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Basics: Hollow-type Suppositories

Author(s):  Allen Loyd V Jr

Issue:  Jul/Aug 2022 - Volume 26, Number 4
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Page(s):  302-307

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Abstract:  Suppositories have not gained the level of acceptability, respect, and usage as most other dosage forms. Rectal administration is not often the first route of choice, but it becomes a good alternative when the oral route is inadvisable. Much work has been conducted in recent years on suppositories as a dosage form, as evidenced by the literature citations on suppository or suppositories. Although suppositories are not very popular as a mode of administering drugs, this dosage form will probably always have a place in medicine. Newer specialty suppository dosage forms have been developed to introduce drugs into the body, including the hollow-type suppository. Hollow-type suppositories have been investigated as a new dosage form that can be used for various purposes including but not limited to 1) enhancing the bioavailability of a drug, 2) slowing down or speeding up its onset of action, and 3) increasing or decreasing its duration of action. The flexibility of hollow-type suppositories may provide compounding pharmacists additional options for patients in the future. The purpose of this article is to provide a review of the characteristics and applications of hollow-type suppositories in both research and clinical situations.

Related Keywords: Loyd V. Allen, Jr., PhD, RPh, hollow-type suppository, suppositories, suppository bases, rectal administration, bioavailability, drug release rate, duration of drug action, transrectal administration, gentamicin, absorption, human chorionic gonadotropin, insulin, metoclopramide, morphine, cyclodextrins, propranolol, nifedipine, valproic acid


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