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Transdermals: The Skin as Part of a Drug Delivery System

Author(s):  Allen Loyd V Jr

Issue:  Jul/Aug 2011 - Volume 15, Number 4
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Abstract:  Transdermal delivery of drugs is effective and widely used to treat many different conditions. Transdermal drug delivery can be “individualized” for each patient by changing the drugs used, their concentrations, and the formulation. This type of drug delivery is routinely used for delivery of hormones, pain medications, nonsteroidal anti-inflammatory drugs, antinauseant medications, and many, many others. This article discusses the mechanism, the factors involved, the different penetration enhancers, how to control the rate of delivery, and provides some of the advantages and disadvantages of transdermal drug delivery.

Related Keywords: Loyd V. Allen, Jr, PhD, RPh, transdermal administration, topical preparations, drug delivery, percutaneous drug absorption, formulations, scopolamine hydrobromide, promethazine, hydrogels, excipients, skin layers, anxiolytic agents, antinausea, antiemetic, nausea and vomiting, motion sickness, dexamethasone, lorazepam, haloperidol, diphenhydramine hydrochloride, metoclopramide hydrochloride, buspirone hydrochloride, hormone replacement therapy, progesterone, estradiol, testosterone, ketoprofen, piroxicam, nonsteroidal anti-inflammatory drugs, NSAIDs, amitriptyline hydrochloride, baclofen, capsaicin, ketamine, neuropathy, neuropathic pain, pain relief, analgesia, analgesic, penetration enhancers, rate controllers


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