Abstract

Quality Control Analytical Methods: Considerations in Compounding Peroral Solid Dosage Forms

Author(s): Vu Nicole

Issue: Mar/Apr 2007 - Diabetes

Page(s): 145-148

Download in electronic PDF format for $75

Abstract

Pharmacists who are engaged in drug compounding have specific guidelines and standards that are outlined in the United States Pharmacopeia–National Formulary. Of the many dosage forms that are available for the compounder, capsules and tablets (peroral solids) represent the most stable and convenient formulations for drug combinations. Dosage units must remain consistent, and the uniformity of dosage units should be demonstrable. Specific standards for the uniformity of dosage units are outlined in United States Pharmacopeia Chapter <905>, which was developed specifically for the pharmaceutical industry. The uniformity of dosage units can be demonstrated by either of two methods, Content Uniformity or Weight Variation. Weighing and blending activities are critical in compounding. Therefore, all efforts should be expended to prevent errors in weighing and other steps that could adversely affect the final preparation.

Related Keywords

Related Categories

Printer-Friendly Version

Related Articles from IJPC

Issue/Page View/Buy	Title/Author (Click for Abstract / Details / Purchase)
Mar/Apr 2007 Pg. 145-148	Quality Control Analytical Methods: Considerations in Compounding Peroral Solid Dosage Forms Author(s): Vu Nicole
Sep/Oct 1997 Pg. 349-351	Some Quality Control Tests on Chromium Picolinate in Solid Dosage Forms Author(s): Al-Achi Antoine, Greenwood Robert, Beasley Shawn
Jul/Aug 2013 Pg. 307-311	Quality Control Analytical Methods: End-preparation Assessments and Tests for Compounded Sterile Preparations Author(s): McElhiney Linda F
Jul/Aug 2008 Pg. 340-343	Quality-Control Analytical Methods: Homogeneity of Dosing Forms Author(s): Kupiec Thomas C, Vu Nicole, Branscum David
Jan/Feb 2004 Pg. 61-64	Quality-Control Analytical Methods: Selecting an Analytical Method Author(s): Allen Loyd V Jr
May/Jun 2004 Pg. 181-185	Compounding in the Pharmacy Curriculum: Beyond the Basics Author(s): Hinkle Amanda R, Newton Gail D
Sep/Oct 2009 Pg. 412-418	Quality-Control Analytical Methods: Designing a Quality-Control Potency Testing Program for a Compounding Pharmacy Author(s): Zolner William J
Jul/Aug 2015 Pg. 307-310	Quality Control Analytical Methods: Physical Quantitative Verification of Nonsterile Compounded Preparations: Individualized Dosage Units Author(s): Sidhu Raman
May/Jun 2004 Pg. 223-227	Quality-Control Analytical Methods: High-Performance Liquid Chromatography Author(s): Kupiec Thomas C
Jul/Aug 2004 Pg. 305-309	Quality-Control Analytical Methods: Gas Chromatography Author(s): Kupiec Thomas C
Jan/Feb 2005 Pg. 47-49	Quality-Control Analytical Methods: Microbial Testing Aspects of USP <797> for Compounded Sterile Preparations Author(s): Kupiec Thomas C
Mar/Apr 2005 Pg. 136-138	Quality-Control Analytical Methods: Chemical Testing Aspects of USP <797> for Compounded Sterile Preparations Author(s): Kupiec Thomas C
Sep/Oct 2016 Pg. 381-386	Quality Control Analytical Methods: Method Validation Author(s): Klang Mark G, Williams LaVonn A
Jul/Aug 2006 Pg. 281-284	Quality Control Analytical Methods: A Guide to Quality Control Testing for the Compounding Pharmacist Author(s): Zolner William J
Jan/Feb 2017 Pg. 47-56	Basics of Sterile Compounding: Biopharmaceutics of Injectable Dosage Forms Author(s): Akers Michael J
Nov/Dec 2022 Pg. 516-521	Formulation Development of Modafinil Sprinkle Dosage Form: Study on the Effect of Food on Dosage Author(s): Kumaravelrajan Rajagopal, Karthik B, Venkatasan Suba
May/Jun 1998 Pg. 240	Making Capsules Using a Solid Oral Dosage Form of a Different Strength Author(s): Glasnapp Andrew, Hua Yen-Tuyet
May/Jun 2014 Pg. 213-221	Quality Control Analytical Methods: Microbial Limit Tests for Nonsterile Pharmaceuticals, Part 1 Author(s): Vu Nicole, Lou Jessica R, Kupiec Thomas
Nov/Dec 2014 Pg. 479-484	Basics of Compounding: Unique and Special Characteristics of Sterile Dosage Forms Author(s): Akers Michael J
Nov/Dec 2007 Pg. 487-490	Quality-Control Analytical Methods: In-House Quality Control of Simple Compounds Author(s): Trusley Craig