Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Chemical Stability of Methadone Concentrate and Powder Diluted in Orange-Flavored Drink

Author(s):  Donnelly Ronald F

Issue:  Nov/Dec 2004 - Endotoxin
View All Articles in Issue

Page(s):  489-491

Chemical Stability of Methadone Concentrate and Powder Diluted in Orange-Flavored Drink Page 1
Chemical Stability of Methadone Concentrate and Powder Diluted in Orange-Flavored Drink Page 2
Chemical Stability of Methadone Concentrate and Powder Diluted in Orange-Flavored Drink Page 3

Download in electronic PDF format for $75

Abstract:  Methadone, traditionally used in the treatment of heroin addiction, recently has been used to treat severe pain. The chemical stability of methadone has been studied in concentrations up to 1.5 mg/mL only. Commercial methadone concentrate (10 mg/mL) and methadone powder was diluted to 5 mg/mL with orange-flavored Tang drink. Sodium benzoate was added to the solutions prepared from powder. Bottles were stored at either room temperature (22 degrees C) or under refrigeration (6 degrees C) for 91 days. Samples were analyzed in duplicate by a stability-indicating high-performance liquid chromatographic assay, and clarity and pH were also monitored. One additional solution was prepared from powder but no preservative was added; this solution was monitored for presence of bacterial growth at room temperature only. Solutions prepared from the concentrate and powder with preservative showed no signs of change in clarity on storage. The solution made from powder only developed turbidity after 21 days, which suggested bacterial growth. There was no significant change in pH over the course of the study. After 91 days of storage at either room temperature or under refrigeration, there was no change in concentration for solutions prepared from concentrate or powder with preservative. Methadone solutions prepared from the commercial concentrate or powder with sodium benzoate are stable for 91 days at room temperature or under refrigeration. Solutions prepared from the powder but not containing a preservative showed signs of bacterial growth after 21 days at room temperature.

Related Keywords: Ron Donnelly, MSc (Chem), BSc (Pharm), methadone, pain relief, pain control, preservative

Related Categories: EXCIPIENTS, PAIN MANAGEMENT, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Chemical Stability of Methadone Concentrate and Powder Diluted in Orange-Flavored Drink
Donnelly Ronald F
Nov/Dec 2004
Pg. 489-491

PostScription: Treatment of Chronic Pain with Methadone or Levorphanol
McNulty Jack P
Mar/Apr 2006
Pg. 159-160

Featured Excipient: Flavor Enhancing Agents
Allen Loyd V Jr
Jan/Feb 2003
Pg. 48-50

Compounded Analgesic Therapy for Disorders of Movement: Arthritis, Neuropathic Pain, and Postpolio Syndrome
Brown Scott
, Erickson Brian, Muller George, Bryant-Snure Susan J, Mestayer Richard F III
May/Jun 2010
Pg. 182-192

Topical Medications for Orofacial Neuropathic Pain
Bramwell Bethany L
May/Jun 2010
Pg. 200-203

Chemical Stability of Fentanyl in Polypropylene Syringes and Polyvinylchloride Bags
Donnelly Ronald F
Nov/Dec 2005
Pg. 482-483

Oral Methadone for Management of Regional Sympathetic Dystrophy Syndrome: A Case Revisited
Vail Jane
May/Jun 2007
Pg. 187-192

Compounded Pain Formulations: What is the Evidence?
Asbill Scott
, Sweitzer Sarah M, Spigener Shuler, Romero-Sandoval Alfonso
Jul/Aug 2014
Pg. 278-286

Levorphanol, Methadone, and the Management of Intractable Chronic Pain: An Interview with Kerry Schmidt, BA, MBA; Jack P. McNulty, MD, FACP; and George B. Muller, RPh
Vail Jane
Jan/Feb 2006
Pg. 9-11

Stability of Venlafaxine Immediate-Release Suspensions
Donnelly Ronald F
, Wong Keith, Goddard Rob, Johanson Christel
Jan/Feb 2011
Pg. 81-84

Efficacy and Clinical Value of Commonly Used Ingredients in Pain Management Compounds: A Literature Review
Beshay Sarah M
, Rivera Gerard, Balthasar Jan, Florea Naomi
Jul/Aug 2015
Pg. 295-300

Case Reports: Compounding to Relieve Arthritis Pain
Marshall Robert
, Vidaurri Vincent A, Boomsma Diane, Buchta Anthony J, Vail Jane
Nov/Dec 2008
Pg. 498-504

Update on Managing Neuropathic Pain
McNulty Jack P
, Muller George
May/Jun 2009
Pg. 182-190

Topical Pain Relief: Assessment of Patient Satisfaction with a Novel Compound Containing at Least Ketoprofen
Zugerman Jessie Jean M
, Reed Thomas C
Nov/Dec 2007
Pg. 514-519

Topical Ketamine: A Review of the History, Mechanisms, Uses, Safety, and Future
Rabi Joseph
Mar/Apr 2016
Pg. 107-113

Stability Studies of Fludrocortisone Acetate Capsules and Fludrocortisone Acetate Titrated Powders (Powder Triturates)
Brandin Thibaut
, Wasilewski Maya, Panuccio Camille, Bouguergour Cyrielle, Primas Nicolas, Lamy Edouard, Jean Christophe, Bertault-Peres Pierre, Rathelot Pascal, Curti Christophe, Vanelle Patrice
Mar/Apr 2022
Pg. 150-154

Stability of Fentanyl Citrate in Polyolefin Bags
Donnelly Ronald F
Nov/Dec 2016
Pg. 514-516

Levorphanol for the Treatment of Severe Chronic Pain
McNulty Jack P
May/Jun 2007
Pg. 202-211

Topical Treatment of Neuropathic Pain
Vadaurri Vince
May/Jun 2008
Pg. 182-190

Flavors and Flavoring
Allen Loyd V Jr
Mar/Apr 1997
Pg. 90-92

Return to Top