Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Clinical Management and Review of Sjogren's Syndrome

Author(s):  Dyke Shannon

Issue:  Sep/Oct 2000 - Compounding for Immune System Disorders
View All Articles in Issue

Page(s):  338

Clinical Management and Review of Sjogren's Syndrome Page 1

Download in electronic PDF format for $65

Abstract:  As many as 3% of Americans suffer from Sjogren’s syndrome, which affects populations worldwide and in all age groups. In this article, the author discusses the pathogenesis, symptoms and diagnosis of this disorder and treatment of ocular and oral symptoms (tear substitutes, antifungals, saliva substitutes, pilocarpine, anethole trithione, yohimbine and human interferon alpha). She also provides three formulas (Sodium Fluoride Gel [0.5% Fluoride] – 100 mL, Clotrimazole 10-mg Base A Troche – 24 Troches, and Saliva Substitute – 500 mL). She concludes that selection of treatment with the appropriate medications for patients with Sjogren’s syndrome depends on the severity of the symptoms, the clinical response to treatment and patient preference. For most patients, a regimen of oral pilocarpine (5 mg 4 times daily) plus the use of tear and saliva substitutes as needed is a beneficial combination. Less costly alternatives include stimulating saliva by chewing sugarless gum, sucking hard candy or using tear and saliva substitutes alone. Anethole trithione, yohimbine and natural human interferon alpha should be reserved for patients who cannot tolerate other treatments or who exhibit refractory disease.

Related Keywords: sjogren's, syndrome, autoimmune, saliva, salivary, mucous, lacrimal, secretions, xerophthalmia, xerostomia, dysphagia, tongue, lips, dryness, constipation, tear substitutes, artificial tears, antifungals, saliva substitutes, pilocarpine, anethole trithione, yohimbine, Human Interferon Alfa

Related Categories: DENTAL, EAR NOSE THROAT

Printer-Friendly Version

Related Articles from IJPC
(Click for Abstract / Details / Purchase)
Clinical Management and Review of Sjogren's Syndrome
Dyke Shannon
Sep/Oct 2000
Pg. 338

Kuntz Rachael
, Allen Michelle, Osburn Jennifer
May/Jun 2000
Pg. 176-177

Low-dose Pilocarpine Spray to Treat Xerostomia
Zur Eyal
Mar/Apr 2020
Pg. 104-108

Saliva Substitute for Dry Mouth/Throat
Allen Loyd V Jr
May/Jun 2000
Pg. 215

Saliva Substitute
Dyke Shannon
Sep/Oct 2000
Pg. 340

Artificial Tears for Dry Eyes
Allen Loyd V Jr
Sep/Oct 2000
Pg. 376

Saliva Tests, Part 1: Clinical Use, Elements of Testing, and Guidelines for Posttreatment Interpretation
Kells John
, Dollbaum Charles M
Jul/Aug 2009
Pg. 280-288

Saliva Tests, Part 2: Salivary Hormones, Hormone Replacement Pharmacokinetics, and the Importance of Timely Testing
Kells John
, Dollbaum Charles M
Sep/Oct 2009
Pg. 392-399

Measuring Testosterone Biomarkers in Serum and Saliva: Are They Accurate?
Tan Robert S
Nov/Dec 2004
Pg. 419-423

Surviving Cancer - How the Compounding Pharmacist Can Help
Maddox Suzan
Jul/Aug 2000
Pg. 257-260

Particle Measuring Systems - USP <797> Environmental Monitoring Solutions