Chemical Stability of Methylprednisolone Sodium Succinate After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes

Gupta, Vishnu D

Abstract

Chemical Stability of Methylprednisolone Sodium Succinate After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes

Author(s): Gupta Vishnu D

Issue: Mar/Apr 2001 - Compounding for Animals

View All Articles in Issue

Page(s): 148-150

Download in electronic PDF format for $75

Abstract

The chemical stability of methylprednisolone sodium succinate (10 mg/mL) in 0.9% sodium chloride injection has been studied at 25°C and 5°C in polypropylene syringes by means of a stability-indicating high-performance liquid chromatography assay method. The concentrations of the drug were directly related to the peak height, and the percent relative standard deviation based on five injections was 1.2. Benzyl alcohol, which is added as a preservative, did not interfere with the assay. Two products of decomposition separated from the intact drug. At 25°C, the loss of potency was less than 10% after 4 days of storage. At 5°C, the loss of potency was less than 5% when the injection was stored for 21 days. After 17 days of storage at 25°C, the pH value of the injection decreased from 7.2 to 6.5, and there was no change in the pH value when the injection was stored for 21 days at 5°C. The drug did not adsorb onto the syringes, and the physical appearance of the injection did not change.

Related Keywords

Related Categories

Printer-Friendly Version

Related Articles from IJPC

Issue/Page View/Buy	Title/Author (Click for Abstract / Details / Purchase)
Mar/Apr 2001 Pg. 148-150	Chemical Stability of Methylprednisolone Sodium Succinate After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes Author(s): Gupta Vishnu D
Jul/Aug 2003 Pg. 310-312	Chemical Stability of Cefuroxime Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D
Mar/Apr 2004 Pg. 153-155	Chemical Stability of Phenylephrine HCl After Reconstitution in 0.9% Sodium Chloride Injection for Infusion Author(s): Gupta Vishnu D
Mar/Apr 2003 Pg. 152-154	Chemical Stability of Cefazolin Sodium after Reconstituting in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D
Sep/Oct 2017 Pg. 426-429	Stability of Dalteparin 1,000 Unit/mL in 0.9% Sodium Chloride for Injection in Polypropylene Syringes Author(s): Kirkham Kylian, Munson Jessica M, McCluskey Susan V, Graner Kevin K
Mar/Apr 1997 Pg. 132-134	Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection Author(s): Zhang Yan-ping, Trissel Lawrence A
May/Jun 2004 Pg. 228-230	Physical and Chemical Stability of Trepostinil Sodium Injection Packaged in Plastic Syringe Pump Reservoirs. Author(s): Xu Quanyun A, Trissel Lawrence A, Pham Lien
Sep/Oct 2000 Pg. 396-397	Stability of Hydrocortisone Sodium Succinate After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D, Ling Jie
Jan/Feb 2001 Pg. 73-75	Stability of Ethacrynate Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D, Ling Jie
Jan/Feb 2001 Pg. 75-77	Stability of Acyclovir Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D, Ling Jie
May/Jun 2006 Pg. 234-236	Physical and Chemical Stability of Palonosetron Hydrochloride with Dacarbazine and with Methylprednisolone Sodium Succinate During Simulated Y-Site Administration Author(s): Trissel Lawrence A, Xu Quanyun A, Zhang Yanping
May/Jun 2001 Pg. 230-231	Stability of Piperacillin Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D, Ling Jie
Sep/Oct 2002 Pg. 395-397	Chemical Stability of Dexamethasone Sodium Phosphate After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes Author(s): Gupta Vishnu D
Jul/Aug 2021 Pg. 330-335	Stability of Dexmedetomidine in Polyvinyl Chloride Bags Containing 0.9% Sodium Chloride Intended for Subcutaneous Infusions Author(s): Wolfe Amanda, Zhang Jeremy, Lapenskie Julie, Downar James, Kanji Salmaan
May/Jun 2002 Pg. 234-236	Stability of Cefotaxime Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D
Nov/Dec 2000 Pg. 480-481	Stability of Nafcillin Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D, Ling Jie
May/Jun 1997 Pg. 208-209	Stability of Cefmetazole Sodium in 5% dextrose Injection and 0.9% Sodium Chloride Injection Author(s): Gupta Vishnu D, Maswoswe J, Bailey RE
Mar/Apr 2001 Pg. 151-152	Stability of Cefepime Hydrochloride After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Author(s): Gupta Vishnu D, Ling Jie
Jul/Aug 2001 Pg. 323-324	Compatibility and Stability of Potassium Chloride and Magnesium Sulfate in 0.9% Sodium Chloride Injection and 5% Dextrose Injection Solutions Author(s): Quay Irene, Tan Edward
Sep/Oct 2017 Pg. 436-439	Stability of Dexmedetomidine in 0.9% Sodium Chloride in Two Types of Intravenous Infusion Bags Author(s): Marquis Kathleen, Hohlfelder Benjamin, Szumita Paul M