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Basics of Compounding: Compounding Nonsterile Preparations Using Cyclodextrins

Author(s):  Allen Loyd V Jr

Issue:  Mar/Apr 2022 - Volume 26, Number 2
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Abstract:  Complexation is a powerful therapeutic as well as a pharmaceutical tool. Many categories of medications contain complexes which aid in the stabilization and solubilization of the drugs they contain. Many also contain complexes which are useful for treating poisonings, increasing pharmacological activity, improving drug distribution, and enhancing bioavailability. Complexation is applied effectively during pharmaceutical formulation to solubilize and stabilize, as well as to decrease the taste or odor of drugs. This article discusses compounding with an emphasis on the cyclodextrins used as excipients in nonsterile preparations.

Related Keywords: Loyd V. Allen, Jr., PhD, RPh, complexation, complex, stabilization, stability, solubilization, solubility, bioavailability, organic molecular compounds, inclusion compounds, no-bond compounds, occlusion compounds, clathrates, channel inclusion complexes, layer inclusion complexes, monomolecular inclusion compounds, cyclodextrins, cyclic oligosaccharides, drug permeability, route of drug administration, drug delivery, protein products, formulations, parenteral agents

Related Categories: EXCIPIENTS, FORMULATIONS, STABILITIES, COMPATIBILITIES, STERILE PREPARATIONS, DOSAGE FORMS/DRUG CARRIERS

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