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Basics of Compounding for Pediatric Patients: Commonly Prescribed Oral Liquid Formulations, Vehicles, and Stock Solutions

Author(s):  Fonseca Simonne C

Issue:  Nov/Dec 2005 - Pediatrics
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Abstract:  Just a glance at a pharmacy shelf reveals the small number of commercially available medications in oral liquid form. Mainly for stability reasons, but also because of economic motives, pharmaceutical companies tend to manufacture drugs in solid oral forms rather than liquid oral forms. Furthermore, 80% of prescription drugs approved by the US Food and Drug Administration for human use are not approved for use in children. Extemporaneous pharmacy compounding fills this gap and provides effective, personalized treatment for children in need of a medication that may not be commercially available. This review focuses on practical, frequently used formulations for compounding oral liquid forms. The compounding pharmacist should perform quality control tests on the final preparation according to pharmacy standards for extemporaneous oral liquid preparations.

Related Keywords: Simonne Fonseca, RPh, children, formulations, liquid preparations, vehicles, stock solutions, flavoring agents, sweetening agents

Related Categories: EXCIPIENTS, FORMULATIONS, PEDIATRICS, DOSAGE FORMS/DRUG CARRIERS

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