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Biotin Regulates Colonization and Growth of Candida albicans in the Catheter Lumen During Nutrient Infusions

Author(s):  Ohara Hiroshi, Matsuzaki Tetsuya, Ochiai Tatsuya, Hayasaka Masataka

Issue:  Sep/Oct 2020 - Volume 24, Number 5
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Abstract:  Bacterial and fungal catheter-related bloodstream infections (CRBSI) cause high fever and blindness due to fungal endophthalmitis. Candidal CRBSI have a particularly high mortality rate and needs attention. In this study, we examined the effect of biotin on the colonization and growth of Candida albicans in the lumen of the catheter used for nutrient infusions. In the current study, nutrient infusion-1: commercially available peripheral parenteral nutrition (PPN) infusion solution with vitamin B1 (control), nutrient infusion-2: biotin added to the PPN infusion, nutrient infusion-3: water-soluble vitamins (B2, B6, B12, C, folic acid, nicotinamide, panthenol) except biotin added to the PPN infusion, and nutrient infusion-4: commercially available PPN infusion with all water soluble vitamins (B1, B2, B6, B12, C, folic acid, nicotinamide, biotin, panthenol) were used. Candida albicans suspension was injected into a Planecta infusion set, which was connected to one of the test solutions, and the infusions flow pass was blocked for approximately 30 minutes. Subsequently, the infusions were resumed, and the test solution was collected at 24 hours, 48 hours, and 72 hours to estimate the Candida albicans colony-forming units in each infusion. We demonstrated that nutrient infusion with biotin promoted colonization and proliferation in the catheter lumen, whereas those without biotin had no effect. These results suggest that biotin may accelerate the colonization and growth of Candida albicans in catheter lumen and using biotin-containing nutrient infusions may increase the risk of CRBSI.

Related Keywords: Hiroshi Ohara, PhD (Pharmacy), Tetsuya Matsuzaki, Bachelor (Pharmacy), Tatsuya Ochiai, Bachelor (Pharmacy), Masataka Hayasaka, PhD (Pharmacy), catheter-related bloodstream infections, CRBSI, bacterial infection, fungal infection, fungal endophthalmitis, fungus, Candida albicans, candidemia, peripheral vein catheters, catheter lumen colonization, nutrient infusions, parenteral nutrition solutions, peripheral parenteral nutrition, water-soluble vitamins


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