Stability of Acyclovir Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use

Gupta, Vishnu D; Ling, Jie

Abstract

Stability of Acyclovir Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use

Author(s): Gupta Vishnu D, Ling Jie

Issue: Jan/Feb 2001 - Compounding for Pediatric Patients

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Page(s): 75-77

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Abstract

The stability of acyclovir sodium (10 mg/mL) in 0.9% sodium chloride injection has been studied at 25°C and 5°C in polypropylene syringes by means of a stability-indicating high-performance liquid chromatography (HPLC) assay method. The concentrations of the drug were directly related to peak heights, and the percent relative standard deviation (RSD) based on 5 injections was 1.0. At 25°C, there was no loss in potency after 30 days of storage, and at 5°C, the drug had begun to precipitate within 5 days. Therefore, the stability could not be investigated. The pH values of the injections were between 10.4 and 10.7. The drug was not adsorbed onto the syringes, and the physical appearance of the injection did not change.

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