Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Evaluation of Containment Ventilated Enclosure Performance in Absence of Negative Pressure Containment Secondary Engineering Control

Author(s):  Hutson Chad, Day A J

Issue:  Nov/Dec 2019 - Volume 23, Number 6
View All Articles in Issue

Abstract:  The purpose of this study was to evaluate the efficacy of a containment ventilated enclosure on preventing powder exposure to surrounding areas during a high-particle generating compounding procedure in absence of a negative pressure compounding secondary engineering control. Air samples were collected under actual compounding conditions to assess compounder and room exposure to estradiol powder. Samples were collected from several locations. The entire compounding process took place in a containment ventilated enclosure after assessing performance characteristics via velocity and smoke sampling. The particle generating compounding process consisted of weighing, multiple transfers, trituration, and capsule filling. Compounding procedures were performed by three different compounders. The laboratory detection limit for estradiol was determined, and collection parameters were targeted to ensure adequate samples were obtained to prevent false negative results. Sampling time for each compounder ranged from 24 minutes to 38 minutes. All samples collected during compounding procedures showed less than detectable amounts of estradiol. Observation of the compounding procedure showed notable potential particle generation during the compounding procedure, including spills and vigorous jostling of compounding equipment prior to encapsulation. Despite a significant potential for particulate generation inside the containment ventilated enclosure, no estradiol was detected outside of the enclosure. These findings suggest that powder chemical exposure to the compounder is minimal when using a properly certified containment ventilated enclosure. The findings also show a lack of exposure of the room to aerosolized estradiol even when using a neutral containment secondary engineering control.

Related Keywords: Chad Hutson, PharmD, A.J. Day, PharmD, hazardous ingredients, hazardous drugs, personnel protection, United States Pharmacopeia <800> Hazardous Drugs--Handling in Healthcare Settings, containment ventilated enclosure, CVE, C-SEC, compounding particle generation, airborne particles, estradiol powder, primary engineering control, workplace contamination, occupational exposure, aerosols, vapor contamination, particulates, vapor pressures, National Institute for Occupational Safety and Health, NIOSH, air sampling, HEPA-filtered air, high particle aerosol generation, negative pressure secondary engineering control, external ventilation


Printer-Friendly Version

Download in electronic PDF format for $55

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Evaluation of Containment Ventilated Enclosure Performance in Absence of Negative Pressure Containment Secondary Engineering Control Hutson Chad, Day A J Nov/Dec 2019 511-518 Buy
Quality Control: Personal Protective Equipment for Use When Handling Hazardous Drugs Dillon L R Jan/Feb 2020 30-36 Buy
Certification of Powder-containment Hoods for Nonsterile Compounding Mulder Kyle, Dozzi Raphael Sep/Oct 2018 369-384 Buy
Compounding Enclosures: Ensuring Safety During the Preparation of Sterile and Nonsterile Formulations Ashe Krystina, Baskett Dustin Sep/Oct 2018 387-398 Buy
How to Develop and Maintain a Hazardous Drug List Dillon L Rad May/Jun 2019 182-186 Buy
Performing a United States Pharmacopeia Chapter <800> Compliant Assessment of Risk Cabaleiro Joe Jan/Feb 2020 21-27 Buy
Preparing Nonsterile and Sterile Hazardous Compounds in an Institutional Setting McElhiney Linda F Jul/Aug 2009 300-310 Buy
Basics of Compounding for Hazardous Drugs, Part 4: Developing the Hazardous Drugs List and Containment Workstations Allen Loyd V Jr Mar/Apr 2007 149-151 Buy
PreScription: Permissible Exposure Limits and United States Pharmacopeia Chapter <800> Allen Loyd V Jr Sep/Oct 2021 356 Buy
Hazardous Drug Enteral Device: A Closed System Device for Crushing and Dispersing Hazardous Drug Tablets for Enteral Administration Lopez C Vidal, Rios GL Quito Sep/Oct 2022 358-362 Buy