Enhanced Release of Diazepam from Hollow-Type Suppositories
Author(s): Kaewnopparat N, Kaewnopparat S, Rojanarat W, Ingkatawornwong S
Issue: Jul/Aug 2004 - Wound Care
View All Articles in Issue
Page(s): 310-312
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Abstract: The objective of this study was to develop a rapid-release
diazepam suppository. Four kinds of diazepam suppositories
were formulated: (1) a conventional suppository with
Witepsol H-15 as a base, (2) a conventional suppository
with mixed polyethylene glycols as a base, (3) a hollow-type
suppository with Witepsol H-15 as a base that contained
diazepam solution in its cavity and (4) a hollow-type suppository
with Witepsol H-15 as a base that contained diazepam
powder in its cavity. The result of the differential
scanning calorimetry thermograms indicated that diazepam
dissolved in Witepsol base had strong affinity to the
lipophilic base while diazepam dispersed in polyethylene
glycol base was still in the crystalline form. The release
study of prepared suppositories showed that the release of
diazepam from suppository 1 and suppository 4 was very
slow. The diazepam released from suppository 2 after
5 minutes was about 30%. The diazepam released from
suppository 3 after 5 minutes was about 85%, which was
significantly faster than that of the other three formulations
(1, 2 and 4). The hollow-type suppository that contained
diazepam solution was found to be the most effective
rapid-release formulation.
Related Keywords:
Diazepam, enhanced release, in hollow suppositories, Suppositories, diazepam compounding of
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