Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Rapid Pharmacokinetic Evaluation of Topical Drug Formulations

Author(s):  Garzouzi Victoria L, Reifenrath William G

Issue:  Jul/Aug 1999 - Compounding Parenteral Products
View All Articles in Issue

Page(s):  321-324

Rapid Pharmacokinetic Evaluation of Topical Drug Formulations Page 1
Rapid Pharmacokinetic Evaluation of Topical Drug Formulations Page 2
Rapid Pharmacokinetic Evaluation of Topical Drug Formulations Page 3
Rapid Pharmacokinetic Evaluation of Topical Drug Formulations Page 4

Download in electronic PDF format for $75

Abstract:  A new in vitro test system was developed to efficiently determine the effect of formulation on topical drug delivery.

Sheets of viable, excised pig skin were sandwiched between two standard 24-well plates. The lower wells contained receptor fluid and a magnetic stirrer. The upper wells were opened to the atmosphere for formulation application. Using 14Csalicylic acid as a model compound, eight different formulations were evaluated representing hydrophilic and lipophilic solutions, a suspension and o/w and w/o emulsions. Formulations were applied to the skin surface in six different wells on three sets of plates. Twenty-four hours after application, excess drug was wiped from the skin surface and assayed for radiolabel. The stratum corneum was removed by tape stripping and radiolabel determined by electronic autoradiography. Radiolabel contained in the remaining epidermis, dermis and receptor fluid was also determined.

Statistical analysis (ANOVA, Student-Newman-Keuls multiple- range test, p=0.05) of radiolabel penetrating into the dermis and receptor fluid revealed the following order of formulations: ethanol = aqueous surfactant < o/w emulsion = w/o emulsion

Related Keywords: skin, suspensions, topical drug delivery

Related Categories: DERMATOLOGY, PAIN MANAGEMENT, PEER-REVIEWED, SPORTS MEDICINE, WOUND CARE

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Rapid Pharmacokinetic Evaluation of Topical Drug Formulations
Garzouzi Victoria L
, Reifenrath William G
Jul/Aug 1999
Pg. 321-324

Current Topical Treatments in Wound Healing - Part 1
Helmke Christopher D
Jul/Aug 2004
Pg. 269-274

Novel Approaches to Topical Psoriasis Therapy
Koyama Gregory
, Liu Jenny, Scaffidi Alyse, Khazraee Maryam, Epstein Benjamin
Sep/Oct 2015
Pg. 357-365

Formulation and In Vitro Evaluation of a Ramipril Entrapped in a Microsponge-based Drug-delivery System
Taghi Hassanien Sagban
, Abdulbaqi Mustafa R, Samein Laith Hamza, Rahmani Maha H Philip
Jul/Aug 2023
Pg. 340-346

Transdermals: The Skin as Part of a Drug Delivery System
Allen Loyd V Jr
Jul/Aug 2011
Pg. 308-315

In Vitro Skin Penetration and Skin Content of Progesterone from Various Topical Formulations
Heustess Allie
, Asbill Scott, Eagerton David, Arnold John
Nov/Dec 2014
Pg. 512-515

Personalized Medicine and Customized Drug Delivery Systems: The New Trend of Drug Delivery and Disease Management
Soni Abhishek
, Gowthamarajan Kuppusamy, Radhakrishnan Arun
Mar/Apr 2018
Pg. 108-121

Enhancement of Skin Penetration of Nonsteroidal Anti-Inflammatory Drugs from Extemporaneously Compounded Topical-Gel Formulations
Goodwin Donald A
, Fuhram L Clifton
Nov/Dec 1999
Pg. 496-500

Skin Permeation and Antinociception of Compounded Topical Cyclobenzaprine Hydrochloride Formulations
Bryson Evan
, Hartman Rachel, Arnold John, Gorman Greg, Sweitzer Sarah.Asbill Scott
Mar/Apr 2015
Pg. 161-166

Drug-release Assessment of Compounded Topical Nifedipine and Diltiazem in Commonly Used Bases for Wound Healing
Teimouri Arezou
, Yeung Pollen, Agu Remigius U
Nov/Dec 2020
Pg. 501-508

Quality Control: Personal Protective Equipment for Use When Handling Hazardous Drugs
Dillon L R
Jan/Feb 2020
Pg. 30-36

Skin Penetration and Antinociception of Topical Gabapentin Formulations
Bryson Evan
, Asbill Scott, Sweitzer Sarah
Nov/Dec 2014
Pg. 504-511

PreScription: 2017 Pharmacy Compounding Issues: The U.S. Food and Drug Administration, Harzardous Drugs, and Wasted Drugs
Allen Loyd V Jr
Sep/Oct 2017
Pg. 356

In Vitro Permeability, Irritability, and Release Evaluation of Commonly Used Topical Diclofenac Gel Preparations (1%, 5%, and 10%)
Kohan Hamed Gilzad
, Baker David M, Sani Shabnam, Bielecki-Wilken Kathleen A, Ramirez Alfonso
Mar/Apr 2021
Pg. 146-155

Pluronic Lecithin Organogel for Local Delivery of Anti-Inflammatory Drugs
Frankum James
, Ramsay Dale, Das Nandita G, Das Sudip K
Mar/Apr 2004
Pg. 101-105

U.S. Food and Drug Administration "Evaluation Criteria" for Difficult to Compound Drugs
Allen Loyd V Jr
Nov/Dec 2015
Pg. 487-488

NASEM Report on Compounded Topical Pain Creams
Allen Loyd V Jr
Nov/Dec 2020
Pg. 446-448

Compounding Pearls -- Wound Care: Drugs and Formulations for Dermal Healing
Riepl Mike
Mar/Apr 2021
Pg. 100-103

Basics of Sterile Compounding: Biopharmaceutics of Injectable Dosage Forms
Akers Michael J
Jan/Feb 2017
Pg. 47-56

Topical Use of Sodium Cromoglicate (Cromolyn Sodium) to Treat Atopic Dermatitis and Other Skin Allergies
Zur Eyal
Sep/Oct 2012
Pg. 386-393

Return to Top