícius Pedro, Buszinski Andrei Felipe, Oliveira de Souza Rebeca, Pinheiro Vanessa Alves, Danapoulos Panagiota, Swikidisa Rosita, Marquele-Oliveira Franciane, Cipriani Frade Marco Andrey, Berretta Andresa Aparecida, Nogueira Rodrigo José Lupatini

Issue:  Mar/Apr 2018 - Volume 22, Number 2
View All Articles in Issue

Page(s):  154-163

Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats Page 1
Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats Page 2
Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats Page 3
Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats Page 4
Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats Page 5
Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats Page 6
Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats Page 7
Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats Page 8
Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats Page 9
Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats Page 10

Download in electronic PDF format for $75

Abstract:  Several previous studies have demonstrated improved wound healing associated with natural-based formulations. Therefore, the purpose of this study was to assess the efficacy of a topical formulation containing both a Brazilian micronized propolis extract and a Peucedanum ostruthium leaf extract for the treatment of wounds created by surgical punch in rats. The study was conducted for 14 days and animals were treated as follows: gauze group (G), polyethylene glycol base ointment (Control), AlpaWash (an ointment containing a Brazilian micronized propolis extract and Peucedanum ostruthium leaf extract [Treatment]), and polysporin (one of the most commonly used topical antibiotic ointments, based on bacitracin zinc and polymyxin B sulfate [Reference Standard]). In general, the results demonstrated that ointments, due to occlusiveness and the ability to maintain moisture under the damaged area, offered improvements when compared to lesions without any treatment. Additionally, the presence of phenolic and flavonoid compounds, as well as antioxidants and antimicrobials, offered improved stimulation and could accelerate wound healing. The Control, Treatment, and Reference Standard groups were able to close the lesion, as measured by the wound healing rate determination and follow-up photographs. However, AlpaWash and Polysporin presented some additional benefits— anti-inflammatory activity, measured using myeloperoxidase and histological count, as well as fibroplasia and hydroxyproline production, suggesting that skin with a better quality could be formed following these two treatments. Therefore, based on the current concern of antibiotic overuse in wound healing, the emergence of multi-resistant organisms and the decrease in newer antibiotics, AlpaWash is considered a prominent formulation to be employed in wound-healing applications.

Related Keywords: Marcel Nani, MSc, Andréia Leone, PhD, Vinícius Pedro Bom, MSc, Andrei Felipe Buszinski, Rebeca Oliveira de Souza, MSc, PhD, Vanessa Alves Pinheiro, MSc, RPh, Panagiota Danopoulos, BSc, Rosita Swikidisa, MSc, Franciane Marquele-Oliveira, MSc, PhD, Marco Andrey Cipriani Frade, MSc, PhD, Andresa Aparecida Berretta, MSc, PhD, Rodrigo José Lupatini Nogueira, MSc, RPh, wound healing, topical preparations, micronized propolis extract, Peucedanum ostruthium leaf extract, natural products, Brazil, rats, ointments, phenolic compounds, flavonoid compounds, antioxidants, antimicrobial agents, anti-inflammatory agent, antibiotic overuse, skin infection, inflammation, skin ulcers, fibroplasia, hydroxyproline production

Related Categories: DERMATOLOGY, PEER-REVIEWED, WOUND CARE, DOSAGE FORMS/DRUG CARRIERS, INFECTIOUS DISEASE

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats
Nani Marcel
, Leone Andréia, Bom Vinícius Pedro, Buszinski Andrei Felipe, Oliveira de Souza Rebeca, Pinheiro Vanessa Alves, Danapoulos Panagiota, Swikidisa Rosita, Marquele-Oliveira Franciane, Cipriani Frade Marco Andrey, Berretta Andresa Aparecida, Nogueira Rodrigo José Lupatini
Mar/Apr 2018
Pg. 154-163

Options in Wound Care
Kincaid Michele R
Mar/Apr 2002
Pg. 92-95

Current Topical Treatments in Wound Healing - Part 1
Helmke Christopher D
Jul/Aug 2004
Pg. 269-274

Highlighting the Benefits of AlpaWash in Wound Care: Case Reports in Small Animals
Semighini Flavia
, Fornaciari Lais de Azevedo, Pinheiro Vanessa, Lupatini Rodrigo, Haiub Halema, Cull Erica, Sidhu Raman
Nov/Dec 2023
Pg. 454-460

Evaluation of the Antibacterial Activity of Green Propolis Extract and Meadowsweet Extract Against Staphylococcus aureus Bacteria: Importance in Would Care Compounding Preparations
Lupatini Nogueira Rodrigo José
, Danopoulos Panagiota, Swikidisa Rosita, Alves Pinheiro Vanessa
Jul/Aug 2016
Pg. 333-337

Drug-release Assessment of Compounded Topical Nifedipine and Diltiazem in Commonly Used Bases for Wound Healing
Teimouri Arezou
, Yeung Pollen, Agu Remigius U
Nov/Dec 2020
Pg. 501-508

A Compendium of Compounding Agents and Formulations, Part 6: Additional Preparations for Refractory Dermal-wound Healing
Riepl Mike
Nov/Dec 2022
Pg. 480-488

Compounding Pearls -- Wound Care: Diabetic Foot Ulcers, Part 2
Riepl Mike
Jul/Aug 2020
Pg. 278-281

Compounding Pearls -- Wound Care: Burn Healing, Part 2
Riepl Mike
Jul/Aug 2020
Pg. 282-285

Medicated Polyox Bandage for Skin Ulcers
Allen Loyd V Jr
Mar/Apr 2016
Pg. 146

Case Report: Wound Care of a Diabetic Foot Ulcer
Wynn Tom
Jul/Aug 2004
Pg. 265-267

Compounding Pearls -- Wound Care: Diabetic Foot Ulcers, Part 1
Riepl Mike
May/Jun 2020
Pg. 182-186

Compounding Pearls -- Wound Care: Drugs and Formulations for Dermal Healing, Part 2
Riepl Mike
Jul/Aug 2021
Pg. 282-287

Compounding Pearls--Wound Care: Drugs and Formulations for Dermal Healing, Part 3: The Roles of Nitric Oxide, Sildenafil, and Naltrexone
Riepl Mike
Sep/Oct 2021
Pg. 372-377

Compounding Pearls -- Wound Care: Burn Healing, Part 1
Riepl Mike
May/Jun 2020
Pg. 188-193

Compounding Pearls -- Wound Care: Drugs and Formulations for Dermal Healing
Riepl Mike
Mar/Apr 2021
Pg. 100-103

Ointment Vehicles, Featured Excipient:
Allen Loyd V Jr
Mar/Apr 2001
Pg. 145-146

Transdermal Nifedipine for Wound Healing: Case Reports
Torsiello Michael J
, Kopacki Matthew H
Sep/Oct 2000
Pg. 356

View Sample
Investigation of Filler Effects on the Compounding of Freeze-dried Orodispersible Tablets Containing Annona muricata Extract
Azman Syahiera Ezzah Noor
, Abd Razak Fashli Syafiq, Kamal Wan Hamirul Bahrin Wan, Zheng Gan Kok, Ming Long Chiau, Uddin ABM Helal, Sarker Zaidul Islam, Bin Liew Kai
Nov/Dec 2020
Pg. 509-514

Case Report: Diabetic Foot Ulcer Infection Treated with Topical Compounded Medications
Agbi Kelechi E
, Carvalho Maria, Phan Ha, Tuma Cristiane
Jan/Feb 2017
Pg. 22-27

Return to Top