Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Chemical Stability of Perphenazine in Oral Liquid Dosage Forms

Author(s):  Gupta Vishnu D

Issue:  Nov/Dec 2005 - Pediatrics
View All Articles in Issue

Page(s):  484-486

Chemical Stability of Perphenazine in Oral Liquid Dosage Forms Page 1
Chemical Stability of Perphenazine in Oral Liquid Dosage Forms Page 2
Chemical Stability of Perphenazine in Oral Liquid Dosage Forms Page 3

Download in electronic PDF format for $65

Abstract:  The stability of perphenazine in oral liquid dosage forms was studied by means of a stability-indicating high-performance liquid chromatography assay method that was developed in our laboratory. There was a direct relationship between the peak heights and the concentrations, with an r value of 0.998. The percent relative standard deviation based on five injections was 0.6. The products of decomposition and excipients present in the dosage forms did not interfere with the developed assay method. The dosage forms were stable for only 30 days when stored in amber-colored glass bottles at room temperature. The pH value of the mixtures remained constant at 3.7 after 90 days of storage, and the physical appearance of the mixtures did not change. The recommended beyond-use date of 30 days is recommended for this product.

Related Keywords: Vishnu D. Gupta, PhD, perphenazine, anticholinergic agent, antiemetic agent, sedative, extrapyramidal effects, stability, liquid preparations

Related Categories: MENTAL HEALTH, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, DOSAGE FORMS/DRUG CARRIERS, NEUROLOGY

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Wetting and/or Solubilizing Agents, Featured Excipient:
Allen Loyd V Jr
Jul/Aug 2001
Pg. 310-312

Chemical Stability of Perphenazine in Oral Liquid Dosage Forms
Gupta Vishnu D
Nov/Dec 2005
Pg. 484-486

Chemical Stability of Perphenazine in Two Commercially Available Vehicles for Oral Liquid Dosage Forms
Gupta Vishnu D
Jul/Aug 2008
Pg. 372-374

Compounding for the Effects of Weapons of Mass Destruction
Sammarco Domenic A
Jan/Feb 2003
Pg. 10-15

View Sample
Chemical Stability of Hydrocortisone in an Oral Liquid Dosage Form without Suspending Agents
Gupta Vishnu D
May/Jun 2007
Pg. 259-261

Chemical Stability of Brompheniramine Maleate in an Oral Liquid Dosage Form
Gupta Vishnu D
, Gupta Vikas S
Jan/Feb 2011
Pg. 78-80

Basics of Sterile Compounding: Excipients Used in Injections
Akers Michael J
Jul/Aug 2017
Pg. 301-308

Compatibility of Flavoring Agents in Compounding Extemporaneous Omeprazole Oral Liquid
Chuong Monica
, Taglieri Catherine A, Huang Szu Yu, Sariol Anthony, Kitigawa Reina, Barman Koushik, Mistry Amee, Harris Donna L, Kerr Stephen G
Nov/Dec 2019
Pg. 504-510

Chemical Stability of Isoniazid in an Oral Liquid Dosage Form
Gupta Vishnu D
, Sood Arun
Mar/Apr 2005
Pg. 165-166

Chemical Stability of Amitriptyline Hydrochloride in Oral Liquid Dosage Forms
Gupta Vishnu D
Sep/Oct 2009
Pg. 445-446