Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Stability of Acyclovir Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use

Author(s):  Gupta Vishnu D, Ling Jie

Issue:  Jan/Feb 2001 - Compounding for Pediatric Patients
View All Articles in Issue

Page(s):  75-77

Stability of Acyclovir Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Page 1
Stability of Acyclovir Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Page 2
Stability of Acyclovir Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use Page 3

Download in electronic PDF format for $65

Abstract:  The stability of acyclovir sodium (10 mg/mL) in 0.9% sodium chloride injection has been studied at 25°C and 5°C in polypropylene syringes by means of a stability-indicating high-performance liquid chromatography (HPLC) assay method. The concentrations of the drug were directly related to peak heights, and the percent relative standard deviation (RSD) based on 5 injections was 1.0. At 25°C, there was no loss in potency after 30 days of storage, and at 5°C, the drug had begun to precipitate within 5 days. Therefore, the stability could not be investigated. The pH values of the injections were between 10.4 and 10.7. The drug was not adsorbed onto the syringes, and the physical appearance of the injection did not change.

Related Keywords: acyclovir, acyclovir injection, herpes virus, pediatric, stability, storage

Related Categories: INFUSION, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Stability of Acyclovir Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D
, Ling Jie
Jan/Feb 2001
Pg. 75-77

Acyclovir 50-mg/mL Injection
Allen Loyd V Jr
Sep/Oct 2013
Pg. 414

Acyclovir 200-mg/5-mL Oral Suspension (From the Injection)
Allen Loyd V Jr
Mar/Apr 2010
Pg. 151

Acyclovir 5% in Oral Adhesive Paste
Allen Loyd V Jr
Mar/Apr 2010
Pg. 150

Acyclovir 20-mg/mL Oral Suspension
Allen Loyd V Jr
Jul/Aug 2013
Pg. 326

Acyclovir 200-mg Capsules
Allen Loyd V Jr
Jul/Aug 2013
Pg. 327

Acyclovir with Lidocaine and Sunscreen Stick ( Herpes Ointment )
Nelson James L
Jul/Aug 1998
Pg. 278

Acyclovir with Benzocaine Lip Balm
Allen Loyd V Jr
Jul/Aug 2010
Pg. 332

Acyclovir 5% Lip Balm with Dioxybenzone and Oxybenzone
Allen Loyd V Jr
Jul/Aug 2010
Pg. 333

Basics of Compounding for Cold Sores or Fever Blisters
Allen Loyd V Jr
May/Jun 2004
Pg. 206-209

Particle Measuring Systems - USP <797> Environmental Monitoring Solutions