Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of all issues and individual articles published by the Journal since 1997.

Stability of Commercially Available Grape and Compounded Cherry Oral Vancomycin Preparations Stored in Syringes and Cups

Author(s):  Kirk Loren, Lewis Paul, Luu Yao, Brown Stacy

Issue:  Mar/Apr 2016 - Volume 20, Number 2
View All Articles in Issue

Page(s):  159-163

Stability of Commercially Available Grape and Compounded Cherry Oral Vancomycin Preparations Stored in Syringes and Cups Page 1
Stability of Commercially Available Grape and Compounded Cherry Oral Vancomycin Preparations Stored in Syringes and Cups Page 2
Stability of Commercially Available Grape and Compounded Cherry Oral Vancomycin Preparations Stored in Syringes and Cups Page 3
Stability of Commercially Available Grape and Compounded Cherry Oral Vancomycin Preparations Stored in Syringes and Cups Page 4
Stability of Commercially Available Grape and Compounded Cherry Oral Vancomycin Preparations Stored in Syringes and Cups Page 5

Download in electronic PDF format for $75

Abstract:  The purpose of this study was to evaluate the stability of two preparations of vancomycin oral solution in two different storage containers, capped amber oral dosing syringes and heat-sealed oral-dosing cups, stored under refrigerated conditions. Commercially available grape-flavored vancomycin oral preparation and compounded vancomycin for intravenous use in cherry syrup oral preparation were divided into 5-mL aliquots into heat-sealed plastic dosing cups and capped oral-dosing syringes. All samples were stored under refrigeration (2°C to 8°C) and evaluated at days 0, 3, 7, 14, 30, 60, and 90. For each evaluation, samples were visually inspected and analyzed for potency using a stability-indicating high-performance liquid chromatographic method with ultraviolet detection. Over the study period, at least 90% of the initial concentrations for the preparation and the product in both storage containers were retained at 60 days. The commercially available oral vancomycin further demonstrated stability within 90% out to 90 days in the syringe and the unit-dose cups. Visual inspection revealed no changes in the grape-flavored vancomycin oral preparation, but a detectable red-dye precipitate could be seen in the crevices of the dosing cups from the vancomycin in cherry syrup oral preparation after 60 days. Commercially available grape-flavored vancomycin oral preparation was stable up to 90 days, and compounded vancomycin for intravenous use in cherry syrup oral preparation maintained stability for 60 days when dispensed in capped amber polypropylene oral-dosing syringes and heat-sealed plastic dosing cups when stored at refrigerated conditions.

Related Keywords: vancomycin, bacterial infection, antibiotic, oral solutions, antimicrobial agent, liquid dosage forms, flavored liquid vehicle, flavorings, storage containers, stability, repackaging

Related Categories: EXCIPIENTS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, DOSAGE FORMS/DRUG CARRIERS, INFECTIOUS DISEASE, STORAGE

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Stability of Commercially Available Grape and Compounded Cherry Oral Vancomycin Preparations Stored in Syringes and Cups
Kirk Loren
, Lewis Paul, Luu Yao, Brown Stacy
Mar/Apr 2016
Pg. 159-163

Chemical Stability of Perphenazine in Two Commercially Available Vehicles for Oral Liquid Dosage Forms
Gupta Vishnu D
Jul/Aug 2008
Pg. 372-374

Comparison of Rheological and Sedimentation Behavior of Commercially Available Suspending Vehicles for Oral Pharmaceutical Preparations
Visser J Carolina
, ten Seldam Inge E J, van der Linden Isabella J, Hinrichs Wouter L J, Veenendaal Reinier F H, Dijkers Eli C F, Woerdenbag Herman J
May/Jun 2018
Pg. 247-251

Compatibility of Flavoring Agents in Compounding Extemporaneous Omeprazole Oral Liquid
Chuong Monica
, Taglieri Catherine A, Huang Szu Yu, Sariol Anthony, Kitigawa Reina, Barman Koushik, Mistry Amee, Harris Donna L, Kerr Stephen G
Nov/Dec 2019
Pg. 504-510

Oral Liquid Vehicles, Featured Excipient:
Allen Loyd V Jr
Jan/Feb 2001
Pg. 65-67

Flavors and Flavoring
Allen Loyd V Jr
Mar/Apr 1997
Pg. 90-92

Comparative Stability Study of Unit-dose Vancomycin Hydrochloride Oral Solutions in Plastic Capped Oral Syringes and Plastic Sealed Dosage Cups
Brown Stacy
, Lewis Paul
May/Jun 2020
Pg. 234-237

Stability of Oral Liquid Dosage Forms of Glycopyrrolate Prepared with the Use of Powder
Gupta Vishnu D
Sep/Oct 2003
Pg. 386-388

Long-term Stability of Vancomycin Hydrochloride in Oral Solution: The Brand Name Versus a Generic Product
Huvelle Sophie
, Godet Marie, Hecq Jean-Daniel, Gillet Patricia, Jamart Jacques, Galanti Laurence M
Jul/Aug 2016
Pg. 347-350

Compatibility and Stability of Cefotaxine, Vancomycin, and Ciprofloxacin in Antibiotic Lock Solutions Containing Heparin
Baker Daniel S
, Waldrop Bruce, Arnold John
Jul/Aug 2010
Pg. 346-349

Featured Excipient: Flavor Enhancing Agents
Allen Loyd V Jr
Jan/Feb 2003
Pg. 48-50

Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents
Gupta Vishnu D
May/Jun 2007
Pg. 259-261

Chemical Stability of Isoniazid in an Oral Liquid Dosage Form
Gupta Vishnu D
, Sood Arun
Mar/Apr 2005
Pg. 165-166

Basics of Compounding for Pediatric Patients: Commonly Prescribed Oral Liquid Formulations, Vehicles, and Stock Solutions
Fonseca Simonne C
Nov/Dec 2005
Pg. 456-461

Physicochemical and Microbiological Stability of Vancomycin 10-mg/mL Intravitreal Syringes
Bartoll Aaron Puplà
, Bellés Medall Maria Dolores, Peñarrocha Josep Edo, Escrig Laura Solaz, Clemente Ruben Eguren, Azuara Julia Bodega, Piqueres Raul Ferrando
Jul/Aug 2022
Pg. 330-335

Pediatric Compounding: Coloring Outside the Lines
Preckshot John
Jan/Feb 2001
Pg. 6-8

Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms
Gupta Vishnu D
Sep/Oct 2009
Pg. 445-446

Three Fortified Ophthalmic Solutions: Amikacin 5% Ophthalmic Solution; Ceftazidime 5% Ophthalmic Solution; Vancomycin 5% Ophthalmic Solution
Allen Loyd V Jr
Sep/Oct 2010
Pg. 421

Preparation and Stability Evaluation of Extemporaneous Oral Suspension of Valsartan Using Commercially Available Tablets
Zaid Abdel Naser
, Assali Mohyeddin, Qaddomi Aiman, Ghanem Mashhour, Zaaror Yara Abu
Mar/Apr 2014
Pg. 169-174

Stability of Levothyroxine, Doxycycline, Hydrocortisone, and Pravastatin in Liquid Dosage Forms Stored at Two Temperatures
Nahata Milap C
Sep/Oct 2015
Pg. 428-431

Return to Top