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Quality-Control Analytical Methods: Using Purified Water for Reconstitutions

Author(s):  Biller Jeremy

Issue:  Jul/Aug 2011 - Volume 15, Number 4
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Abstract:  Using the correct water to reconstitute compounded medications is essential to ensuring the safety and effectiveness of those preparations. Tap water is suitable for drinking but contains impurities and chemicals that render it inappropriate for use in medications and enable the growth of bacteria and mold that contaminate compounds. Compounders who are unwilling to purchase and store bottled water may consider installing a water purification system in their pharmacy. On-site units are convenient and easy to use, ensure a sufficient and ready supply of purified water for compounding, offer automated dispensing that streamlines the preparation of medications and reduces the likelihood of error, and may save cost. This article addresses the use of purified water in reconstitutions and presents factors for consideration by compounding pharmacists who are contemplating the purchase of an in-house water purification unit. An accompanying table lists features of water purification systems that are appropriate for use in a compounding pharmacy.

Related Keywords: Jeremy Biller, water purification, reconstituted compounds, quality control

Related Categories: EXCIPIENTS, SUPPORT, TECHNOLOGY, QUALITY CONTROL, UNITED STATES PHARMACOPEIA CONVENTIONS

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