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Topical Cidofovir for Treatment of Resistant Viral Infections

Author(s):  McElhiney Linda F

Issue:  Sep/Oct 2006 - Dermatology
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Page(s):  324-328

Topical Cidofovir for Treatment of Resistant Viral Infections Page 1
Topical Cidofovir for Treatment of Resistant Viral Infections Page 2
Topical Cidofovir for Treatment of Resistant Viral Infections Page 3
Topical Cidofovir for Treatment of Resistant Viral Infections Page 4
Topical Cidofovir for Treatment of Resistant Viral Infections Page 5

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Abstract:  Cidofovir is a broad-spectrum antiviral agent with activity against several DNA viruses. An application to approve the use of topical cidofovir for acyclovir-resistant herpes virus infection was denied by the US Food and Drug Administration owing to the lack of phase III clinical trial data. The manufacturer stated that, as of 1997, no further controlled studies were planned or in progress to evaluate topical cidofovir in herpes simplex infections. It is unknown whether there are plans to conduct controlled studies of topical cidofovir for HPV or MVC infections. However, numerous case reports and published studies describe successful use of topical cidofovir to treat resistant and severe forms of viral infections such as molluscum contagiosum, condylomata acuminata, verruca vulgaris, herpes simplex virus infection, genital warts, and gingival infection with human papillomavirus. Because of the mutagenic properties of cidofovir, compounding the preparation is considered hazardous. Since most retail pharmacies

Related Keywords: Linda F. McElhiney, PharmD, RPh, cidofovir, antiviral agent, viral infections, topical preparations, antimicrobial resistance, molluscum contagiosum, condyloma acuminata, verruca vulgaris, genital warts, human papillomavirus, herpes simplex, CMV, cytomegalovirus retinitis, formulations


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